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Quantitative susceptibility mapping (QSM) is a useful magnetic resonance imaging (MRI) technique which provides spatial distribution of magnetic susceptibility values of tissues. QSMs can be obtained by deconvolving the dipole kernel from…

Computer Vision and Pattern Recognition · Computer Science 2020-12-08 Gyutaek Oh , Hyokyoung Bae , Hyun-Seo Ahn , Sung-Hong Park , Jong Chul Ye

Deep neural networks excel in radiological image classification but frequently suffer from poor interpretability, limiting clinical acceptance. We present MedicalPatchNet, an inherently self-explainable architecture for chest X-ray…

Computer Vision and Pattern Recognition · Computer Science 2026-02-26 Patrick Wienholt , Christiane Kuhl , Jakob Nikolas Kather , Sven Nebelung , Daniel Truhn

Medical brain image analysis is a necessary step in Computer Assisted /Aided Diagnosis (CAD) systems. Advancements in both hardware and software in the past few years have led to improved segmentation and classification of various diseases.…

Image and Video Processing · Electrical Eng. & Systems 2021-01-15 Darwin Castillo , Vasudevan Lakshminarayanan , Maria J. Rodriguez-Alvarez

Magnetic resonance imaging (MRI) is widely used for screening, diagnosis, image-guided therapy, and scientific research. A significant advantage of MRI over other imaging modalities such as computed tomography (CT) and nuclear imaging is…

Image and Video Processing · Electrical Eng. & Systems 2020-02-20 Qing Lyu , Hongming Shan , Ge Wang

Neuroanatomical segmentation in magnetic resonance imaging (MRI) of the brain is a prerequisite for volume, thickness and shape measurements. This work introduces a new highly accurate and versatile method based on 3D convolutional neural…

Quantitative Methods · Quantitative Biology 2019-02-07 Philip Novosad , Vladimir Fonov , D. Louis Collins

This work introduces a compartment-based model for apparent soma and neurite density imaging (SANDI) using non-invasive diffusion-weighted MRI (DW-MRI). The existing conjecture in brain microstructure imaging trough DW-MRI presents water…

Segmentation and quantification of white matter hyperintensities (WMHs) are of great importance in studying and understanding various neurological and geriatric disorders. Although automatic methods have been proposed for WMH segmentation…

Computer Vision and Pattern Recognition · Computer Science 2018-03-20 Dakai Jin , Ziyue Xu , Adam P. Harrison , Daniel J. Mollura

Purpose: This study aims to develop a high-resolution whole-brain multi-parametric quantitative MRI approach for simultaneous mapping of myelin-water fraction (MWF), T1, T2, and proton-density (PD), all within a clinically feasible scan…

Sodium magnetic resonance imaging (MRI) is sensitive and specific to ionic balance of cells owing to 10 fold difference in sodium concentration across membrane actively maintained by sodium potassium (Na+ K+) pump. Disruption of the pump…

Medical Physics · Physics 2025-08-21 Yongxian Qian , Ying-Chia Lin , Xingye Chen , Yulin Ge , Yvonne W. Lui , Fernando E. Boada

Mild cognitive impairment (MCI) is characterized by subtle changes in cognitive functions, often associated with disruptions in brain connectivity. The present study introduces a novel fine-grained analysis to examine topological…

Computer Vision and Pattern Recognition · Computer Science 2024-08-29 Ninad Aithal , Debanjali Bhattacharya , Neelam Sinha , Thomas Gregor Issac

Deep learning networks have shown promising results in fast magnetic resonance imaging (MRI) reconstruction. In our work, we develop deep networks to further improve the quantitative and the perceptual quality of reconstruction. To begin…

Brain lesion volume measured on T2 weighted MRI images is a clinically important disease marker in multiple sclerosis (MS). Manual delineation of MS lesions is a time-consuming and highly operator-dependent task, which is influenced by…

Image and Video Processing · Electrical Eng. & Systems 2023-11-28 Hang Zhang , Jinwei Zhang , Qihao Zhang , Jeremy Kim , Shun Zhang , Susan A. Gauthier , Pascal Spincemaille , Thanh D. Nguyen , Mert R. Sabuncu , Yi Wang

Pathologically altered iron levels, detected using iron-sensitive MRI techniques such as quantitative susceptibility mapping (QSM), are observed in neurological disorders such as multiple sclerosis (MS) and may play a crucial role in…

A learning-based posterior distribution estimation method, Probabilistic Dipole Inversion (PDI), is proposed to solve the quantitative susceptibility mapping (QSM) inverse problem in MRI with uncertainty estimation. In PDI, a deep…

Image and Video Processing · Electrical Eng. & Systems 2021-03-16 Jinwei Zhang , Hang Zhang , Mert Sabuncu , Pascal Spincemaille , Thanh Nguyen , Yi Wang

A learning-based posterior distribution estimation method, Probabilistic Dipole Inversion (PDI), is proposed to solve quantitative susceptibility mapping (QSM) inverse problem in MRI with uncertainty estimation. A deep convolutional neural…

Image and Video Processing · Electrical Eng. & Systems 2020-04-28 Jinwei Zhang , Hang Zhang , Mert Sabuncu , Pascal Spincemaille , Thanh Nguyen , Yi Wang

Automated brain structure segmentation is important to many clinical quantitative analysis and diagnoses. In this work, we introduce MixNet, a 2D semantic-wise deep convolutional neural network to segment brain structure in multi-modality…

Image and Video Processing · Electrical Eng. & Systems 2020-04-22 Long Chen , Dorit Merhof

The Ki-67 proliferation index is an essential biomarker that helps pathologists to diagnose and select appropriate treatments. However, automatic evaluation of Ki-67 is difficult due to nuclei overlapping and complex variations in their…

Image and Video Processing · Electrical Eng. & Systems 2022-03-16 Khaled Benaggoune , Zeina Al Masry , Jian Ma , Christine Devalland , L. H Mouss , Noureddine Zerhouni

Quantitative MRI (qMRI) methods allow reducing the subjectivity of clinical MRI by providing numerical values on which diagnostic assessment or predictions of tissue properties can be based. However, qMRI measurements typically take more…

Medical Physics · Physics 2022-02-15 Matti Hanhela , Antti Paajanen , Mikko J. Nissi , Ville Kolehmainen

Quantitative magnetic resonance imaging (qMRI) allows images to be compared across sites and time points, which is particularly important for assessing long-term conditions or for longitudinal studies. The multiparametric mapping (MPM)…

Signal Processing · Electrical Eng. & Systems 2024-10-24 Klara Baś , Christian Lambert , John Ashburner

White matter hyperintensity (WMH) is commonly found in elder individuals and appears to be associated with brain diseases. U-net is a convolutional network that has been widely used for biomedical image segmentation. Recently, U-net has…

Computer Vision and Pattern Recognition · Computer Science 2018-07-30 Yue Zhang , Wanli Chen , Yifan Chen , Xiaoying Tang