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Phenotype-driven gene prioritization is a critical process in the diagnosis of rare genetic disorders for identifying and ranking potential disease-causing genes based on observed physical traits or phenotypes. While traditional approaches…

Quantitative Methods · Quantitative Biology 2024-04-04 Junyoung Kim , Jingye Yang , Kai Wang , Chunhua Weng , Cong Liu

Large Language Models (LLMs), with their remarkable ability to tackle challenging and unseen reasoning problems, hold immense potential for tabular learning, that is vital for many real-world applications. In this paper, we propose a novel…

Machine Learning · Computer Science 2024-05-07 Sungwon Han , Jinsung Yoon , Sercan O Arik , Tomas Pfister

The intricate relationship between genetic variation and human diseases has been a focal point of medical research, evidenced by the identification of risk genes regarding specific diseases. The advent of advanced genome sequencing…

Quantitative Methods · Quantitative Biology 2024-01-19 Jiayu Chang , Shiyu Wang , Chen Ling , Zhaohui Qin , Liang Zhao

Large Vision-Language Models (LVLMs) have shown impressive capabilities across a range of tasks that integrate visual and textual understanding, such as image captioning and visual question answering. These models are trained on large-scale…

Computer Vision and Pattern Recognition · Computer Science 2026-03-11 Xiaomei Zhang , Hanyu Zheng , Xiangyu Zhu , Jinghuan Wei , Junhong Zou , Zhen Lei , Zhaoxiang Zhang

Feature engineering for tabular data remains a critical yet challenging step in machine learning. Recently, large language models (LLMs) have been used to automatically generate new features by leveraging their vast knowledge. However,…

Artificial Intelligence · Computer Science 2025-06-26 Sungwon Han , Sungkyu Park , Seungeon Lee

Current knowledge graph (KG) construction methods are confirmatory, focusing on recovering known relationships rather than identifying novel or context-dependent nodes. This paper proposes a phenotype-driven and evidence-governed framework…

Artificial Intelligence · Computer Science 2026-04-21 Adela Bâra , Simona-Vasilica Oprea

Emerging topics in biomedical research are continuously expanding, providing a wealth of information about genes and their function. This rapid proliferation of knowledge presents unprecedented opportunities for scientific discovery and…

Genomics · Quantitative Biology 2024-12-25 Zhijian Chen , Chuan Hu , Min Wu , Qingqing Long , Xuezhi Wang , Yuanchun Zhou , Meng Xiao

The rapid advancement of Large Language Models (LLMs) has significantly influenced various domains, leveraging their exceptional few-shot and zero-shot learning capabilities. In this work, we aim to explore and understand the LLMs-based…

Artificial Intelligence · Computer Science 2024-10-24 Dawei Li , Zhen Tan , Huan Liu

Automated feature engineering plays a critical role in improving predictive model performance for tabular learning tasks. Traditional automated feature engineering methods are limited by their reliance on pre-defined transformations within…

Machine Learning · Computer Science 2026-05-12 Nikhil Abhyankar , Parshin Shojaee , Chandan K. Reddy

In this paper, we demonstrate a surprising capability of large language models (LLMs): given only input feature names and a description of a prediction task, they are capable of selecting the most predictive features, with performance…

Machine Learning · Computer Science 2025-04-21 Daniel P. Jeong , Zachary C. Lipton , Pradeep Ravikumar

Distilling underlying principles from data has historically driven scientific breakthroughs. However, conventional data-driven machine learning often produces complex models that lack interpretability and generalization due to insufficient…

Materials Science · Physics 2025-07-28 Zhilong Song , Qionghua Zhou , Chunjin Ren , Chongyi Ling , Minggang Ju , Jinlan Wang

In tabular prediction tasks, tree-based models combined with automated feature engineering methods often outperform deep learning approaches that rely on learned representations. While these feature engineering techniques are effective,…

Machine Learning · Computer Science 2024-11-19 Jaehyun Nam , Kyuyoung Kim , Seunghyuk Oh , Jihoon Tack , Jaehyung Kim , Jinwoo Shin

Feature transformation aims to reconstruct the feature space of raw features to enhance the performance of downstream models. However, the exponential growth in the combinations of features and operations poses a challenge, making it…

Machine Learning · Computer Science 2024-12-19 Nanxu Gong , Chandan K. Reddy , Wangyang Ying , Haifeng Chen , Yanjie Fu

Recent advancements in large language models (LLMs) have shown promise in feature engineering for tabular data, but concerns about their reliability persist, especially due to variability in generated outputs. We introduce a multi-level…

Machine Learning · Computer Science 2025-10-01 Yebin Lim , Susik Yoon

Modern engineering increasingly relies on vast datasets generated by experiments and simulations, driving a growing demand for efficient, reliable, and broadly applicable modeling strategies. There is also heightened interest in developing…

Artificial Intelligence · Computer Science 2025-10-03 Yang Liu , Zaid Abulawi , Abhiram Garimidi , Doyeong Lim

Recent advances in large language models (LLMs) have provided new opportunities for decision-making, particularly in the task of automated feature selection. In this paper, we first comprehensively evaluate LLM-based feature selection…

Machine Learning · Computer Science 2025-12-12 Jianhao Li , Xianchao Xiu

The linking genotype to phenotype is the fundamental aim of modern genetics. We focus on study of links between gene expression data and phenotype data through integrative analysis. We propose three approaches. 1) The inherent complexity of…

Quantitative Methods · Quantitative Biology 2015-06-30 Min Xu

The applications of large language models (LLMs) are promising for biomedical and healthcare research. Despite the availability of open-source LLMs trained using a wide range of biomedical data, current research on the applications of LLMs…

Machine Learning · Computer Science 2024-09-25 Tianyu Liu , Yijia Xiao , Xiao Luo , Hua Xu , W. Jim Zheng , Hongyu Zhao

Fine-tuning for large language models (LLMs) typically requires substantial amounts of high-quality supervised data, which is both costly and labor-intensive to acquire. While synthetic data generation has emerged as a promising solution,…

Computation and Language · Computer Science 2025-05-28 Zihong Chen , Wanli Jiang , Jinzhe Li , Zhonghang Yuan , Huanjun Kong , Wanli Ouyang , Nanqing Dong

Existing feature engineering methods based on large language models (LLMs) have not yet been applied to multi-label learning tasks. They lack the ability to model complex label dependencies and are not specifically adapted to the…

Machine Learning · Computer Science 2025-12-18 Wanfu Gao , Zebin He , Jun Gao
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