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LLMs have demonstrated impressive performance in answering medical questions, such as achieving passing scores on medical licensing examinations. However, medical board exams or general clinical questions do not capture the complexity of…

Computation and Language · Computer Science 2026-02-19 Hanjie Chen , Zhouxiang Fang , Yash Singla , Mark Dredze

Large language models with reasoning capabilities have demonstrated impressive performance across a wide range of domains. In clinical applications, a transparent, step-by-step reasoning process provides physicians with strong evidence to…

Artificial Intelligence · Computer Science 2025-12-16 Linjie Mu , Yannian Gu , Zhongzhen Huang , Yakun Zhu , Shaoting Zhang , Xiaofan Zhang

Large language models perform well on static medical examinations, yet clinical diagnosis often requires iterative evidence gathering under uncertainty. Building on prior interactive evaluation efforts, we introduce an OSCE-inspired…

Artificial Intelligence · Computer Science 2026-05-22 Chen Zhan , Xihe Qiu , Xiaoyu Tan , Xibing Zhuang , Gengchen Ma , Yue Zhang , Shuo Li , Peifeng Liu , Xiaoxiao Ge , Liang Liu , Lu Gan

Clinical check-up reports are multimodal documents that combine page layouts, tables, numerical biomarkers, abnormality flags, imaging findings, and domain-specific terminology. Such heterogeneous evidence is difficult for laypersons to…

Computation and Language · Computer Science 2026-05-14 Sike Xiang , Shuang Chen , Kevin Qinghong Lin , Jialin Yu , Yijia Sun , Philip Torr , Amir Atapour-Abarghouei

Large language model (LLM) systems are increasingly used to support high-stakes decision-making, but they typically perform worse when the available evidence is internally inconsistent. Such a scenario exists in real-world healthcare…

Computation and Language · Computer Science 2026-04-02 Haochen Liu , Weien Li , Rui Song , Zeyu Li , Chun Jason Xue , Xiao-Yang Liu , Sam Nallaperuma , Xue Liu , Ye Yuan

Developing conversational agents to interact with patients and provide primary clinical advice has attracted increasing attention due to its huge application potential, especially in the time of COVID-19 Pandemic. However, the training of…

Computation and Language · Computer Science 2022-08-02 Wenge Liu , Jianheng Tang , Yi Cheng , Wenjie Li , Yefeng Zheng , Xiaodan Liang

Traditionally, a debate usually requires a manual preparation process, including reading plenty of articles, selecting the claims, identifying the stances of the claims, seeking the evidence for the claims, etc. As the AI debate attracts…

Computation and Language · Computer Science 2022-07-19 Liying Cheng , Lidong Bing , Ruidan He , Qian Yu , Yan Zhang , Luo Si

Medical conversational AI (AI) plays a pivotal role in the development of safer and more effective medical dialogue systems. However, existing benchmarks and evaluation frameworks for assessing the information-gathering and diagnostic…

Computation and Language · Computer Science 2026-01-08 Lecheng Gong , Weimin Fang , Ting Yang , Dongjie Tao , Chunxiao Guo , Peng Wei , Bo Xie , Jinqun Guan , Zixiao Chen , Fang Shi , Jinjie Gu , Junwei Liu

Healthcare and medicine are multimodal disciplines that deal with multimodal data for reasoning and diagnosing multiple diseases. Although some multimodal reasoning models have emerged for reasoning complex tasks in scientific domains,…

Artificial Intelligence · Computer Science 2025-09-16 Susanta Mitra

There is a growing need to understand how digital systems can support clinical decision-making, particularly as artificial intelligence (AI) models become increasingly complex and less human-interpretable. This complexity raises concerns…

Reasoning-based large language models have excelled in mathematics and programming, yet their potential in knowledge-intensive medical question answering remains underexplored and insufficiently validated in clinical contexts. To bridge…

Computation and Language · Computer Science 2025-10-10 Yu Sun , Xingyu Qian , Weiwen Xu , Hao Zhang , Chenghao Xiao , Long Li , Deli Zhao , Wenbing Huang , Tingyang Xu , Qifeng Bai , Yu Rong

Publicly accessible benchmarks that allow for assessing and comparing model performances are important drivers of progress in artificial intelligence (AI). While recent advances in AI capabilities hold the potential to transform medical…

Artificial Intelligence · Computer Science 2022-12-26 Kathrin Blagec , Jakob Kraiger , Wolfgang Frühwirt , Matthias Samwald

AI-driven clinical text classification is vital for explainable automated retrieval of population-level health information. This work investigates whether human-based clinical rationales can serve as additional supervision to improve both…

Computation and Language · Computer Science 2025-07-30 Christoph Metzner , Shang Gao , Drahomira Herrmannova , Heidi A. Hanson

Multimodal artificial intelligence (AI) systems have the potential to enhance clinical decision-making by interpreting various types of medical data. However, the effectiveness of these models across all medical fields is uncertain. Each…

In recent years, AI systems in the medical domain have advanced significantly. However, despite outperforming humans, they are rarely used in practice since it is often not clear how they make their decisions. Optimal explanation and…

Human-Computer Interaction · Computer Science 2026-05-06 Julia Wagner , Tim Schlippe

Understanding causality has vital importance for various Natural Language Processing (NLP) applications. Beyond the labeled instances, conceptual explanations of the causality can provide deep understanding of the causal facts to facilitate…

Artificial Intelligence · Computer Science 2022-05-13 Li Du , Xiao Ding , Kai Xiong , Ting Liu , Bing Qin

Explainability is a critical factor in enhancing the trustworthiness and acceptance of artificial intelligence (AI) in healthcare, where decisions directly impact patient outcomes. Despite advancements in AI interpretability, clear…

Artificial Intelligence · Computer Science 2025-05-15 Michail Mamalakis , Héloïse de Vareilles , Graham Murray , Pietro Lio , John Suckling

Integrating large language models (LLMs) like DeepSeek R1 into healthcare requires rigorous evaluation of their reasoning alignment with clinical expertise. This study assesses DeepSeek R1's medical reasoning against expert patterns using…

Computation and Language · Computer Science 2025-04-02 Birger Moell , Fredrik Sand Aronsson , Sanian Akbar

The emergence of groundbreaking large language models capable of performing complex reasoning tasks holds significant promise for addressing various scientific challenges, including those arising in complex clinical scenarios. To enable…

Computation and Language · Computer Science 2025-05-30 Yakun Zhu , Zhongzhen Huang , Linjie Mu , Yutong Huang , Wei Nie , Jiaji Liu , Shaoting Zhang , Pengfei Liu , Xiaofan Zhang

Automated fact-checking systems verify claims against evidence to predict their veracity. In real-world scenarios, the retrieved evidence may not unambiguously support or refute the claim and yield conflicting but valid interpretations.…

Computation and Language · Computer Science 2023-12-15 Max Glockner , Ieva Staliūnaitė , James Thorne , Gisela Vallejo , Andreas Vlachos , Iryna Gurevych