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In the rapidly evolving landscape of genomics, deep learning has emerged as a useful tool for tackling complex computational challenges. This review focuses on the transformative role of Large Language Models (LLMs), which are mostly based…

Large language models (LLMs) have been widely adopted due to their remarkable performance across various applications, driving the accelerated development of a large number of diverse models. However, these individual LLMs show limitations…

Computation and Language · Computer Science 2025-06-13 Kaushal Kumar Maurya , KV Aditya Srivatsa , Ekaterina Kochmar

This paper presents a framework for predicting rare, high-impact outcomes by integrating large language models (LLMs) with a multi-model machine learning (ML) architecture. The approach combines the predictive strength of black-box models…

Machine Learning · Computer Science 2025-09-11 Mihir Kumar , Aaron Ontoyin Yin , Zakari Salifu , Kelvin Amoaba , Afriyie Kwesi Samuel , Fuat Alican , Yigit Ihlamur

Tabular data high-stakes critical decision-making in domains such as finance, healthcare, and scientific discovery. Yet, learning effectively from tabular data in few-shot settings, where labeled examples are scarce, remains a fundamental…

Machine Learning · Computer Science 2026-01-19 Zhihan Yang , Jiaqi Wei , Xiang Zhang , Haoyu Dong , Yiwen Wang , Xiaoke Guo , Pengkun Zhang , Yiwei Xu , Chenyu You

Pre-trained large language models(LLMs) have attracted increasing attention in biomedical domains due to their success in natural language processing. However, the complex traits and heterogeneity of multi-sources genomics data pose…

Computation and Language · Computer Science 2025-11-25 Yanjun Lyu , Zihao Wu , Lu Zhang , Jing Zhang , Yiwei Li , Wei Ruan , Zhengliang Liu , Zeyu Zhang , Xiang Li , Rongjie Liu , Chao Huang , Wentao Li , Tianming Liu , Dajiang Zhu

Predicting phenotypes from gene expression data is a crucial task in biomedical research, enabling insights into disease mechanisms, drug responses, and personalized medicine. Traditional machine learning and deep learning rely on…

Machine Learning · Computer Science 2025-09-18 Kevin Dradjat , Massinissa Hamidi , Pierre Bartet , Blaise Hanczar

In healthcare tabular predictions, classical models with feature engineering often outperform neural approaches. Recent advances in Large Language Models enable the integration of domain knowledge into feature engineering, offering a…

Machine Learning · Computer Science 2026-03-04 Zizheng Zhang , Yiming Li , Justin Xu , Jinyu Wang , Rui Wang , Lei Song , Jiang Bian , David W Eyre , Jingjing Fu

One of the key tasks in machine learning for tabular data is feature engineering. Although it is vital for improving the performance of models, it demands considerable human expertise and deep domain knowledge, making it labor-intensive…

Computation and Language · Computer Science 2025-04-01 Jeonghyun Ko , Gyeongyun Park , Donghoon Lee , Kyunam Lee

We introduce LLM-Lasso, a novel framework that leverages large language models (LLMs) to guide feature selection in Lasso $\ell_1$ regression. Unlike traditional methods that rely solely on numerical data, LLM-Lasso incorporates…

Rare disease diagnosis requires matching variant-bearing genes to complex patient phenotypes across large and heterogeneous evidence sources. This process remains time-intensive in current clinical interpretation pipelines. To overcome…

Genomics · Quantitative Biology 2026-03-09 Jaeyeon Lee , Lin Yao , Hyun-Hwan Jeong , Zhandong Liu

Evolutionary methods have long been useful for analysis and explanation in genetics, biology, ecology, and related fields. In this work, we extend these methods to neural networks, specifically large language models (LLMs), to better…

Neural and Evolutionary Computing · Computer Science 2026-05-06 Shannon K. Gallagher , Swati Rallapalli , Tyler Brooks , Chuck Loughin , Michele Sezgin , Ronald Yurko

Interpreting data is central to modern research. Large language models (LLMs) show promise in providing such natural language interpretations of data, yet simple feature extraction methods such as prompting often fail to produce accurate…

Artificial Intelligence · Computer Science 2025-05-30 Michal Bravansky , Vaclav Kubon , Suhas Hariharan , Robert Kirk

The performance of machine learning models on tabular data is critically dependent on high-quality feature engineering. While Large Language Models (LLMs) have shown promise in automating feature extraction (AutoFE), existing methods are…

Artificial Intelligence · Computer Science 2025-11-20 Henrik Bradland , Morten Goodwin , Vladimir I. Zadorozhny , Per-Arne Andersen

Materials design often relies on human-generated hypotheses, a process inherently limited by cognitive constraints such as knowledge gaps and limited ability to integrate and extract knowledge implications, particularly when…

Can we leverage LLMs to model the process of discovering novel language model (LM) architectures? Inspired by real research, we propose a multi-agent LLM approach that simulates the conventional stages of research, from ideation and…

Artificial Intelligence · Computer Science 2025-06-26 Junyan Cheng , Peter Clark , Kyle Richardson

Conventional mechanical design follows an iterative process in which initial concepts are refined through cycles of expert assessment and resource-intensive Finite Element Method (FEM) analysis to meet performance goals. While machine…

Machine Learning · Computer Science 2025-05-02 Yayati Jadhav , Amir Barati Farimani

Large language models (LLMs) are increasingly used to automate feature engineering in tabular learning. Given task-specific information, LLMs can propose diverse feature transformation operations to enhance downstream model performance.…

Machine Learning · Computer Science 2026-01-30 Zhuoyan Li , Aditya Bansal , Jinzhao Li , Shishuang He , Zhuoran Lu , Mutian Zhang , Qin Liu , Yiwei Yang , Swati Jain , Ming Yin , Yunyao Li

Large Language Models (LLMs) have demonstrated remarkable capabilities on various tasks, while the further evolvement is limited to the lack of high-quality training data. In addition, traditional training approaches rely too much on…

Computation and Language · Computer Science 2025-02-14 Peidong Wang , Ming Wang , Zhiming Ma , Xiaocui Yang , Shi Feng , Daling Wang , Yifei Zhang , Kaisong Song

Recent progress in large-scale CLIP-like vision-language models(VLMs) has greatly advanced medical image analysis. However, most existing medical VLMs still rely on coarse image-text contrastive objectives and fail to capture the systematic…

Computer Vision and Pattern Recognition · Computer Science 2026-02-09 Cheng Liang , Chaoyi Wu , Weike Zhao , Ya Zhang , Yanfeng Wang , Weidi Xie

This paper introduces PhyloLM, a method adapting phylogenetic algorithms to Large Language Models (LLMs) to explore whether and how they relate to each other and to predict their performance characteristics. Our method calculates a…

Computation and Language · Computer Science 2025-12-09 Nicolas Yax , Pierre-Yves Oudeyer , Stefano Palminteri