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Mental disorders represent a critical global health challenge, and social media is increasingly viewed as a vital resource for real-time digital phenotyping and intervention. To leverage this data, large language models (LLMs) have been…

Computation and Language · Computer Science 2025-12-23 Zhuohan Ge , Darian Li , Yubo Wang , Nicole Hu , Xinyi Zhu , Haoyang Li , Xin Zhang , Mingtao Zhang , Shihao Qi , Yuming Xu , Han Shi , Chen Jason Zhang , Qing Li

Automated depression diagnosis aims to analyze multimodal information from interview videos to predict participants' depression scores. Previous studies often lack clear explanations of how these scores were determined, limiting their…

Artificial Intelligence · Computer Science 2026-03-19 Wei Zhang , Juan Chen , En Zhu , Wenhong Cheng , YunPeng Li , Yanbo J. Wang

Alzheimer's Disease Analysis Model (ADAM) is a multi-agent reasoning large language model (LLM) framework designed to integrate and analyze multimodal data, including microbiome profiles, clinical datasets, and external knowledge bases, to…

Artificial Intelligence · Computer Science 2025-08-22 Ziyuan Huang , Vishaldeep Kaur Sekhon , Roozbeh Sadeghian , Maria L. Vaida , Cynthia Jo , Doyle Ward , Vanni Bucci , John P. Haran

Large Language Models have advanced clinical text classification, but their opaque predictions remain a critical barrier to practical adoption in research and clinical settings where investigators and physicians need to understand which…

Computation and Language · Computer Science 2025-11-18 Karthikeyan K , Raghuveer Thirukovalluru , David Carlson

Early detection of depression from social media data offers a valuable opportunity for timely intervention. However, this task poses significant challenges, requiring both professional medical knowledge and the development of accurate and…

Computation and Language · Computer Science 2025-03-20 Xiangyong Chen , Xiaochuan Lin

Compared to other clinical screening techniques, speech-and-language-based automated Alzheimer's disease (AD) detection methods are characterized by their non-invasiveness, cost-effectiveness, and convenience. Previous studies have…

Audio and Speech Processing · Electrical Eng. & Systems 2024-12-10 Yin-Long Liu , Rui Feng , Jia-Hong Yuan , Zhen-Hua Ling

Timely and accurate assessment of cognitive impairment remains a major unmet need. Speech biomarkers offer a scalable, non-invasive, cost-effective solution for automated screening. However, the clinical utility of machine learning (ML)…

Local Interpretable Model-Agnostic Explanations (LIME) is a popular technique used to increase the interpretability and explainability of black box Machine Learning (ML) algorithms. LIME typically generates an explanation for a single…

Machine Learning · Computer Science 2019-06-26 Muhammad Rehman Zafar , Naimul Mefraz Khan

Large language models (LLMs) are increasingly used in decision-making tasks like r\'esum\'e screening and content moderation, giving them the power to amplify or suppress certain perspectives. While previous research has identified…

Computation and Language · Computer Science 2025-05-28 Naba Rizvi , Harper Strickland , Saleha Ahmedi , Aekta Kallepalli , Isha Khirwadkar , William Wu , Imani N. S. Munyaka , Nedjma Ousidhoum

An important issue impacting healthcare is a lack of available experts. Machine learning (ML) models could resolve this by aiding in diagnosing patients. However, creating datasets large enough to train these models is expensive. We…

Computation and Language · Computer Science 2024-05-14 Chancellor R. Woolsey , Prakash Bisht , Joshua Rothman , Gondy Leroy

Effective patient-provider communication is crucial in clinical care, directly impacting patient outcomes and quality of life. Traditional evaluation methods, such as human ratings, patient feedback, and provider self-assessments, are often…

Computation and Language · Computer Science 2024-09-25 Zhiyuan Wang , Fangxu Yuan , Virginia LeBaron , Tabor Flickinger , Laura E. Barnes

Large language models (LLMs) not only exhibit human-like performance but also share computational principles with the brain's language processing mechanisms. While prior research has focused on mapping LLMs' internal representations to…

Computation and Language · Computer Science 2025-04-07 Maryam Rahimi , Yadollah Yaghoobzadeh , Mohammad Reza Daliri

Cognitive distortions have been closely linked to mental health disorders, yet their automatic detection remains challenging due to contextual ambiguity, co-occurrence, and semantic overlap. We propose a novel framework that combines Large…

Computation and Language · Computer Science 2026-04-20 Jun Seo Kim , Hyemi Kim , Woo Joo Oh , Hongjin Cho , Hochul Lee , Hye Hyeon Kim

Clinical Decision Support Systems (CDSS) utilize evidence-based knowledge and patient data to offer real-time recommendations, with Large Language Models (LLMs) emerging as a promising tool to generate plain-text explanations for medical…

Computation and Language · Computer Science 2023-10-04 D. Umerenkov , G. Zubkova , A. Nesterov

Depression is a growing concern gaining attention in both public discourse and AI research. While deep neural networks (DNNs) have been used for recognition, they still lack real-world effectiveness. Large language models (LLMs) show strong…

Human-Computer Interaction · Computer Science 2025-08-27 Yupei Li , Shuaijie Shao , Manuel Milling , Björn W. Schuller

The differential diagnosis of neurodegenerative dementias is a challenging clinical task, mainly because of the overlap in symptom presentation and the similarity of patterns observed in structural neuroimaging. To improve diagnostic…

Machine Learning · Computer Science 2025-05-27 Andrew Zamai , Nathanael Fijalkow , Boris Mansencal , Laurent Simon , Eloi Navet , Pierrick Coupe

Tabular data is often hidden in text, particularly in medical diagnostic reports. Traditional machine learning (ML) models designed to work with tabular data, cannot effectively process information in such form. On the other hand, large…

Machine Learning · Computer Science 2023-06-09 Aleksa Bisercic , Mladen Nikolic , Mihaela van der Schaar , Boris Delibasic , Pietro Lio , Andrija Petrovic

Detecting jailbreak attempts in clinical training large language models (LLMs) requires accurate modeling of linguistic deviations that signal unsafe or off-task user behavior. Prior work on the 2-Sigma clinical simulation platform showed…

Artificial Intelligence · Computer Science 2026-02-17 Tri Nguyen , Huy Hoang Bao Le , Lohith Srikanth Pentapalli , Laurah Turner , Kelly Cohen

This survey paper delves into the emerging and critical area of symbolic knowledge distillation in Large Language Models (LLMs). As LLMs like Generative Pre-trained Transformer-3 (GPT-3) and Bidirectional Encoder Representations from…

Computation and Language · Computer Science 2024-08-21 Kamal Acharya , Alvaro Velasquez , Houbing Herbert Song

There are two main barriers to using large language models (LLMs) in clinical reasoning. Firstly, while LLMs exhibit significant promise in Natural Language Processing (NLP) tasks, their performance in complex reasoning and planning falls…

Artificial Intelligence · Computer Science 2024-12-31 Shengxin Hong , Liang Xiao , Xin Zhang , Jianxia Chen