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Local hemodynamic forces play an important role in determining the functional significance of coronary arterial stenosis and understanding the mechanism of coronary disease progression. Computational fluid dynamics (CFD) have been widely…

Computer Vision and Pattern Recognition · Computer Science 2023-05-31 Ziyu Ni , Linda Wei , Lijian Xu , Simon Yu , Qing Xia , Hongsheng Li , Shaoting Zhang

Hemodynamic quantities are valuable biomedical risk factors for cardiovascular pathology such as atherosclerosis. Non-invasive, in-vivo measurement of these quantities can only be performed using a select number of modalities that are not…

Quantitative Methods · Quantitative Biology 2026-02-23 Julian Suk , Dieuwertje Alblas , Barbara A. Hutten , Albert Wiegman , Christoph Brune , Pim van Ooij , Jelmer M. Wolterink

Computational fluid dynamics (CFD) based simulation of coronary blood flow provides valuable hemodynamic markers, such as pressure gradients, for diagnosing coronary artery disease (CAD). However, CFD is computationally expensive,…

Computer Vision and Pattern Recognition · Computer Science 2025-12-12 Rene Lisasi , Michele Esposito , Chen Zhao

Patient-specific hemodynamics assessment could support diagnosis and treatment of neurovascular diseases. Currently, conventional medical imaging modalities are not able to accurately acquire high-resolution hemodynamic information that…

Hemodynamic parameters such as pressure and wall shear stress play an important role in diagnosis, prognosis, and treatment planning in cardiovascular diseases. These parameters can be accurately computed using computational fluid dynamics…

Computer Vision and Pattern Recognition · Computer Science 2025-08-28 Patryk Rygiel , Julian Suk , Kak Khee Yeung , Christoph Brune , Jelmer M. Wolterink

Image-based modeling is essential for understanding cardiovascular hemodynamics and advancing the diagnosis and treatment of cardiovascular diseases. Constructing patient-specific vascular models remains labor-intensive, error-prone, and…

Computer Vision and Pattern Recognition · Computer Science 2025-03-18 Pan Du , Delin An , Chaoli Wang , Jian-Xun Wang

Intracardiac flow patterns are shaped by the coupled motion of the cardiac chambers and heart valves and provide important information about cardiac function. However, clinical flow imaging remains limited by exam times, noise, resolution,…

Image and Video Processing · Electrical Eng. & Systems 2026-05-12 Fanwei Kong , Aaron Brown , Michael Loecher , Perry S. Choi , Lei Shi , Michael Ma , Daniel B. Ennis , Alison Marsden

Computational fluid dynamics (CFD) is a valuable tool for personalised, non-invasive evaluation of hemodynamics in arteries, but its complexity and time-consuming nature prohibit large-scale use in practice. Recently, the use of deep…

Machine Learning · Computer Science 2022-01-21 Julian Suk , Pim de Haan , Phillip Lippe , Christoph Brune , Jelmer M. Wolterink

Fractional flow reserve (FFR) is the gold standard for diagnosing coronary artery disease (CAD). FFRCT uses computational fluid dynamics (CFD) to evaluate FFR non-invasively by simulating coronary flow in geometries reconstructed from…

Predictive modeling of blood flow and pressure have numerous applications ranging from non-invasive assessment of functional significance of disease to planning invasive procedures. While several such predictive modeling techniques have…

Prediction of the blood flow characteristics is of utmost importance for understanding the behavior of the blood arterial network, especially in the presence of vascular diseases such as stenosis. Computational fluid dynamics (CFD) has…

Machine Learning · Computer Science 2021-11-11 Mohammad Farajtabar , Mohit Biglarian , Morteza Miansari

Advances in computational science offer a principled pipeline for predictive modeling of cardiovascular flows and aspire to provide a valuable tool for monitoring, diagnostics and surgical planning. Such models can be nowadays deployed on…

Machine Learning · Computer Science 2019-09-19 Georgios Kissas , Yibo Yang , Eileen Hwuang , Walter R. Witschey , John A. Detre , Paris Perdikaris

Computational fluid dynamics (CFD) can be used to simulate vascular haemodynamics and analyse potential treatment options. CFD has shown to be beneficial in improving patient outcomes. However, the implementation of CFD for routine clinical…

Computational fluid dynamics (CFD) is a valuable asset for patient-specific cardiovascular-disease diagnosis and prognosis, but its high computational demands hamper its adoption in practice. Machine-learning methods that estimate blood…

Machine Learning · Computer Science 2024-06-18 Julian Suk , Pim de Haan , Phillip Lippe , Christoph Brune , Jelmer M. Wolterink

We propose a fully automated algorithm based on a deep learning framework enabling screening of a coronary computed tomography angiography (CCTA) examination for confident detection of the presence or absence of coronary artery…

Image and Video Processing · Electrical Eng. & Systems 2020-06-09 Sema Candemir , Richard D. White , Mutlu Demirer , Vikash Gupta , Matthew T. Bigelow , Luciano M. Prevedello , Barbaros S. Erdal

Cardiovascular modeling has rapidly advanced over the past few decades due to the rising needs for health tracking and early detection of cardiovascular diseases. While 1-D arterial models offer an attractive compromise between…

Changes in cardiovascular hemodynamics are closely related to the development of aortic regurgitation, a type of valvular heart disease. Metrics derived from blood flows are used to indicate aortic regurgitation onset and evaluate its…

Computer Vision and Pattern Recognition · Computer Science 2022-04-07 Derek Long , Cameron McMurdo , Edward Ferdian , Charlene A. Mauger , David Marlevi , Alistair A. Young , Martyn P. Nash

Coronary artery disease, caused by the narrowing of coronary vessels due to atherosclerosis, is the leading cause of death worldwide. The diagnostic gold standard, fractional flow reserve (FFR), measures the trans-stenotic pressure ratio…

Image and Video Processing · Electrical Eng. & Systems 2025-01-24 Guido Nannini , Julian Suk , Patryk Rygiel , Simone Saitta , Luca Mariani , Riccardo Maragna , Andrea Baggiano , Gianluca Pontone , Jelmer M. Wolterink , Alberto Redaelli

Coronary artery disease (CAD) is one of the most common causes of death in the European Union and the USA. The crucial biomarker in its diagnosis is called Fractional Flow Reserve (FFR) and its in-vivo measurement is obtained via an…

Image and Video Processing · Electrical Eng. & Systems 2024-05-22 Patryk Rygiel

Determining brain hemodynamics plays a critical role in the diagnosis and treatment of various cerebrovascular diseases. In this work, we put forth a physics-informed deep learning framework that augments sparse clinical measurements with…

Medical Physics · Physics 2021-08-27 Mohammad Sarabian , Hessam Babaee , Kaveh Laksari
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