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A series of simulations aimed at elucidating the self-assembly dynamics of spherical virus capsids is described. This little-understood phenomenon is a fascinating example of the complex processes that occur in the simplest of organisms.…

Soft Condensed Matter · Physics 2015-05-19 D. C. Rapaport

We study the evolution of dynamic fluctuations averaged over different space lengths and time scales to characterize spatially and temporally heterogeneous behavior of TIP4P/2005 water in liquid and supercooled states. Analysing a million…

Spontaneous phase separation, or demixing, is important in biological phenomena such as cell sorting. In particle-based models, an open question is whether differences in diffusivity can drive such demixing. While…

Soft Condensed Matter · Physics 2023-07-10 Erin McCarthy , Ojan Damavandi , Raj Kumar Manna , M. Lisa Manning

The spatial structure of the cell is highly organized at all levels: from small complexes and assemblies, to local nano- and micro-clusters, to global, micrometer scales across and between cells. We suggest that this multiscale spatial cell…

Biomolecules · Quantitative Biology 2013-08-06 Ruth Nussinov

Growth-fragmentation processes describe the evolution of systems of cells which grow continuously and fragment suddenly; they are used in models of cell division and protein polymerisation. Typically, we may expect that in the long run, the…

Probability · Mathematics 2021-01-22 Jean Bertoin , Alexander Watson

A brief review of our recent studies aiming at a better understanding of the scaling behaviour of polymers in disordered environments is given. The main emphasis is on a simple generic model where the polymers are represented by…

Soft Condensed Matter · Physics 2014-11-19 V. Blavatska , N. Fricke , W. Janke

Tissue self-organization into defined and well-controlled three-dimensional structures is essential during development for the generation of organs. A similar, but highly deranged process might also occur during the aberrant growth of…

Cell Behavior · Quantitative Biology 2019-05-21 Abramo Agosti , Stefano Marchesi , Giorgio Scita , Pasquale Ciarletta

We introduce a model for describing the defected growth of striped patterns. This model, while roughly related to the Swift-Hohenberg model, generates a quite different mixture of defects during phase ordering. We find two characteristic…

Soft Condensed Matter · Physics 2009-11-10 Hai Qian , Gene F. Mazenko

We demonstrate particle clustering on macroscopic scales in a coupled nonequilibrium system where two species of particles are advected by a fluctuating landscape and modify the landscape in the process. The phase diagram generated by…

Statistical Mechanics · Physics 2016-05-24 Shauri Chakraborty , Sukla Pal , Sakuntala Chatterjee , Mustansir Barma

The spatial organization of bacteria in dense biofilms is key to their collective behaviour, and understanding it will be important for medical and technological applications. Here we study the morphology of a compact biofilm that undergoes…

Biological Physics · Physics 2019-03-05 Xin Wang , Howard A. Stone , Ramin Golestanian

Lateral diffusion of molecules on surfaces plays a very important role in various biological processes, including lipid transport across the cell membrane, synaptic transmission and other phenomena such as exo- and endocytosis, signal…

Analysis of PDEs · Mathematics 2013-11-12 A. B. Duncan , C. M. Elliott , G. A. Pavliotis , A. M. Stuart

We continue to study a model of disordered interface growth in two dimensions. The interface is given by a height function on the sites of the one--dimensional integer lattice and grows in discrete time: (1) the height above the site $x$…

Probability · Mathematics 2007-05-23 Janko Gravner , Craig A. Tracy , Harold Widom

Diffusion processes are widespread in biological and chemical systems, where they play a fundamental role in the exchange of substances at the cellular level and in determining the rate of chemical reactions. Recently, the classical picture…

Soft Condensed Matter · Physics 2015-09-16 Roberto Cerbino , Yifei Sun , Aleksandar Donev , Alberto Vailati

When an ensemble of particles interact hydrodynamically, they generically display large-scale transient structures such as swirls in sedimenting particles [1], or colloidal strings in sheared suspensions [2]. Understanding these…

Soft Condensed Matter · Physics 2013-01-24 Nicolas Desreumaux , Jean-Baptiste Caussin , Raphael Jeanneret , Eric Lauga , Denis Bartolo

We discuss shape profiles emerging in inhomogeneous growth of squeezed tissues. Two approaches are used simultaneously: i) conformal embedding of two-dimensional domain with hyperbolic metrics into the plane, and ii) a pure energetic…

Soft Condensed Matter · Physics 2015-11-25 Sergei Nechaev , Kirill Polovnikov

Spatially annotated single-cell datasets provide unprecedented opportunities to dissect cell-cell communication in development and disease. Heterotypic signaling includes interactions between different cell types and is well established in…

Genomics · Quantitative Biology 2023-03-03 Fabian V. Filipp

A recent experiment on zebrafish blastoderm morphogenesis showed that the viscosity ({\eta}) of a non-confluent embryonic tissue grows sharply until a critical cell packing fraction ({\phi}S). The increase in {\eta} up to {\phi}S is similar…

Soft Condensed Matter · Physics 2023-11-28 Rajsekhar Das , Sumit Sinha , Xin Li , T. R. Kirkpatrick , D. Thirumalai

Here we show that coupling to curvature has profound effects on collective motion in active systems, leading to patterns not observed in flat space. Biological examples of such active motion in curved environments are numerous: curvature…

Soft Condensed Matter · Physics 2015-03-05 Rastko Sknepnek , Silke Henkes

We consider a system of interacting diffusions labeled by a geographic space that is given by the hierarchical group $\Omega_N$ of order $N\in\mathbb{N}$. Individuals live in colonies and are subject to resampling and migration as long as…

Probability · Mathematics 2021-10-07 Andreas Greven , Frank den Hollander , Margriet Oomen

Groups of animals often tend to arrange themselves in flocks that have characteristic spatial attributes and temporal dynamics. Using a dynamic continuum model for a flock of individuals, we find equilibria of finite spatial extent where…

Adaptation and Self-Organizing Systems · Physics 2012-01-16 Nicholas A. Mecholsky , Edward Ott , Thomas M. Antonsen , Parvez Guzdar