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The discovery of causal relationships is a fundamental problem in science and medicine. In recent years, many elegant approaches to discovering causal relationships between two variables from observational data have been proposed. However,…

Machine Learning · Statistics 2021-06-22 Ciarán M. Lee , Christopher Hart , Jonathan G. Richens , Saurabh Johri

Discovering causal structures with latent variables from observational data is a fundamental challenge in causal discovery. Existing methods often rely on constraint-based, iterative discrete searches, limiting their scalability to large…

Machine Learning · Computer Science 2024-12-02 Parjanya Prashant , Ignavier Ng , Kun Zhang , Biwei Huang

Causal graph discovery is a significant problem with applications across various disciplines. However, with observational data alone, the underlying causal graph can only be recovered up to its Markov equivalence class, and further…

Machine Learning · Computer Science 2024-02-14 Davin Choo , Kirankumar Shiragur , Caroline Uhler

Due to a wide spectrum of applications in the real world, such as security, financial surveillance, and health risk, various deep anomaly detection models have been proposed and achieved state-of-the-art performance. However, besides being…

Machine Learning · Computer Science 2023-09-08 Xiao Han , Lu Zhang , Yongkai Wu , Shuhan Yuan

Root Cause Analysis (RCA) aims at identifying the underlying causes of system faults by uncovering and analyzing the causal structure from complex systems. It has been widely used in many application domains. Reliable diagnostic conclusions…

Artificial Intelligence · Computer Science 2024-07-15 Chang Gong , Di Yao , Jin Wang , Wenbin Li , Lanting Fang , Yongtao Xie , Kaiyu Feng , Peng Han , Jingping Bi

Root cause analysis of anomalies aims to identify how and why a sample deviates from the normal process. Existing methods primarily focus on telling which features are responsible, ignoring that anomalies can arise through two fundamentally…

Machine Learning · Computer Science 2026-05-12 Hendrik Suhr , David Kaltenpoth , Jilles Vreeken

Inferring causal structures from experimentation is a central task in many domains. For example, in biology, recent advances allow us to obtain single-cell expression data under multiple interventions such as drugs or gene knockouts.…

Machine Learning · Computer Science 2023-02-24 Alexander Hägele , Jonas Rothfuss , Lars Lorch , Vignesh Ram Somnath , Bernhard Schölkopf , Andreas Krause

Causal disentanglement seeks a representation of data involving latent variables that relate to one another via a causal model. A representation is identifiable if both the latent model and the transformation from latent to observed…

Machine Learning · Statistics 2023-06-13 Chandler Squires , Anna Seigal , Salil Bhate , Caroline Uhler

Causal discovery from observational and interventional data is challenging due to limited data and non-identifiability: factors that introduce uncertainty in estimating the underlying structural causal model (SCM). Selecting experiments…

Machine Learning · Computer Science 2022-10-24 Panagiotis Tigas , Yashas Annadani , Andrew Jesson , Bernhard Schölkopf , Yarin Gal , Stefan Bauer

Many natural phenomena are intrinsically causal. The discovery of the cause-effect relationships implicit in these processes can help us to understand and describe them more effectively, which boils down to causal discovery about the data…

Quantitative Methods · Quantitative Biology 2024-01-09 Jean Pierre Gomez

Causal disentanglement aims to uncover a representation of data using latent variables that are interrelated through a causal model. Such a representation is identifiable if the latent model that explains the data is unique. In this paper,…

We focus on causal discovery in the presence of measurement error in linear systems where the mixing matrix, i.e., the matrix indicating the independent exogenous noise terms pertaining to the observed variables, is identified up to…

Machine Learning · Computer Science 2022-11-09 Yuqin Yang , AmirEmad Ghassami , Mohamed Nafea , Negar Kiyavash , Kun Zhang , Ilya Shpitser

Causal discovery in multi-omic datasets is crucial for understanding the bigger picture of gene regulatory mechanisms, but remains challenging due to high dimensionality, differentiation of direct from indirect relationships, and hidden…

Genomics · Quantitative Biology 2025-05-23 Stephen Asiedu , David Watson

Linear causal models are important tools for modeling causal dependencies and yet in practice, only a subset of the variables can be observed. In this paper, we examine the parameter identifiability of these models by investigating whether…

Machine Learning · Computer Science 2025-02-11 Xinshuai Dong , Ignavier Ng , Biwei Huang , Yuewen Sun , Songyao Jin , Roberto Legaspi , Peter Spirtes , Kun Zhang

In the algorithm Intersort, Chevalley et al. (2024) proposed a score-based method to discover the causal order of variables in a Directed Acyclic Graph (DAG) model, leveraging interventional data to outperform existing methods. However, as…

Machine Learning · Computer Science 2024-10-14 Mathieu Chevalley , Arash Mehrjou , Patrick Schwab

The ability to answer causal questions is crucial in many domains, as causal inference allows one to understand the impact of interventions. In many applications, only a single intervention is possible at a given time. However, in some…

Machine Learning · Statistics 2022-10-12 Olivier Jeunen , Ciarán M. Gilligan-Lee , Rishabh Mehrotra , Mounia Lalmas

In drug discovery, mapping interactions between genes within cellular systems is a crucial early step. Such maps are not only foundational for understanding the molecular mechanisms underlying disease biology but also pivotal for…

The study of cells and their responses to genetic or chemical perturbations promises to accelerate the discovery of therapeutic targets. However, designing adequate and insightful models for such data is difficult because the response of a…

Machine Learning · Computer Science 2024-12-04 Haiyi Mao , Romain Lopez , Kai Liu , Jan-Christian Hütter , David Richmond , Panayiotis V. Benos , Lin Qiu

Causal discovery aims to infer causal relationships among variables from observational data, typically represented by a directed acyclic graph (DAG). Most existing methods assume independent and identically distributed observations, an…

Methodology · Statistics 2026-03-27 Alex Chen , Qing Zhou

Advances in single-cell omics allow for unprecedented insights into the transcription profiles of individual cells. When combined with large-scale perturbation screens, through which specific biological mechanisms can be targeted, these…

Machine Learning · Computer Science 2023-10-24 Alejandro Tejada-Lapuerta , Paul Bertin , Stefan Bauer , Hananeh Aliee , Yoshua Bengio , Fabian J. Theis