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Proton pencil beam scanning (PBS) treatment planning for head & neck (H&N) cancers involves numerous conflicting objectives, requiring iterative objective parameter adjustments to balance multiple clinical goals. We propose a…

Artificial Intelligence · Computer Science 2025-09-16 Qingqing Wang , Liqiang Xiao , Chang Chang

Pioneering companies such as Waymo have deployed robo-taxi services in several U.S. cities. These robo-taxis are electric vehicles, and their operations require the joint optimization of ride matching, vehicle repositioning, and charging…

Artificial Intelligence · Computer Science 2025-04-29 Jim Dai , Manxi Wu , Zhanhao Zhang

Problem definition: Access to accurate predictions of patients' outcomes can enhance medical staff's decision-making, which ultimately benefits all stakeholders in the hospitals. A large hospital network in the US has been collaborating…

Test-time policy optimization enables large language models (LLMs) to adapt to distribution shifts by leveraging feedback from self-generated rollouts. However, existing methods rely on fixed-budget majority voting to estimate rewards,…

Machine Learning · Computer Science 2025-12-03 Youkang Wang , Jian Wang , Rubing Chen , Tianyi Zeng , Xiao-Yong Wei , Qing Li

Aligning large-scale vision-language models (VLMs) for complex reasoning via reinforcement learning is often hampered by the limitations of existing policy optimization algorithms, such as static training schedules and the rigid, uniform…

Artificial Intelligence · Computer Science 2025-10-02 Yunhao Wang , Ziting Li , Shuai Chen , Tao Liu , Chao Song , Junjie Jiang , Jian Zhu , Peng Gao , Bin Qin

Resource allocation in High Performance Computing (HPC) environments presents a complex and multifaceted challenge for job scheduling algorithms. Beyond the efficient allocation of system resources, schedulers must account for and optimize…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-05-08 Matthew Sgambati , Aleksandar Vakanski , Matthew Anderson

Patients whose transfer to the Intensive Care Unit (ICU) is unplanned are prone to higher mortality rates than those who were admitted directly to the ICU. Recent advances in machine learning to predict patient deterioration have introduced…

Machine Learning · Computer Science 2021-01-26 Julien Grand-Clement , Carri W. Chan , Vineet Goyal , Gabriel Escobar

We study a continuous-time, infinite-horizon dynamic bipartite matching problem. Suppliers arrive according to a Poisson process; while waiting, they may abandon the queue at a uniform rate. Customers on the other hand must be matched upon…

Data Structures and Algorithms · Computer Science 2025-06-03 Alireza AmaniHamedani , Ali Aouad , Amin Saberi

A fundamental challenge in reinforcement learning is to learn policies that generalize beyond the operating domains experienced during training. In this paper, we approach this challenge through the following invariance principle: an agent…

Machine Learning · Computer Science 2020-11-10 Anoopkumar Sonar , Vincent Pacelli , Anirudha Majumdar

We investigate an optimization problem in a queueing system where the service provider selects the optimal service fee p and service capacity \mu to maximize the cumulative expected profit (the service revenue minus the capacity cost and…

Optimization and Control · Mathematics 2025-08-12 Xinyun Chen , Guiyu Hong , Yunan Liu

Diagnostic errors remain a major cause of preventable mortality, particularly in resource limited settings. Medical training simulators, including robopatients, help reduce such errors by replicating patient responses during procedures such…

While large language models (LLMs) have recently made tremendous progress towards solving challenging AI problems, they have done so at increasingly steep computational and API costs. We propose a novel strategy where we combine multiple…

Machine Learning · Computer Science 2026-03-24 Wenwen Si , Sooyong Jang , Insup Lee , Osbert Bastani

Stochastic processing networks (SPNs) have broad applications in healthcare, transportation, and communication networks. The control of SPN is to dynamically assign servers in batches under uncertainty to optimize long-run performance. This…

Systems and Control · Electrical Eng. & Systems 2025-10-09 Jim Dai , Manxi Wu , Zhanhao Zhang

In this paper, a new adaptive multi-batch experience replay scheme is proposed for proximal policy optimization (PPO) for continuous action control. On the contrary to original PPO, the proposed scheme uses the batch samples of past…

Machine Learning · Computer Science 2018-10-03 Seungyul Han , Youngchul Sung

Recent statistical and reinforcement learning methods have significantly advanced patient care strategies. However, these approaches face substantial challenges in high-stakes contexts, including missing data, inherent stochasticity, and…

Machine Learning · Computer Science 2024-04-02 Harsh Parikh , Quinn Lanners , Zade Akras , Sahar F. Zafar , M. Brandon Westover , Cynthia Rudin , Alexander Volfovsky

With the timely formation of personalized intervention plans based on high-dimensional heterogeneous time series information becoming an important challenge in the medical field today, electronic medical records, wearables, and other…

Artificial Intelligence · Computer Science 2025-04-29 Dingxin Lu , Shurui Wu , Xinyi Huang

Patient scheduling is a difficult task involving stochastic factors such as the unknown arrival times of patients. Similarly, the scheduling of radiotherapy for cancer treatments needs to handle patients with different urgency levels when…

Machine Learning · Computer Science 2022-10-25 Tu-San Pham , Antoine Legrain , Patrick De Causmaecker , Louis-Martin Rousseau

Effective information seeking in multi-turn medical dialogues is critical for accurate diagnosis, especially when dealing with incomplete information. Aligning Large Language Models (LLMs) for these interactive scenarios is challenging due…

Machine Learning · Computer Science 2026-03-04 Ruike Cao , Shaojie Bai , Fugen Yao , Liang Dong , Jian Xu , Li Xiao

Proximal Policy Optimization (PPO) is widely used in continuous control due to its robustness and stable training, yet it remains sample-inefficient in tasks with expensive interactions and high-dimensional action spaces. This paper…

Machine Learning · Computer Science 2025-12-16 Tianci Gao , Konstantin A. Neusypin , Dmitry D. Dmitriev , Bo Yang , Shengren Rao

Proximal Policy Optimization (PPO) is among the most widely used algorithms in reinforcement learning, which achieves state-of-the-art performance in many challenging problems. The keys to its success are the reliable policy updates through…

Machine Learning · Computer Science 2021-07-02 Mónika Farsang , Luca Szegletes