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In a mathematical model of interacting biological organisms, where external interventions may alter behavior over time, traditional models that assume fixed parameters usually do not capture the evolving dynamics. In oncology, this is…

Machine Learning · Computer Science 2025-12-18 Kayode Olumoyin , Lamees El Naqa , Katarzyna Rejniak

The utilization of Deep Neural Networks (DNNs) in physical science and engineering applications has gained traction due to their capacity to learn intricate functions. While large datasets are crucial for training DNN models in fields like…

Machine Learning · Computer Science 2025-08-05 Vamsi Sai Krishna Malineni , Suresh Rajendran

The prohibitive cost and low fidelity of experimental data in industry scale thermofluid systems limit the usefulness of pure data-driven machine learning methods. Physics-informed neural networks (PINN) strive to overcome this by embedding…

Fluid Dynamics · Physics 2021-05-25 Ryno Laubscher , Pieter Rousseau

Complex physical systems are often described by partial differential equations (PDEs) that depend on parameters such as the Reynolds number in fluid mechanics. In applications such as design optimization or uncertainty quantification,…

Machine Learning · Computer Science 2024-08-20 Woojin Cho , Minju Jo , Haksoo Lim , Kookjin Lee , Dongeun Lee , Sanghyun Hong , Noseong Park

In chemical engineering, process data are expensive to acquire, and complex phenomena are difficult to fully model. We explore the use of physics-informed neural networks (PINNs) for modeling dynamic processes with incomplete mechanistic…

Machine Learning · Computer Science 2024-10-01 Mehmet Velioglu , Song Zhai , Sophia Rupprecht , Alexander Mitsos , Andreas Jupke , Manuel Dahmen

Parameter estimation remains a challenging task across many areas of engineering. Because data acquisition can often be costly, limited, or prone to inaccuracies (noise, uncertainty) it is crucial to identify sensor configurations that…

Machine Learning · Statistics 2025-11-20 Georgios Venianakis , Constantinos Theodoropoulos , Michail Kavousanakis

Physics-informed neural networks (PINNs) are revolutionizing science and engineering practice by bringing together the power of deep learning to bear on scientific computation. In forward modeling problems, PINNs are meshless partial…

Machine Learning · Computer Science 2023-11-28 Yicheng Wang , Xiaotian Han , Chia-Yuan Chang , Daochen Zha , Ulisses Braga-Neto , Xia Hu

Physics-informed neural networks (PINNs) have emerged as a powerful tool for solving inverse problems, especially in cases where no complete information about the system is known and scatter measurements are available. This is especially…

Computational Engineering, Finance, and Science · Computer Science 2023-08-03 Jeremias Garay , Jocelyn Dunstan , Sergio Uribe , Francisco Sahli Costabal

Physics-informed neural networks (PINNs) are a powerful approach for solving problems involving differential equations, yet they often struggle to solve problems with high frequency and/or multi-scale solutions. Finite basis…

Numerical Analysis · Mathematics 2024-06-21 Victorita Dolean , Alexander Heinlein , Siddhartha Mishra , Ben Moseley

Compartment models of cell culture are widely used in cytology, pharmacology, toxicology and other fields. Numerical simulation, data modeling and prediction of compartment models can be realized by traditional differential equation…

Quantitative Methods · Quantitative Biology 2022-06-13 Jiahao Ma

Physics-informed neural networks (PINNs), rooted in deep learning, have emerged as a promising approach for solving partial differential equations (PDEs). By embedding the physical information described by PDEs into feedforward neural…

Machine Learning · Computer Science 2024-01-26 Yanzhi Liu , Ruifan Wu , Ying Jiang

Physics-informed neural networks (PINNs) as a means of discretizing partial differential equations (PDEs) are garnering much attention in the Computational Science and Engineering (CS&E) world. At least two challenges exist for PINNs at…

Computational Physics · Physics 2023-01-23 Michael Penwarden , Shandian Zhe , Akil Narayan , Robert M. Kirby

Physics-informed neural network (PINN) is a powerful emerging method for studying forward-inverse problems of partial differential equations (PDEs), even from limited sample data. Variable coefficient PDEs, which model real-world phenomena,…

Computational Physics · Physics 2025-03-07 Hui-Juan Zhou , Yong Chen

In this work, we study physics-informed neural networks (PINNs) constrained by partial differential equations (PDEs) and their application in approximating PDEs with two characteristic scales. From a continuous perspective, our formulation…

Optimization and Control · Mathematics 2024-09-06 Michael Hintermüller , Denis Korolev

We propose to explore the potential of physics-informed neural networks (PINNs) in solving a class of partial differential equations (PDEs) used to model the propagation of chronic inflammatory bowel diseases, such as Crohn's disease and…

When investigating epidemic dynamics through differential models, the parameters needed to understand the phenomenon and to simulate forecast scenarios require a delicate calibration phase, often made even more challenging by the scarcity…

Numerical Analysis · Mathematics 2023-09-11 Giulia Bertaglia , Chuan Lu , Lorenzo Pareschi , Xueyu Zhu

Physics-informed neural networks (PINNs) have emerged as promising surrogate modes for solving partial differential equations (PDEs). Their effectiveness lies in the ability to capture solution-related features through neural networks.…

Machine Learning · Computer Science 2023-07-13 Junjun Yan , Xinhai Chen , Zhichao Wang , Enqiang Zhou , Jie Liu

Physics-Informed Neural Networks present a novel approach in SciML that integrates physical laws in the form of partial differential equations directly into the NN through soft constraints in the loss function. This work studies the…

Neural and Evolutionary Computing · Computer Science 2026-02-17 Suhas Suresh Bharadwaj , Reuben Thomas Thovelil

The application of deep learning methods to speed up the resolution of challenging power flow problems has recently shown very encouraging results. However, power system dynamics are not snap-shot, steady-state operations. These dynamics…

Machine Learning · Computer Science 2022-06-22 Mostafa Mohammadian , Kyri Baker , Ferdinando Fioretto

Physics-informed neural networks (PINNs) are an influential method of solving differential equations and estimating their parameters given data. However, since they make use of neural networks, they provide only a point estimate of…

Machine Learning · Computer Science 2024-05-15 Lena Podina , Mahdi Torabi Rad , Mohammad Kohandel
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