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In many adult tissues, stem cells and differentiated cells are not homogeneously distributed : stem cells are arranged in periodic "niches", and differentiated cells are constantly produced and migrate out of these niches. In this article,…

Biological Physics · Physics 2016-03-23 Edouard Hannezo , Alice Coucke , Jean-François Joanny

The dispersal of cells from an initially constrained location is a crucial aspect of many physiological phenomena ranging from morphogenesis to tumour spreading. In such processes, the way cell-cell interactions impact the motion of single…

The cohesive collective motion (flocking, swarming) of autonomous agents is ubiquitously observed and exploited in both natural and man-made settings, thus, minimal models for its description are essential. In a model with continuous space…

Statistical Mechanics · Physics 2015-01-12 Illes J. Farkas , Jeromos Kun , Yi Jin , Gaoqi He , Mingliang Xu

Spontaneous directed motion, a hallmark of cell biology, is unusual in classical statistical physics. Here we study, using both numerical and analytical methods, organized motion in models of the cytoskeleton in which constituents are…

Soft Condensed Matter · Physics 2012-05-31 Shenshen Wang , Peter G. Wolynes

These lecture notes are designed to provide a brief introduction into the phenomenology of active matter and to present some of the analytical tools used to rationalize the emergent behavior of active systems. Such systems are made of…

Soft Condensed Matter · Physics 2018-07-02 Étienne Fodor , M. Cristina Marchetti

Navigation of microorganisms is controlled by internal processes ultimately sensitive to mechanical or chemical signaling encountered along the path. In many natural environments, such as porous soils or physiological ducts, motile species…

A novel theory for cell differentiation is proposed, based on simulations with interacting artificial cells which have metabolic networks within, and divide into two when the final product is accumulated. Results of simulations with coupled…

adap-org · Physics 2015-06-30 Kunihiko Kaneko , Tetsuya Yomo

Low-dimensional, complex systems are often characterized by logarithmically slow dynamics. We study the generic motion of a labeled particle in an ensemble of identical diffusing particles with hardcore interactions in a strongly…

Movements of molecular motors on cytoskeletal filaments are described by directed walks on a line. Detachment from this line is allowed to occur with a small probability. Motion in the surrounding fluid is described by symmetric random…

Statistical Mechanics · Physics 2007-05-23 Theo M. Nieuwenhuizen , Stefan Klumpp , Reinhard Lipowsky

The behavior of active matter under confinement poses significant challenges due to the intricate coupling between dynamics near boundaries and those in the bulk. A defining feature of active matter systems is that a substantial portion of…

Analysis of PDEs · Mathematics 2025-08-25 Leonid Berlyand , Spencer Dang , Pierre-Emmanuel Jabin , Mykhailo Potomkin

Collective motion is ubiquitous in active systems at all length and time scales. The mechanisms behind such collective motion usually are alignment interactions between active particles, effective alignment after collisions between agents…

Soft Condensed Matter · Physics 2026-02-24 José Martín-Roca , Daniel Escobar Ortiz , Chantal Valeriani , Horacio Serna

Understanding the out-of-equilibrium properties of noisy microscale systems and the extent to which they can be modulated externally, is a crucial scientific and technological challenge. It holds the promise to unlock disruptive new…

Soft Condensed Matter · Physics 2022-09-21 Stephen Williams , Raphaël Jeanneret , Idan Tuval , Marco Polin

Heterogeneous systems of active matter exhibit a range of complex emergent dynamical patterns. In particular, it is difficult to predict the properties of the mixed system based on its constituents. These considerations are particularly…

Soft Condensed Matter · Physics 2021-04-07 Shlomit Peled , Shawn D. Ryan , Sebastian Heidenreich , Markus Bar , Gil Ariel , Avraham Be'er

Growth-fragmentation processes model systems of cells that grow continuously over time and then fragment into smaller pieces. Typically, on average, the number of cells in the system exhibits asynchronous exponential growth and, upon…

Probability · Mathematics 2023-06-08 Emma Horton , Alexander R. Watson

Inspired by motile cells in tissue formation, we find that active systems of self-aligning adhesive particles undergo ballistic aggregation through a flocking transition. This kinetic regime emerges when the cluster persistence length grows…

Behavior of the mixture of particles and dimers moving with different jump rates at reconstructed surfaces is described. Collective diffusion coefficient is calculated by the variational approach. Anisotropy of the collective particle…

Statistical Mechanics · Physics 2014-05-12 Marcin Mińkowski , Magdalena A. Załuska Kotur

Chemical reactions inside cells are generally considered to happen within fixed-size compartments. Needless to say, cells and their compartments are highly dynamic. Thus, such stringent assumptions may not reflect biochemical reality, and…

Quantitative Methods · Quantitative Biology 2016-02-17 Atiyo Ghosh , Tatiana T. Marquez-Lago

Bacterial colonies are a well-known example of living active matter, exhibiting collective behaviors such as nematic alignment and collective motion that play an important role in the spread of microbial infections. While the underlying…

A theoretical calculation is presented to describe the confined motion of transmembrane molecules in cell membranes. The study is analytic, based on Master equations for the probability of the molecules moving as random walkers, and leads…

Biological Physics · Physics 2009-11-13 V. M. Kenkre , L. Giuggioli , Z. Kalay

We theoretically study mixtures of chemically-interacting particles, which produce or consume a chemical to which they are attracted or repelled, in the most general case of many coexisting species. We find a new class of active phase…

Soft Condensed Matter · Physics 2019-07-15 Jaime Agudo-Canalejo , Ramin Golestanian