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Cellular morphodynamics requires solving systems of coupled partial differential equations on moving bulk and surface domains, where advection-dominant transport, structure preservation, and severe mesh distortions make robust simulation…

Numerical Analysis · Mathematics 2026-01-12 Alessandro Contri , André Massing , Padmini Rangamani

We propose and investigate a model for lipid raft formation and dynamics in biological membranes. The model describes the lipid composition of the membrane and an interaction with cholesterol. To account for cholesterol exchange between…

Analysis of PDEs · Mathematics 2016-03-15 Harald Garcke , Johannes Kampmann , Andreas Rätz , Matthias Röger

The filtration membranes are often elaborated through a phase separation process where a polymer rich phase and a polymer poor phase spontaneously form through spinodal decomposition. One process that is still not well understood from a…

Many cellular organelles are membrane-bound structures with complex membrane composition and shape. Their shapes have been observed to depend on the metabolic state of the organelle, and the mechanisms that couple biochemical pathways and…

Soft Condensed Matter · Physics 2023-07-19 Toni V. Mendes , Jonas Ranft , Hélène Berthoumieux

The phase diagram of a binary fluid mixture of highly asymmetric additive hard spheres is investigated. Demixing is analyzed from the exact low-density expansions of the thermodynamic properties of the mixture and compared with the…

Soft Condensed Matter · Physics 2007-05-23 C. F. Tejero , M. Lopez de Haro

We discuss the dynamics of a bilayer membrane with partial slip boundary conditions between the monolayers and the bulk fluid. Using Onsager's variational principle to account for the associated dissipations, we derive the coupled dynamic…

Soft Condensed Matter · Physics 2018-07-18 Kento Yasuda , Ryuichi Okamoto , Shigeyuki Komura , Jean-Baptiste Fournier

We present a simple and computationally efficient coarse-grained and solvent-free model for simulating lipid bilayer membranes. In order to be used in concert with particle-based reaction-diffusion simulations, the model is purely based on…

Biological Physics · Physics 2018-01-31 Mohsen Sadeghi , Thomas R. Weikl , Frank Noé

In any number of space variables, we study the Cauchy problem related to the thin-film equation in the simplest case of a linearly degenerate mobility. This equation, derived from a lubrication approximation, also models the surface tension…

Analysis of PDEs · Mathematics 2013-10-24 Dominik John

Phase separation under directional quenching has been studied in a Cahn-Hilliard model. In distinct contrast to the disordered patterns which develop under a homogeneous quench periodic stripe patterns are generated behind the quench front.…

Pattern Formation and Solitons · Physics 2009-11-13 Alexei Krekhov

A phenomenological model for the unbinding transition of multi-component fluid membranes is proposed, where the unbinding transition is described using a theory analogous to Flory-Huggins theory for polymers. The coupling between the…

Soft Condensed Matter · Physics 2009-11-07 Shigeyugi Komura , David Andelman

In this work, we analytically investigate a degenerating PDE system for phase separation and complete damage processes considered on a nonsmooth time-dependent domain with mixed boundary conditions. The evolution of the system is described…

Analysis of PDEs · Mathematics 2016-09-16 Christian Heinemann , Christiane Kraus

Multiphase poromechanics describes the evolution of multiphase flow in deformable porous media. Mathematical models for such multiphysics system are inheritely nonlinear, potentially degenerate and fully coupled systems of partial…

Analysis of PDEs · Mathematics 2023-12-05 Jakub Wiktor Both , Clément Cancès

We present a novel platform for the large-scale simulation of fibrous structures immersed in a Stokesian fluid and evolving under confinement or in free-space. One of the main motivations for this work is to study the dynamics of fiber…

Numerical Analysis · Mathematics 2017-01-04 Ehssan Nazockdast , Abtin Rahimian , Denis Zorin , Michael Shelley

We numerically investigate the hydrodynamics and membrane dynamics of multicomponent vesicles in two strongly confined geometries. This serves as a simplified model for red blood cells undergoing large deformations while traversing narrow…

Soft Condensed Matter · Physics 2023-08-21 Ashley Gannon , Bryan Quaife , Y. -N. Young

A mesoscopic coarse-grain model for computationally-efficient simulations of biomembranes is presented. It combines molecular dynamics simulations for the lipids, modeled as elastic chains of beads, with multiparticle collision dynamics for…

Soft Condensed Matter · Physics 2015-06-04 Mu-Jie Huang , Raymond Kapral , Alexander S. Mikhailov , Hsuan-Yi Chen

We consider a system which consists of a Cahn-Hilliard equation coupled with a Cahn-Hilliard-Oono equation in a bounded domain of $\mathbb{R}^d$, $d = 2, 3$. This system accounts for macrophase and microphase separation in a polymer mixture…

Analysis of PDEs · Mathematics 2022-03-25 Andrea Di Primio , Maurizio Grasselli

In this work, a ternary phase-field model for two-phase flows in complex geometries is proposed. In this model, one of the three components in the classical ternary Cahn-Hilliard model is considered as the solid phase, and only one…

Fluid Dynamics · Physics 2024-07-04 Chengjie Zhan , Zhenhua Chai , Baochang Shi

A number of important results of studying large deformations of hyper-elastic shells are obtained using discrete methods of mathematical physics. In the present paper, using the variational method for solving nonlinear boundary problems of…

Analysis of PDEs · Mathematics 2015-06-26 V. A. Trotsenko

The phase behavior of colloidal particles embedded in a binary fluid is influenced by wetting layers surrounding each particle. The free energy of the fluid film depends on its morphology, i.e., on size, shape and connectivity. Under rather…

Soft Condensed Matter · Physics 2007-05-23 Uwe Brodatzki , Klaus Mecke

In traditional phase-field modeling of multiphase materials, a significant challenge arises from the non-local nature of fracture energy regularization, where interfacial toughness is inherently coupled with the properties of the…

Computational Physics · Physics 2026-04-14 Ye-Hang Qin , Ye Feng