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Quantitative studies of cell metabolism are often based on large chemical reaction network models. A steady state approach is suited to analyze phenomena on the timescale of cell growth and circumvents the problem of incomplete experimental…

Molecular Networks · Quantitative Biology 2019-02-20 A. De Martino , D. De Martino , E. Marinari

The problem of missing values in multivariable time series is a key challenge in many applications such as clinical data mining. Although many imputation methods show their effectiveness in many applications, few of them are designed to…

Machine Learning · Computer Science 2020-03-04 Ye Xue , Diego Klabjan , Yuan Luo

Multi-view unsupervised feature selection (MUFS), which selects informative features from multi-view unlabeled data, has attracted increasing research interest in recent years. Although great efforts have been devoted to MUFS, several…

Machine Learning · Computer Science 2025-11-12 Minghui Lu , Yanyong Huang , Minbo Ma , Jinyuan Chang , Dongjie Wang , Xiuwen Yi , Tianrui Li

Imputation methods for dealing with incomplete data typically assume that the missingness mechanism is at random (MAR). These methods can also be applied to missing not at random (MNAR) situations, where the user specifies some adjustment…

Methodology · Statistics 2024-04-24 Shahab Jolani , Stef van Buuren

The reliability of the results of network meta-analysis (NMA) lies in the plausibility of key assumption of transitivity. This assumption implies that the effect modifiers' distribution is similar across treatment comparisons. Transitivity…

Generalized latent factor analysis not only provides a useful latent embedding approach in statistics and machine learning, but also serves as a widely used tool across various scientific fields, such as psychometrics, econometrics, and…

Methodology · Statistics 2025-08-11 Chengyu Cui , Gongjun Xu

Matrix factorization methods - including Factor analysis (FA), and Principal Components Analysis (PCA) - are widely used for inferring and summarizing structure in multivariate data. Many matrix factorization methods exist, corresponding to…

Methodology · Statistics 2021-05-04 Wei Wang , Matthew Stephens

Factor Analysis based on multivariate $t$ distribution ($t$fa) is a useful robust tool for extracting common factors on heavy-tailed or contaminated data. However, $t$fa is only applicable to vector data. When $t$fa is applied to matrix…

Machine Learning · Statistics 2024-01-05 Xuan Ma , Jianhua Zhao , Changchun Shang , Fen Jiang , Philip L. H. Yu

Balanced truncation is a well-established model order reduction method which has been applied to a variety of problems. Recently, a connection between linear Gaussian Bayesian inference problems and the system-theoretic concept of balanced…

Numerical Analysis · Mathematics 2024-01-04 Josie König , Melina A. Freitag

Gaussian processes (GPs) are a powerful tool for probabilistic inference over functions. They have been applied to both regression and non-linear dimensionality reduction, and offer desirable properties such as uncertainty estimates,…

Machine Learning · Statistics 2014-10-01 Yarin Gal , Mark van der Wilk , Carl E. Rasmussen

Missing value imputation is a fundamental challenge in machine intelligence, heavily dependent on data completeness. Current imputation methods often handle numerical and categorical attributes independently, overlooking critical…

Machine Learning · Computer Science 2026-01-09 Xiaopeng Luo , Zexi Tan , Zhuowei Wang

A simultaneous enhancement of accuracy and diversity of predictions remains a challenge in ambiguous medical image segmentation (AMIS) due to the inherent trade-offs. While truncated diffusion probabilistic models (TDPMs) hold strong…

Computer Vision and Pattern Recognition · Computer Science 2025-12-01 Fanding Li , Xiangyu Li , Xianghe Su , Xingyu Qiu , Suyu Dong , Wei Wang , Kuanquan Wang , Gongning Luo , Shuo Li

We investigate methods for penalized regression in the presence of missing observations. This paper introduces a method for estimating the parameters which compensates for the missing observations. We first, derive an unbiased estimator of…

Applications · Statistics 2013-10-09 Yunjin Choi , Robert Tibshirani

The analysis of clinical questionnaire data comes with many inherent challenges. These challenges include the handling of data with missing fields, as well as the overall interpretation of a dataset with many fields of different scales and…

Machine Learning · Computer Science 2021-08-04 Connor J. McLaughlin , Efi G. Kokkotou , Jean A. King , Lisa A. Conboy , Ali Yousefi

A common problem faced by statistical institutes is that data may be missing from collected data sets. The typical way to overcome this problem is to impute the missing data. The problem of imputing missing data is complicated by the fact…

Applications · Statistics 2014-01-09 Jeroen Pannekoek , Natalie Shlomo , Ton De Waal

High-dimensional and sparse (HiDS) matrices are omnipresent in a variety of big data-related applications. Latent factor analysis (LFA) is a typical representation learning method that extracts useful yet latent knowledge from HiDS matrices…

Machine Learning · Computer Science 2022-04-19 Di Wu , Peng Zhang , Yi He , Xin Luo

This paper tackles the problem of missing data imputation for noisy and non-Gaussian data. A classical imputation method, the Expectation Maximization (EM) algorithm for Gaussian mixture models, has shown interesting properties when…

Machine Learning · Statistics 2023-05-23 Florian Mouret , Alexandre Hippert-Ferrer , Frédéric Pascal , Jean-Yves Tourneret

It is more and more common to explore the genome at diverse levels and not only at a single omic level. Through integrative statistical methods, omics data have the power to reveal new biological processes, potential biomarkers, and…

Methodology · Statistics 2021-03-05 Morgane Pierre-Jean , Florence Mauger , Jean-François Deleuze , Edith Le Floch

We propose a novel approach to estimating the precision matrix of multivariate Gaussian data that relies on decomposing them into a low-rank and a diagonal component. Such decompositions are very popular for modeling large covariance…

Methodology · Statistics 2022-08-18 Noirrit Kiran Chandra , Peter Mueller , Abhra Sarkar

Motivation: Modelling methods that find structure in data are necessary with the current large volumes of genomic data, and there have been various efforts to find subsets of genes exhibiting consistent patterns over subsets of treatments.…

Machine Learning · Computer Science 2016-09-15 Kerstin Bunte , Eemeli Leppäaho , Inka Saarinen , Samuel Kaski
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