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Medical image anomaly detection faces unique challenges due to subtle, heterogeneous anomalies embedded in complex anatomical structures. Through systematic Grad-CAM analysis, we reveal that discriminative activation maps fail on medical…

Computer Vision and Pattern Recognition · Computer Science 2026-03-10 Xijun Lu , Hongying Liu , Fanhua Shang , Yanming Hui , Liang Wan

Distance-based methods involve the computation of distance values between features and are a well-established paradigm in machine learning. In anomaly detection, anomalies are identified by their large distance from normal data points.…

Instrumentation and Methods for Astrophysics · Physics 2025-10-29 Siddharth Chaini , Federica B. Bianco , Ashish Mahabal

Anomaly detection is the process of finding data points that deviate from a baseline. In a real-life setting, anomalies are usually unknown or extremely rare. Moreover, the detection must be accomplished in a timely manner or the risk of…

Machine Learning · Computer Science 2019-04-26 Mariem Ben Fadhel , Kofi Nyarko

Despite the recent improvements in overall accuracy, deep learning systems still exhibit low levels of robustness. Detecting possible failures is critical for a successful clinical integration of these systems, where each data point…

Image and Video Processing · Electrical Eng. & Systems 2019-10-14 Alain Jungo , Mauricio Reyes

Anomaly detection in tabular data remains challenging due to complex feature interactions and the scarcity of anomalous examples. Denoising autoencoders rely on fixed-magnitude noise, limiting adaptability to diverse data distributions.…

Machine Learning · Computer Science 2025-08-04 Timur Sattarov , Marco Schreyer , Damian Borth

Deep learning (DL) algorithms can be used to automate paranasal anomaly detection from Magnetic Resonance Imaging (MRI). However, previous works relied on supervised learning techniques to distinguish between normal and abnormal samples.…

Despite the remarkable performance of supervised medical image segmentation models, relying on a large amount of labeled data is impractical in real-world situations. Semi-supervised learning approaches aim to alleviate this challenge using…

Computer Vision and Pattern Recognition · Computer Science 2025-09-17 Yunyao Lu , Yihang Wu , Ahmad Chaddad , Tareef Daqqaq , Reem Kateb

Deep learning methods for unsupervised registration often rely on objectives that assume a uniform noise level across the spatial domain (e.g. mean-squared error loss), but noise distributions are often heteroscedastic and input-dependent…

Image and Video Processing · Electrical Eng. & Systems 2024-07-19 Xiaoran Zhang , Daniel H. Pak , Shawn S. Ahn , Xiaoxiao Li , Chenyu You , Lawrence H. Staib , Albert J. Sinusas , Alex Wong , James S. Duncan

Anomaly detection is to recognize samples that differ in some respect from the training observations. These samples which do not conform to the distribution of normal data are called outliers or anomalies. In real-world anomaly detection…

Computer Vision and Pattern Recognition · Computer Science 2022-07-05 Vahid Reza Khazaie , Anthony Wong , Yalda Mohsenzadeh

Security-sensitive applications that rely on Deep Neural Networks (DNNs) are vulnerable to small perturbations that are crafted to generate Adversarial Examples(AEs). The AEs are imperceptible to humans and cause DNN to misclassify them.…

Cryptography and Security · Computer Science 2021-06-22 Ahmed Aldahdooh , Wassim Hamidouche , Olivier Déforges

Unsupervised anomaly detection plays a pivotal role in industrial defect inspection and medical image analysis, with most methods relying on the reconstruction framework. However, these methods may suffer from over-generalization, enabling…

Computer Vision and Pattern Recognition · Computer Science 2026-03-25 Wei Luo , Peng Xing , Yunkang Cao , Haiming Yao , Weiming Shen , Zechao Li

Anomaly detection (AD) is a machine learning task that identifies anomalies by learning patterns from normal training data. In many real-world scenarios, anomalies vary in severity, from minor anomalies with little risk to severe…

Machine Learning · Computer Science 2024-11-25 Tri Cao , Minh-Huy Trinh , Ailin Deng , Quoc-Nam Nguyen , Khoa Duong , Ngai-Man Cheung , Bryan Hooi

Unsupervised learning can discover various unseen abnormalities, relying on large-scale unannotated medical images of healthy subjects. Towards this, unsupervised methods reconstruct a 2D/3D single medical image to detect outliers either in…

Computer Vision and Pattern Recognition · Computer Science 2020-10-13 Changhee Han , Leonardo Rundo , Kohei Murao , Tomoyuki Noguchi , Yuki Shimahara , Zoltan Adam Milacski , Saori Koshino , Evis Sala , Hideki Nakayama , Shinichi Satoh

The increasing complexity of medical imaging data underscores the need for advanced anomaly detection methods to automatically identify diverse pathologies. Current methods face challenges in capturing the broad spectrum of anomalies, often…

Image and Video Processing · Electrical Eng. & Systems 2024-01-22 Cosmin I. Bercea , Benedikt Wiestler , Daniel Rueckert , Julia A. Schnabel

We extend Deep Deterministic Uncertainty (DDU), a method for uncertainty estimation using feature space densities, to semantic segmentation. DDU enables quantifying and disentangling epistemic and aleatoric uncertainty in a single forward…

Computer Vision and Pattern Recognition · Computer Science 2021-11-02 Jishnu Mukhoti , Joost van Amersfoort , Philip H. S. Torr , Yarin Gal

The wide variety of in-distribution and out-of-distribution data in medical imaging makes universal anomaly detection a challenging task. Recently a number of self-supervised methods have been developed that train end-to-end models on…

Computer Vision and Pattern Recognition · Computer Science 2022-09-05 Matthew Baugh , Jeremy Tan , Athanasios Vlontzos , Johanna P. Müller , Bernhard Kainz

Anomaly detection (AD) plays a vital role across a wide range of real-world domains by identifying data instances that deviate from expected patterns, potentially signaling critical events such as system failures, fraudulent activities, or…

Machine Learning · Computer Science 2025-07-11 Amirhossein Sadough , Mahyar Shahsavari , Mark Wijtvliet , Marcel van Gerven

Pathological brain lesions exhibit diverse appearance in brain images, in terms of intensity, texture, shape, size, and location. Comprehensive sets of data and annotations are difficult to acquire. Therefore, unsupervised anomaly detection…

The issue of disagreements amongst human experts is a ubiquitous one in both machine learning and medicine. In medicine, this often corresponds to doctor disagreements on a patient diagnosis. In this work, we show that machine learning…

Machine Learning · Computer Science 2019-05-30 Maithra Raghu , Katy Blumer , Rory Sayres , Ziad Obermeyer , Robert Kleinberg , Sendhil Mullainathan , Jon Kleinberg

Unknown anomaly detection in medical imaging remains a fundamental challenge due to the scarcity of labeled anomalies and the high cost of expert supervision. We introduce an unsupervised, oracle-free framework that incrementally expands a…

Computer Vision and Pattern Recognition · Computer Science 2025-11-12 Nand Kumar Yadav , Rodrigue Rizk , William CW Chen , KC Santosh