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Proteins are fundamental to biology, executing diverse functions through complex physicochemical interactions, and they hold transformative potential across medicine, materials science, and environmental applications. Protein Language…

Biomolecules · Quantitative Biology 2025-06-11 Logan Hallee , Nikolaos Rafailidis , David B. Bichara , Jason P. Gleghorn

Diffusion models have emerged as a powerful class of generative models for molecular design, capable of capturing complex structural distributions and achieving high fidelity in 3D molecule generation. However, their widespread use remains…

Machine Learning · Computer Science 2026-01-15 Adrita Das , Peiran Jiang , Dantong Zhu , Barnabas Poczos , Jose Lugo-Martinez

Denoising diffusion probabilistic models (DDPMs) have recently achieved leading performances in many generative tasks. However, the inherited iterative sampling process costs hinder their applications to text-to-speech deployment. Through…

Audio and Speech Processing · Electrical Eng. & Systems 2022-07-14 Rongjie Huang , Zhou Zhao , Huadai Liu , Jinglin Liu , Chenye Cui , Yi Ren

Discrete diffusion models have demonstrated great promise in modeling various sequence data, ranging from human language to biological sequences. Inspired by the success of RL in language models, there is growing interest in further…

Machine Learning · Computer Science 2026-02-03 Jiaqi Han , Austin Wang , Minkai Xu , Wenda Chu , Meihua Dang , Haotian Ye , Huayu Chen , Yisong Yue , Stefano Ermon

Denoising diffusion probabilistic models (DDPM) are powerful hierarchical latent variable models with remarkable sample generation quality and training stability. These properties can be attributed to parameter sharing in the generative…

Computer Vision and Pattern Recognition · Computer Science 2022-06-01 Giorgio Giannone , Didrik Nielsen , Ole Winther

Diffusion models have emerged as a popular family of deep generative models (DGMs). In the literature, it has been claimed that one class of diffusion models -- denoising diffusion probabilistic models (DDPMs) -- demonstrate superior image…

Image and Video Processing · Electrical Eng. & Systems 2023-09-20 Rucha Deshpande , Muzaffer Özbey , Hua Li , Mark A. Anastasio , Frank J. Brooks

Medical image segmentation is a challenging task, made more difficult by many datasets' limited size and annotations. Denoising diffusion probabilistic models (DDPM) have recently shown promise in modelling the distribution of natural…

Computer Vision and Pattern Recognition · Computer Science 2023-11-14 Margherita Rosnati , Melanie Roschewitz , Ben Glocker

Recent advancements in diffusion models have demonstrated significant success in unsupervised anomaly segmentation. For anomaly segmentation, these models are first trained on normal data; then, an anomalous image is noised to an…

Computer Vision and Pattern Recognition · Computer Science 2025-08-08 Mehrdad Moradi , Kamran Paynabar

Deep generative models (DGM) are neural networks with many hidden layers trained to approximate complicated, high-dimensional probability distributions using a large number of samples. When trained successfully, we can use the DGMs to…

Machine Learning · Computer Science 2021-04-13 Lars Ruthotto , Eldad Haber

Diffusion Probabilistic Models (DPMs) are powerful generative models that have achieved unparalleled success in a number of generative tasks. In this work, we aim to build inductive biases into the training and sampling of diffusion models…

Machine Learning · Computer Science 2025-03-14 Thomas Jiralerspong , Berton Earnshaw , Jason Hartford , Yoshua Bengio , Luca Scimeca

Diffusion Language Models (DLMs) provide a promising alternative to autoregressive language models by generating text through iterative denoising and bidirectional refinement. However, this iterative generation paradigm also introduces…

Computation and Language · Computer Science 2026-05-14 Yejin Lee , Yo-Sub Han

Guided or controlled data generation with diffusion models\blfootnote{Partial preliminary results of this work appeared in International Conference on Machine Learning 2025 \citep{li2025provable}.} has become a cornerstone of modern…

Machine Learning · Statistics 2025-12-05 Yuchen Jiao , Yuxin Chen , Gen Li

Generative AI has received significant attention among a spectrum of diverse industrial and academic domains, thanks to the magnificent results achieved from deep generative models such as generative pre-trained transformers (GPT) and…

Information Theory · Computer Science 2023-10-06 Mehdi Letafati , Samad Ali , Matti Latva-aho

Diffusion models are a class of flexible generative models trained with an approximation to the log-likelihood objective. However, most use cases of diffusion models are not concerned with likelihoods, but instead with downstream objectives…

Machine Learning · Computer Science 2024-01-08 Kevin Black , Michael Janner , Yilun Du , Ilya Kostrikov , Sergey Levine

Discrete diffusion models have recently emerged as a promising alternative to the autoregressive approach for generating discrete sequences. Sample generation via gradual denoising or demasking processes allows them to capture hierarchical…

Diverse human motion prediction (HMP) aims to predict multiple plausible future motions given an observed human motion sequence. It is a challenging task due to the diversity of potential human motions while ensuring an accurate description…

Computer Vision and Pattern Recognition · Computer Science 2024-09-04 Hua Yu , Yaqing Hou , Wenbin Pei , Qiang Zhang

Image generation using diffusion can be controlled in multiple ways. In this paper, we systematically analyze the equations of modern generative diffusion networks to propose a framework, called MDP, that explains the design space of…

Computer Vision and Pattern Recognition · Computer Science 2023-03-31 Qian Wang , Biao Zhang , Michael Birsak , Peter Wonka

Masked discrete diffusion models (MDMs) are a promising new approach to generative modelling, offering the ability for parallel token generation and therefore greater efficiency than autoregressive counterparts. However, achieving an…

Machine Learning · Computer Science 2026-03-02 David Fox , Sam Bowyer , Song Liu , Laurence Aitchison , Raul Santos-Rodriguez , Mengyue Yang

Joint-embedding predictive architectures (JEPAs) have shown substantial promise in self-supervised representation learning, yet their application in generative modeling remains underexplored. Conversely, diffusion models have demonstrated…

Machine Learning · Computer Science 2025-02-05 Dengsheng Chen , Jie Hu , Xiaoming Wei , Enhua Wu

Diffusion models achieve state-of-the-art image generation but remain computationally costly due to iterative denoising. Latent-space models like Stable Diffusion reduce overhead yet lose fine detail, while retrieval-augmented methods…

Machine Learning · Computer Science 2025-12-23 Bilal Faye , Hanane Azzag , Mustapha Lebbah
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