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In biology, cells undergo deformations under the action of flow caused by the fluid surrounding them. These flows lead to shape changes and instabilities that have been explored in detail for single component vesicles. However, cell…

Fluid Dynamics · Physics 2025-10-15 Anirudh Venkatesh , Vivek Narsimhan

We present a stochastic phase-field model for multicomponent lipid bilayers that explicitly accounts for the quasi-two-dimensional hydrodynamic environment unique to a thin fluid membrane immersed in aqueous solution. Dynamics over a wide…

Soft Condensed Matter · Physics 2011-05-26 Brian A. Camley , Frank L. H. Brown

We present a new mechanochemical modeling framework to explore the shape deformation and pattern formation in multicomponent vesicle membranes. In this framework, the shape of the membrane is described by an elastic bending model, while…

Mathematical Physics · Physics 2025-10-06 Wangbo Luo , Zhonghua Qiao , Yanxiang Zhao

We present extensive results from 2-dimensional simulations of phase separation kinetics in a model with order-parameter dependent mobility. We find that the time-dependent structure factor exhibits dynamical scaling and the scaling…

Condensed Matter · Physics 2009-10-30 Sanjay Puri , Alan Bray , Joel Lebowitz

We consider a diffuse interface model that describes the macro- and micro-phase separation processes of a polymer mixture. The resulting system consists of a Cahn-Hilliard equation and a Cahn-Hilliard-Oono type equation endowed with the…

Analysis of PDEs · Mathematics 2024-05-01 Bohan Ouyang

We consider a class of Cahn-Hilliard equation that characterizes phase separation phenomena of binary mixtures in a bounded domain $\Omega \subset \mathbb{R}^d$ $(d\in \{2,3\})$ with non-permeable boundary. The equations in the bulk are…

Analysis of PDEs · Mathematics 2024-06-03 Maoyin Lv , Hao Wu

We consider a Canham-Helfrich-type variational problem defined over closed surfaces enclosing a fixed volume and having fixed surface area. The problem models the shape of multiphase biomembranes. It consists of minimizing the sum of the…

Mathematical Physics · Physics 2012-05-01 Rustum Choksi , Marco Morandotti , Marco Veneroni

We address the minimization of the Canham-Helfrich functional in presence of multiple phases. The problem is inspired by the modelization of heterogeneous biological membranes, which may feature variable bending rigidities and spontaneous…

Analysis of PDEs · Mathematics 2020-03-06 Katharina Brazda , Luca Lussardi , Ulisse Stefanelli

Heterogeneities in the cell membrane due to coexisting lipid phases have been conjectured to play a major functional role in cell signaling and membrane trafficking. Thereby the material properties of multiphase systems, such as the line…

Soft Condensed Matter · Physics 2013-04-17 Stefan Semrau , Timon Idema , Laurent Holtzer , Thomas Schmidt , Cornelis Storm

We address the geometric Cauchy problem for surfaces associated to the membrane shape equation describing equilibrium configurations of vesicles formed by lipid bilayers. This is the Euler-Lagrange equation of the Canham-Helfrich-Evans…

Differential Geometry · Mathematics 2014-11-18 Gary R. Jensen , Emilio Musso , Lorenzo Nicolodi

The Helfrich energy is commonly used to model the elastic bending energy of lipid bilayers in membrane mechanics. The governing differential equations for certain geometric characteristics of the shape of the membrane can be obtained by…

Numerical Analysis · Mathematics 2020-05-27 P. Rangamani , A. Behzadan , M. Holst

We theoretically study the elastic deformation of a fluid membrane induced by an adhering spherical colloidal particle within the framework of a Helfrich energy. Based on a full optimization of the membrane shape we find a continuous…

Soft Condensed Matter · Physics 2009-11-07 Markus Deserno , Thomas Bickel

The evolution of the microstructure due to spinodal decomposition in phase separated mixtures has a strong impact on the final material properties. In the late stage of coarsening, the system is characterized by the growth of a single…

Soft Condensed Matter · Physics 2021-12-09 Björn König , Olivier J. J. Ronsin , Jens Harting

We consider a discrete-continuum model of a biomembrane with embedded particles. While the membrane is represented by a continuous surface, embedded particles are described by rigid discrete objects which are free to move and rotate in…

Analysis of PDEs · Mathematics 2021-04-29 Tobias Kies , Carsten Gräser

The Cahn--Hilliard equation is a widely used model that describes amongst others phase separation processes of binary mixtures or two-phase flows. In the recent years, different types of boundary conditions for the Cahn--Hilliard equation…

Numerical Analysis · Mathematics 2021-03-04 Stefan Metzger

In this paper we present a mathematical model to describe the phenomenon of phase separation, which is modelled as space regions where an order parameter changes smoothly. The model proposed, including thermal and mixing effects, is deduced…

Mathematical Physics · Physics 2011-02-08 Alessia Berti , Ivana Bochicchio

The Cahn--Hilliard equation is a fundamental model that describes phase separation processes of binary mixtures. In recent years, several types of dynamic boundary conditions have been proposed in order to account for possible short-range…

Analysis of PDEs · Mathematics 2023-07-28 Chun Liu , Hao Wu

This work studies the nonlocal Cahn Hilliard Brinkman system, which models the phase separation of a binary fluid in a bounded domain and porous media. We focus on a system with a singular potential namely logarithmic form and a degenerate…

Analysis of PDEs · Mathematics 2025-02-07 Sheetal Dharmatti , Greeshma K

Motivated by recent experimental work on multicomponent lipid membranes supported by colloidal scaffolds, we report an exhaustive theoretical investigation of the equilibrium configurations of binary mixtures on curved substrates. Starting…

Soft Condensed Matter · Physics 2018-09-12 Piermarco Fonda , Melissa Rinaldin , Daniela J. Kraft , Luca Giomi

In this paper, phase field models are developed for multi-component vesicle membranes with different lipid compositions and membranes with free boundary. These models are used to simulate the deformation of membranes under the elastic…

Biological Physics · Physics 2007-05-23 Xiaoqiang Wang , Qiang Du