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Imputation using external reference panels is a widely used approach for increasing power in GWAS and meta-analysis. Existing HMM-based imputation approaches require individual-level genotypes. Here, we develop a new method for Gaussian…

Data imputation is an effective way to handle missing data, which is common in practical applications. In this study, we propose and test a novel data imputation process that achieve two important goals: (1) preserve the row-wise…

Machine Learning · Computer Science 2023-09-13 Katrina Chen , Xiuqin Liang , Zheng Ma , Zhibin Zhang

Missing data is a crucial issue when applying machine learning algorithms to real-world datasets. Starting from the simple assumption that two batches extracted randomly from the same dataset should share the same distribution, we leverage…

Machine Learning · Statistics 2020-07-02 Boris Muzellec , Julie Josse , Claire Boyer , Marco Cuturi

Genomics data such as RNA gene expression, methylation and micro RNA expression are valuable sources of information for various clinical predictive tasks. For example, predicting survival outcomes, cancer histology type and other patients'…

Genomics · Quantitative Biology 2022-05-26 Sophie Peacock , Etai Jacob , Nikolay Burlutskiy

Imputation methods play a critical role in enhancing the quality of practical time-series data, which often suffer from pervasive missing values. Recently, diffusion-based generative imputation methods have demonstrated remarkable success…

Machine Learning · Computer Science 2025-10-03 Zeqi Ye , Minshuo Chen

In this study, we introduce a sophisticated generative conditional strategy designed to impute missing values within datasets, an area of considerable importance in statistical analysis. Specifically, we initially elucidate the theoretical…

Machine Learning · Statistics 2026-01-05 George Sun , Yi-Hui Zhou

When working with tabular data, missingness is always one of the most painful problems. Throughout many years, researchers have continuously explored better and better ways to impute missing data. Recently, with the rapid development…

Machine Learning · Computer Science 2025-09-09 Tin Luu , Binh Nguyen , Man Ngo

Although data may be abundant, complete data is less so, due to missing columns or rows. This missingness undermines the performance of downstream data products that either omit incomplete cases or create derived completed data for…

Machine Learning · Computer Science 2020-06-26 Haw-minn Lu , Giancarlo Perrone , José Unpingco

We introduce the Markov missing graph (MMG), a novel framework that imputes missing data based on undirected graphs. MMG leverages conditional independence relationships to locally decompose the imputation model. To establish the…

Methodology · Statistics 2025-09-04 Yanjiao Yang , Yen-Chi Chen

A wide range of systems exhibit high dimensional incomplete data. Accurate estimation of the missing data is often desired, and is crucial for many downstream analyses. Many state-of-the-art recovery methods involve supervised learning…

Computer Vision and Pattern Recognition · Computer Science 2019-03-15 Adrian V. Dalca , John Guttag , Mert R. Sabuncu

Several statistical models are given in the form of unnormalized densities, and calculation of the normalization constant is intractable. We propose estimation methods for such unnormalized models with missing data. The key concept is to…

Machine Learning · Statistics 2020-06-11 Masatoshi Uehara , Takeru Matsuda , Jae Kwang Kim

Factor models are widely used to reduce dimensionality in modeling high-dimensional data. However, there remains a need for models that can be reliably fit in modest sample sizes and are identifiable, interpretable, and flexible. To address…

Methodology · Statistics 2025-06-19 Maoran Xu , Steven Winter , Amy H. Herring , David B. Dunson

Real-world clinical time series data sets exhibit a high prevalence of missing values. Hence, there is an increasing interest in missing data imputation. Traditional statistical approaches impose constraints on the data-generating process…

Machine Learning · Computer Science 2020-01-13 Yang Guo , Zhengyuan Liu , Pavitra Krishnswamy , Savitha Ramasamy

Mixtures of factor analysers (MFA) models represent a popular tool for finding structure in data, particularly high-dimensional data. While in most applications the number of clusters, and especially the number of latent factors within…

Methodology · Statistics 2023-07-17 Margarita Grushanina , Sylvia Frühwirth-Schnatter

Stochastic volatility models that treat the variance of a time series as a stochastic process have proven to be important tools for analyzing dynamic variability. Current methods for fitting and conducting inference on stochastic volatility…

Methodology · Statistics 2025-01-28 Gehui Zhang , Gong Tang , Lori Scott , Robert T Krafty

Factor analysis is a critical component of high dimensional biological data analysis. However, modern biological data contain two key features that irrevocably corrupt existing methods. First, these data, which include longitudinal,…

Methodology · Statistics 2020-09-24 Chris McKennan

Multivariate time series with missing values are common in areas such as healthcare and finance, and have grown in number and complexity over the years. This raises the question whether deep learning methodologies can outperform classical…

Machine Learning · Statistics 2020-02-21 Vincent Fortuin , Dmitry Baranchuk , Gunnar Rätsch , Stephan Mandt

Missing data is a widespread problem in many domains, creating challenges in data analysis and decision making. Traditional techniques for dealing with missing data, such as excluding incomplete records or imputing simple estimates (e.g.,…

Databases · Computer Science 2024-01-09 Massimo Perini , Milos Nikolic

Accurate quantification of intracellular metabolic fluxes is central to systems biology and biotechnology. Flux estimation relies on biochemical network models, with $^{13}$C metabolic flux analysis (MFA) being the state-of-the-art…

Quantitative Methods · Quantitative Biology 2026-05-26 Johann F. Jadebeck , Anton Stratmann , Martin Beyß , Katharina Nöh

This paper proposes a general multiple imputation approach for analyzing large-scale data with missing values. An imputation model is derived from a joint distribution induced by a latent variable model, which can flexibly capture…

Methodology · Statistics 2025-09-26 Siliang Zhang , Yunxiao Chen , Jouni Kuha