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Antibodies are versatile proteins that can bind to pathogens and provide effective protection for human body. Recently, deep learning-based computational antibody design has attracted popular attention since it automatically mines the…

Biomolecules · Quantitative Biology 2022-11-18 Kaiyuan Gao , Lijun Wu , Jinhua Zhu , Tianbo Peng , Yingce Xia , Liang He , Shufang Xie , Tao Qin , Haiguang Liu , Kun He , Tie-Yan Liu

Multimodal Large Language Models (MLLMs) have achieved remarkable performance by aligning pretrained visual representations with the linguistic knowledge embedded in Large Language Models (LLMs). However, existing approaches typically rely…

Computer Vision and Pattern Recognition · Computer Science 2026-04-15 Ying Liu , Yudong Han , Kean Shi , Liyuan Pan

Electronic health records (EHR) contain narrative notes that provide extensive details on the medical condition and management of patients. Natural language processing (NLP) of clinical notes can use observed frequencies of clinical terms…

Computation and Language · Computer Science 2023-07-04 Bryan Cai , Sihang Zeng , Yucong Lin , Zheng Yuan , Doudou Zhou , Lu Tian

Neural language modeling (LM) has led to significant improvements in several applications, including Automatic Speech Recognition. However, they typically require large amounts of training data, which is not available for many domains and…

Computation and Language · Computer Science 2019-06-05 Navid Rekabsaz , Nikolaos Pappas , James Henderson , Banriskhem K. Khonglah , Srikanth Madikeri

Large language models (LLMs) have demonstrated remarkable abilities in representation learning for program synthesis and understanding tasks. The quality of the learned representations appears to be dictated by the neural scaling laws as a…

Machine Learning · Computer Science 2023-07-13 Erik Nijkamp , Hiroaki Hayashi , Caiming Xiong , Silvio Savarese , Yingbo Zhou

Large Language Models are increasingly popular in genomics due to their potential to decode complex biological sequences. Hence, researchers require a standardized benchmark to evaluate DNA Language Models (DNA LMs) capabilities. However,…

Genomics · Quantitative Biology 2025-12-12 Davide Greco , Konrad Rawlik

Pretrained language models have achieved state-of-the-art performance when adapted to a downstream NLP task. However, theoretical analysis of these models is scarce and challenging since the pretraining and downstream tasks can be very…

Machine Learning · Computer Science 2022-04-22 Colin Wei , Sang Michael Xie , Tengyu Ma

Recently, integrating visual foundation models into large language models (LLMs) to form video understanding systems has attracted widespread attention. Most of the existing models compress diverse semantic information within the whole…

Computer Vision and Pattern Recognition · Computer Science 2024-09-11 Dingxin Cheng , Mingda Li , Jingyu Liu , Yongxin Guo , Bin Jiang , Qingbin Liu , Xi Chen , Bo Zhao

We introduce HTLM, a hyper-text language model trained on a large-scale web crawl. Modeling hyper-text has a number of advantages: (1) it is easily gathered at scale, (2) it provides rich document-level and end-task-adjacent supervision…

Computation and Language · Computer Science 2021-07-16 Armen Aghajanyan , Dmytro Okhonko , Mike Lewis , Mandar Joshi , Hu Xu , Gargi Ghosh , Luke Zettlemoyer

Protein representation learning is critical for numerous biological tasks. Recently, large transformer-based protein language models (pLMs) pretrained on large scale protein sequences have demonstrated significant success in sequence-based…

Machine Learning · Computer Science 2025-08-12 Xuefeng Liu , Songhao Jiang , Chih-chan Tien , Jinbo Xu , Rick Stevens

Conventional mechanical design follows an iterative process in which initial concepts are refined through cycles of expert assessment and resource-intensive Finite Element Method (FEM) analysis to meet performance goals. While machine…

Machine Learning · Computer Science 2025-05-02 Yayati Jadhav , Amir Barati Farimani

Machine Learning (ML) will play significant role in success of the upcoming High-Luminosity LHC (HL-LHC) program at CERN. The unprecedented amount of data at the Exa-Byte scale to be collected by the CERN experiments in next decade will…

High Energy Physics - Experiment · Physics 2018-11-15 Valentin Kuznetsov

The field of computer vision has experienced significant advancements through scalable vision encoders and multimodal pre-training frameworks. However, existing approaches often treat vision encoders and large language models (LLMs) as…

Computer Vision and Pattern Recognition · Computer Science 2026-04-02 Eugene Lee , Ting-Yu Chang , Jui-Huang Tsai , Jiajie Diao , Chen-Yi Lee

While the role of humans is increasingly recognized in machine learning community, representation of and interaction with models in current human-in-the-loop machine learning (HITL-ML) approaches are too low-level and far-removed from…

Computation and Language · Computer Science 2021-09-17 Yiwei Yang , Eser Kandogan , Yunyao Li , Walter S. Lasecki , Prithviraj Sen

Transformer-based large language models (LLM) have been widely used in language processing applications. However, due to the memory constraints of the devices, most of them restrict the context window. Even though recurrent models in…

Computation and Language · Computer Science 2025-02-07 Zifan He , Yingqi Cao , Zongyue Qin , Neha Prakriya , Yizhou Sun , Jason Cong

Handwritten Text Recognition (HTR) for Arabic-script languages benefits from cross-language joint training under low-resource conditions, particularly when using CRNN-based models that combine convolutional encoders with sequence modeling.…

Computer Vision and Pattern Recognition · Computer Science 2026-05-08 Sana Al-azzawi , Chang Liu , Nudrat Habib , Elisa Barney , Marcus Liwicki

Accurate representation of building semantics, encompassing both generic object types and specific subtypes, is essential for effective AI model training in the architecture, engineering, construction, and operation (AECO) industry.…

Artificial Intelligence · Computer Science 2026-02-18 Suhyung Jang , Ghang Lee , Jaekun Lee , Hyunjun Lee

When adapting an encoder to a new domain, the standard approach is to continue training with Masked Language Modeling (MLM). We show that temporarily switching to Causal Language Modeling (CLM) followed by a short MLM decay improves…

Computation and Language · Computer Science 2026-05-13 Rian Touchent , Eric de la Clergerie

Many pre-trained language models (PLMs) exhibit suboptimal performance on mid- and low-resource languages, largely due to limited exposure to these languages during pre-training. A common strategy to address this is to introduce new tokens…

Computation and Language · Computer Science 2025-07-15 Enes Özeren , Yihong Liu , Hinrich Schütze

Large language models (LLMs) have shown great success in various Natural Language Processing (NLP) tasks, whist they still need updates after deployment to fix errors or keep pace with the changing knowledge in the world. Researchers…

Computation and Language · Computer Science 2023-12-20 Lang Yu , Qin Chen , Jie Zhou , Liang He