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Purpose: The segmentation of brain tumors is one of the most active areas of medical image analysis. While current methods perform superhuman on benchmark data sets, their applicability in daily clinical practice has not been evaluated. In…
Pancreatic ductal adenocarcinoma (PDAC) presents a critical global health challenge, and early detection is crucial for improving the 5-year survival rate. Recent medical imaging and computational algorithm advances offer potential…
Skin cancer is one of the most threatening diseases worldwide. However, diagnosing skin cancer correctly is challenging. Recently, deep learning algorithms have emerged to achieve excellent performance on various tasks. Particularly, they…
Computer-Aided Diagnosis and Treatment of Tumors is a hot topic of deep learning in recent years, which constitutes a series of medical tasks, such as detection of tumor markers, the outline of tumor leisures, subtypes and stages of tumors,…
While artificial intelligence (AI) algorithms continue to rival human performance on a variety of clinical tasks, the question of how best to incorporate these algorithms into clinical workflows remains relatively unexplored. We…
Risk stratification (characterization) of tumors from radiology images can be more accurate and faster with computer-aided diagnosis (CAD) tools. Tumor characterization through such tools can also enable non-invasive cancer staging,…
For deep learning applications, the massive data development (e.g., collecting, labeling), which is an essential process in building practical applications, still incurs seriously high costs. In this work, we propose an effective data…
The generalization capability of machine learning models, which refers to generalizing the knowledge for an "unseen" domain via learning from one or multiple seen domain(s), is of great importance to develop and deploy machine learning…
Despite great advances, molecular cancer pathology is often limited to the use of a small number of biomarkers rather than the whole transcriptome, partly due to computational challenges. Here, we introduce a novel architecture of Deep…
The domain shift between training and testing data presents a significant challenge for training generalizable deep learning models. As a consequence, the performance of models trained with the independent and identically distributed…
Domain Generalization (DG) aims to learn models whose performance remains high on unseen domains encountered at test-time by using data from multiple related source domains. Many existing DG algorithms reduce the divergence between source…
The process of digitising histology slides involves multiple factors that can affect a whole slide image's (WSI) final appearance, including the staining protocol, scanner, and tissue type. This variability constitutes a domain shift and…
Recent advances in deep learning for medical image segmentation demonstrate expert-level accuracy. However, in clinically realistic environments, such methods have marginal performance due to differences in image domains, including…
Remarkable strides in computational pathology have been made in the task-agnostic foundation model that advances the performance of a wide array of downstream clinical tasks. Despite the promising performance, there are still several…
We tackle the challenging problem of single-source domain generalization (DG) for medical image segmentation, where we train a network on one domain (e.g., CT) and directly apply it to a different domain (e.g., MR) without adapting the…
Foundation models for computational pathology are expected to facilitate the development of high-performing, generalisable deep learning systems. However, in addition to biologically relevant features, current foundation models also capture…
Supervised deep learning models often achieve excellent performance within their training distribution but struggle to generalize beyond it. In cancer histopathology, for example, a convolutional neural network (CNN) may classify cancer…
Histopathology images; microscopy images of stained tissue biopsies contain fundamental prognostic information that forms the foundation of pathological analysis and diagnostic medicine. However, diagnostics from histopathology images…
Accurate skin cancer diagnosis is vital for early treatment and improved patient outcomes. Deep learning (DL) models have shown promise in automating skin cancer classification, yet challenges remain due to data scarcity and limited…
This study addresses critical gaps in automated lymphoma segmentation from PET/CT images, focusing on issues often overlooked in existing literature. While deep learning has been applied for lymphoma lesion segmentation, few studies…