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We investigate how an externally imposed curvature influences lipid segregation on two-phase-coexistent membranes. We show that the bending-modulus contrast of the two phases and the curvature act together to yield a reduced effective line…

Soft Condensed Matter · Physics 2018-06-21 Fangfu Ye , Robin L. B. Selinger , Jonathan V. Selinger

We model the spatiotemporal dynamics of cellular protein concentrations near membranes composed of different lipids using a three-variable continuum model for membrane-bound protein, cytosolic protein, and the local composition of a binary…

Soft Condensed Matter · Physics 2026-03-26 Benjamin Winkler , Sergio Alonso , Markus Bär

We study a model of a lipid bilayer membrane described by two order parameters: the chemical composition described using the Gaussian model and the spatial configuration described with the elastic deformation model of a membrane with a…

Soft Condensed Matter · Physics 2022-06-08 Piotr Nowakowski , Bernd Henning Stumpf , Ana-Sunčana Smith , Anna Maciołek

Biomembranes play a central role in various phenomena like locomotion of cells, cell-cell interactions, packaging of nutrients, and in maintaining organelle morphology and functionality. During these processes, the membranes undergo…

Quantitative Methods · Quantitative Biology 2021-12-01 Debabrata Auddya , Xiaoxuan Zhang , Rahul Gulati , Ritvik Vasan , Krishna Garikipati , Padmini Rangamani , Shiva Rudraraju

A novel two-leaflet description of lipid membranes is proposed. Within its framework, phase separation phenomena in multicomponent biological membranes are analyzed. As we show, interactions between the leaflets tend to suppress macroscopic…

Biological Physics · Physics 2016-02-03 Ramon Reigada , Alexander S. Mikhailov

The Cahn-Hilliard equation is a fundamental model that describes the phase separation process in multi-component mixtures. It has been successfully extended to many different contexts in several scientific fields. In this survey article, we…

Analysis of PDEs · Mathematics 2022-06-22 Hao Wu

In this work, we study the adhesion of multi-component vesicle membrane to both flat and curved substrates, based on the conventional Helfrich bending energy for multi-component vesicles and adhesion potentials of different forms. A phase…

Biological Physics · Physics 2015-05-14 Yanxiang Zhao , Sovan Das , Qiang Du

The study of vesicles in suspension is important to understand the complicated dynamics exhibited by cells in vivo and in vitro. We developed a computer simulation based on the boundary-integral method to model the three dimensional…

Biological Physics · Physics 2013-07-24 Ivan Rey Suarez , Chad Leidy , Gabriel Tellez , Guillaume Gay , Andres Gonzalez-Mancera

The deformation of an initially spherical capsule, freely suspended in simple shear flow, can be computed analytically in the limit of small deformations [D. Barthes-Biesel, J. M. Rallison, The Time-Dependent Deformation of a Capsule Freely…

Soft Condensed Matter · Physics 2010-08-10 Timm Krüger , Fathollah Varnik , Dierk Raabe

We study an evolutionary system of Cahn-Hilliard-Darcy type including mass source and transport effects. The system may arise in a number of physical situations related to phase separation phenomena with convection, with the main and most…

Analysis of PDEs · Mathematics 2022-02-24 Giulio Schimperna

This paper presents a phase-field model for simulating the three-dimensional deformation of vesicle membranes, incorporating area-difference elasticity, with constraints on bulk volume and surface area. We develop efficient numerical…

Numerical Analysis · Mathematics 2025-11-19 Yihong Liang , Emine Celiker , Ping Lin

At high temperature and pressure, solid diffusion and chemical reactions between rock minerals lead to phase transformations. Chemical transport during uphill diffusion causes phase separation, that is, spinodal decomposition. Thus, to…

Geophysics · Physics 2021-09-01 Santiago P. Clavijo , Luis Espath , Victor M. Calo

Giant unilamellar vesicles (GUVs) composed of as few as three lipid species can phase separate into small-scale lipid domains with stripes and dots patterns. These patterns have been experimentally characterized in terms of how their size…

Soft Condensed Matter · Physics 2025-05-21 Qiwei Yu , Andrej Košmrlj

The Cahn-Hilliard equation is the most common model to describe phase separation processes of a mixture of two components. For a better description of short-range interactions of the material with the solid wall, various dynamic boundary…

Analysis of PDEs · Mathematics 2020-10-20 Harald Garcke , Patrik Knopf

A systematic investigation of the phase separation dynamics in self-assembled multi-component bilayer fluid vesicles and open membranes is presented. We use large-scale dissipative particle dynamics to explicitly account for solvent,…

Soft Condensed Matter · Physics 2015-06-25 Mohamed Laradji , P. B. Sunil Kumar

The mathematical analysis of diffuse-interface models for multiphase flows has attracted significant attention due to their ability to capture complex interfacial dynamics, including curvature effects, within a unified, energetically…

Analysis of PDEs · Mathematics 2025-09-25 Pierluigi Colli , Gianni Gilardi , Andrea Signori , Jürgen Sprekels

We consider a well known model for lipid-bilayer membrane vesicles exhibiting phase separation, incorporating a phase field with finite curvature elasticity. We prove the existence of a plethora of equilibria, corresponding to…

Analysis of PDEs · Mathematics 2018-12-11 Timothy J. Healey , Sanjay Dharmavaram

We study the well-posedness of a modified degenerate Cahn-Hilliard type model for surface diffusion. With degenerate phase-dependent diffusion mobility and additional stabilizing function, this model is able to give the correct sharp…

Analysis of PDEs · Mathematics 2022-04-19 Xiaohua Niu , Yang Xiang , Xiaodong Yan

We consider a model of a biomembrane with attached proteins. The membrane is represented by a near spherical continuous surface and attached proteins are described as discrete rigid structures which attach to the membrane at a finite number…

Analysis of PDEs · Mathematics 2021-12-14 Charles M. Elliott , Philip J. Herbert

Room temperature ionic liquids are attractive to numerous applications and particularly, to renewable energy devices. As solvent free electrolytes, they demonstrate a paramount connection between the material morphology and Coulombic…

Chemical Physics · Physics 2016-03-15 Nir Gavish , Arik Yochelis
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