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Exposure to laser light alters cell culture examination via optical microscopic imaging techniques, also based on label-free coherent digital holography. To mitigate this detrimental feature, researchers tend to use a broader spectrum and…

Quantitative phase imaging (QPI) quantifies the sample-specific optical-phase-delay enabling objective studies of optically-transparent specimens such as biological samples, but lacks chemical sensitivity limiting its application to…

Optics · Physics 2019-09-04 Miu Tamamitsu , Keiichiro Toda , Ryoichi Horisaki , Takuro Ideguchi

Large field-of-view (FOV) microscopic imaging with high lateral resolution (1-2 microns for high space-bandwidth product) plays a pivotal role in biomedicine and biophotonics, especially within the label-free regime, e.g., for whole slide…

Quantitative phase imaging (QPI) enables label-free, high-contrast visualization of transparent specimens, but its common implementation in off-axis digital holographic microscopy (DHM) requires a separate reference beam, which increases…

Quantitative phase imaging (QPI) is a label-free computational imaging technique used in various fields, including biology and medical research. Modern QPI systems typically rely on digital processing using iterative algorithms for phase…

Optics · Physics 2023-06-28 Yuhang Li , Yi Luo , Deniz Mengu , Bijie Bai , Aydogan Ozcan

Quantitative phase imaging (QPI) enables visualization and quantitative extraction of the optical phase information of transparent samples. However, conventional QPI techniques typically rely on multi-frame acquisition or complex…

Quantitative phase imaging (QPI) has been widely applied in characterizing cells and tissues. Spatial light interference microscopy (SLIM) is a highly sensitive QPI method, due to its partially coherent illumination and common path…

Image and Video Processing · Electrical Eng. & Systems 2024-06-12 Yuheng Jiao , Yuchen R. He , Mikhail E. Kandel , Xiaojun Liu , Wenlong Lu , Gabriel Popescu

Label-free imaging approaches seek to simplify and augment histopathologic assessment by replacing the current practice of staining by dyes to visualize tissue morphology with quantitative optical measurements. Quantitative phase imaging…

This paper reported a general noninterferometric high-accuracy quantitative phase imaging (QPI) method for arbitrary complex valued objects. Given by a typical 4f optical configuration as the imaging system, three frames of small-window…

Image and Video Processing · Electrical Eng. & Systems 2021-05-05 Jianhui Huang , An Pan , Huiliang Jin , Guoxiang Meng , Qian Ye

Large Multimodal Models (LMMs) have recently shown remarkable promise in low-level visual perception tasks, particularly in Image Quality Assessment (IQA), demonstrating strong zero-shot capability. However, achieving state-of-the-art…

Computer Vision and Pattern Recognition · Computer Science 2026-01-14 Kang Fu , Huiyu Duan , Zicheng Zhang , Yucheng Zhu , Jun Zhao , Xiongkuo Min , Jia Wang , Guangtao Zhai

Lensless digital holographic microscopy (LDHM) offers very large field-of-view label-free imaging crucial, e.g., in high-throughput particle tracking and biomedical examination of cells and tissues. Compact layouts promote point-of-case and…

Optics · Physics 2023-10-24 Piotr Arcab , Mikolaj Rogalski , Maciej Trusiak

Quantitative phase imaging (QPI) is a valuable label-free modality that has gained significant interest due to its wide potentials, from basic biology to clinical applications. Most existing QPI systems measure microscopic objects via…

Optics · Physics 2021-12-22 Chenfei Hu , Mikhail E. Kandel , Young Jae Lee , Gabriel Popescu

Digital holographic microscopy (DHM) applied to quantitative phase imaging (QPI) has been successfully demonstrated as a powerful label-free method to analyse the optical properties of cells. Spatially multiplexed interferometric microscopy…

Binary amplitude spatial light modulators, such as digital micromirror devices (DMDs), are increasingly relevant for computer generated holography due to their high refresh rates, low cost, and due to the emergence of subwavelength pixel…

We present a data-driven approach to compensate for optical aberration in calibration-free quantitative phase imaging (QPI). Unlike existing methods that require additional measurements or a background region to correct aberrations, we…

Image and Video Processing · Electrical Eng. & Systems 2020-12-02 Taean Chang , Youngju Jo , Gunho Choi , Donghun Ryu , Hyun-Seok Min , Yongkeun Park

Coherent Diffractive Imaging is a lensless technique that allows imaging of matter at a spatial resolution not limited by lens aberrations. This technique exploits the measured diffraction pattern of a coherent beam scattered by periodic…

Computational Physics · Physics 2025-08-27 Alessandro Colombo , Davide Emilio Galli , Liberato De Caro , Francesco Scattarella , Elvio Carlino

In certain applications or wavelength regimes, essential optical components for imaging systems are either unavailable or challenging to fabricate. To address this, we propose an optics-free classical ghost imaging (GI) scheme utilizing…

Optics · Physics 2026-03-09 Yuhan Guo , Xiangyu Yin , Chunguang Meng , Liming Li , Huiqiang Liu

In this paper, a novel and effective image quality assessment (IQA) algorithm based on frequency disparity for high dynamic range (HDR) images is proposed, termed as local-global frequency feature-based model (LGFM). Motivated by the…

Computer Vision and Pattern Recognition · Computer Science 2022-09-07 Yue Liu , Zhangkai Ni , Shiqi Wang , Hanli Wang , Sam Kwong

Our goal is to reconstruct tomographic images with few measurements and a low signal-to-noise ratio. In clinical imaging, this helps to improve patient comfort and reduce radiation exposure. As quantum computing advances, we propose to use…

Quantum Physics · Physics 2023-10-17 Merlin A. Nau , A. Hans Vija , Wesley Gohn , Maximilian P. Reymann , Andreas K. Maier

Image quality assessment (IQA) is the key factor for the fast development of image restoration (IR) algorithms. The most recent perceptual IR algorithms based on generative adversarial networks (GANs) have brought in significant improvement…

Image and Video Processing · Electrical Eng. & Systems 2020-12-01 Jinjin Gu , Haoming Cai , Haoyu Chen , Xiaoxing Ye , Jimmy Ren , Chao Dong
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