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Patient-trial matching requires reasoning over long, heterogeneous electronic health records (EHRs) and complex eligibility criteria, posing significant challenges for scalability, generalization, and computational efficiency. Existing…

Computation and Language · Computer Science 2026-04-27 Xiaodi Li , Yang Xiao , Munhwan Lee , Konstantinos Leventakos , Young J. Juhn , David Jones , Terence T. Sio , Wei Liu , Maria Vassilaki , Nansu Zong

The increasing complexity of clinical decision-making, alongside the rapid expansion of electronic health records (EHR), presents both opportunities and challenges for delivering data-informed care. This paper proposes a clinical decision…

Artificial Intelligence · Computer Science 2025-10-03 Leon Garza , Anantaa Kotal , Michael A. Grasso , Emre Umucu

This paper introduces a system that integrates large language models (LLMs) into the clinical trial retrieval process, enhancing the effectiveness of matching patients with eligible trials while maintaining information privacy and allowing…

Information Retrieval · Computer Science 2024-11-01 Georgios Peikos , Pranav Kasela , Gabriella Pasi

An important issue impacting healthcare is a lack of available experts. Machine learning (ML) models could resolve this by aiding in diagnosing patients. However, creating datasets large enough to train these models is expensive. We…

Computation and Language · Computer Science 2024-05-14 Chancellor R. Woolsey , Prakash Bisht , Joshua Rothman , Gondy Leroy

Despite the recent advancement in Retrieval-Augmented Generation (RAG) systems, most retrieval methodologies are often developed for factual retrieval, which assumes query and positive documents are semantically similar. In this paper, we…

Information Retrieval · Computer Science 2025-04-10 Luo Ji , Feixiang Guo , Teng Chen , Qingqing Gu , Xiaoyu Wang , Ningyuan Xi , Yihong Wang , Peng Yu , Yue Zhao , Hongyang Lei , Zhonglin Jiang , Yong Chen

Training models on synthetic data has emerged as an increasingly important strategy for improving the performance of generative AI. This approach is particularly helpful for large multimodal models (LMMs) due to the relative scarcity of…

Artificial Intelligence · Computer Science 2026-01-13 Gabriela Ben Melech Stan , Estelle Aflalo , Avinash Madasu , Vasudev Lal , Phillip Howard

The rapid growth of medical knowledge and increasing complexity of clinical practice pose challenges. In this context, large language models (LLMs) have demonstrated value; however, inherent limitations remain. Retrieval-augmented…

It is often desirable to distill the capabilities of large language models (LLMs) into smaller student models due to compute and memory constraints. One way to do this for classification tasks is via dataset synthesis, which can be…

Computation and Language · Computer Science 2024-11-14 Abhishek Divekar , Greg Durrett

Test collections play a vital role in evaluation of information retrieval (IR) systems. Obtaining a diverse set of user queries for test collection construction can be challenging, and acquiring relevance judgments, which indicate the…

Information Retrieval · Computer Science 2024-05-14 Hossein A. Rahmani , Nick Craswell , Emine Yilmaz , Bhaskar Mitra , Daniel Campos

Information retrieval systems are crucial for enabling effective access to large document collections. Recent approaches have leveraged Large Language Models (LLMs) to enhance retrieval performance through query augmentation, but often rely…

Information Retrieval · Computer Science 2025-04-15 Pengcheng Jiang , Jiacheng Lin , Lang Cao , Runchu Tian , SeongKu Kang , Zifeng Wang , Jimeng Sun , Jiawei Han

In the field of language modeling, models augmented with retrieval components have emerged as a promising solution to address several challenges faced in the natural language processing (NLP) field, including knowledge grounding,…

Machine Learning · Computer Science 2024-10-22 To Eun Kim , Alireza Salemi , Andrew Drozdov , Fernando Diaz , Hamed Zamani

The collection and curation of high-quality training data is crucial for developing text classification models with superior performance, but it is often associated with significant costs and time investment. Researchers have recently…

Computation and Language · Computer Science 2023-10-16 Zhuoyan Li , Hangxiao Zhu , Zhuoran Lu , Ming Yin

Large language models (LLMs) have shown remarkable effectiveness across various domains, with data augmentation methods utilizing GPT for synthetic data generation becoming prevalent. However, the quality and utility of augmented data…

Computation and Language · Computer Science 2025-01-27 Zeao Tu , Xiangdi Meng , Yu He , Zihan Yao , Tianyu Qi , Jun Liu , Ming Li

Synthetic data generation using large language models (LLMs) demonstrates substantial promise in addressing biomedical data challenges and shows increasing adoption in biomedical research. This study systematically reviews recent advances…

Computation and Language · Computer Science 2026-02-18 Hanshu Rao , Weisi Liu , Haohan Wang , I-Chan Huang , Zhe He , Xiaolei Huang

Large language models (LLMs) have shown impressive promise in code generation, yet their progress remains limited by the shortage of large-scale datasets that are both diverse and well-aligned with human reasoning. Most existing resources…

Machine Learning · Computer Science 2025-10-28 Amal Abed , Ivan Lukic , Jörg K. H. Franke , Frank Hutter

Large language models (LLMs) exhibit remarkable generative capabilities but often suffer from hallucinations. Retrieval-augmented generation (RAG) offers an effective solution by incorporating external knowledge, but existing methods still…

Computation and Language · Computer Science 2024-12-17 Xiaoxi Li , Jiajie Jin , Yujia Zhou , Yongkang Wu , Zhonghua Li , Qi Ye , Zhicheng Dou

Verifiable generation aims to let the large language model (LLM) generate text with supporting documents, which enables the user to flexibly verify the answer and makes the LLM's output more reliable. Retrieval plays a crucial role in…

Computation and Language · Computer Science 2024-03-28 Xiaonan Li , Changtai Zhu , Linyang Li , Zhangyue Yin , Tianxiang Sun , Xipeng Qiu

Patient matching is the process of linking patients to appropriate clinical trials by accurately identifying and matching their medical records with trial eligibility criteria. We propose LLM-Match, a novel framework for patient matching…

Computation and Language · Computer Science 2025-03-26 Xiaodi Li , Shaika Chowdhury , Chung Il Wi , Maria Vassilaki , Xiaoke Liu , Terence T Sio , Owen Garrick , Young J Juhn , James R Cerhan , Cui Tao , Nansu Zong

We investigate the usefulness of generative Large Language Models (LLMs) in generating training data for cross-encoder re-rankers in a novel direction: generating synthetic documents instead of synthetic queries. We introduce a new dataset,…

Information Retrieval · Computer Science 2023-05-04 Arian Askari , Mohammad Aliannejadi , Evangelos Kanoulas , Suzan Verberne

The scarcity of high-quality annotated medical data, particularly in mental health, poses a significant bottleneck for training robust machine learning models. Privacy regulations restrict data sharing, making synthetic data generation a…

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