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Purpose: Trochlear Dysplasia (TD) is a common malformation in adolescents, leading to anterior knee pain and instability. Surgical interventions such as trochleoplasty require precise planning to correct the trochlear groove. However, no…

Image and Video Processing · Electrical Eng. & Systems 2024-12-16 Michael Wehrli , Alicia Durrer , Paul Friedrich , Volodimir Buchakchiyskiy , Marcus Mumme , Edwin Li , Gyozo Lehoczky , Carol C. Hasler , Philippe C. Cattin

Accurate morphometric assessment of cartilage-such as thickness/volume-via MRI is essential for monitoring knee osteoarthritis. Segmenting cartilage remains challenging and dependent on extensive expert-annotated datasets, which are heavily…

Image and Video Processing · Electrical Eng. & Systems 2026-02-24 Danielle L. Ferreira , Bruno A. A. Nunes , Xuzhe Zhang , Laura Carretero Gomez , Maggie Fung , Ravi Soni

Purpose: The purpose of our study was to use Dual-TR STE-MR protocol as a clinical tool for cortical bone free water quantification at 1.5T and validate it by comparing the obtained results (MR-derived results) with dehydration results.…

The diagnostic accuracy and subjectivity of existing Knee Osteoarthritis (OA) ordinal grading systems has been a subject of on-going debate and concern. Existing automated solutions are trained to emulate these imperfect systems, whilst…

Machine Learning · Computer Science 2025-05-30 Niamh Belton , Aonghus Lawlor , Kathleen M. Curran

In medical image analysis, automated segmentation of multi-component anatomical structures, which often have a spectrum of potential anomalies and pathologies, is a challenging task. In this work, we develop a multi-step approach using…

Image and Video Processing · Electrical Eng. & Systems 2022-12-02 Boyeong Woo , Craig Engstrom , William Baresic , Jurgen Fripp , Stuart Crozier , Shekhar S. Chandra

Magnetic Resonance Imaging (MRI) is the primary imaging modality used in the diagnosis, assessment, and treatment planning for brain pathologies. However, most automated MRI analysis tools, such as segmentation and registration pipelines,…

Quantitative MRI is highly desirable in terms of intrinsic tissue parameters such as T1, T2 and proton density. This approach promises to minimize diagnostic variability and differentiate normal and pathological tissues by comparing tissue…

Medical Physics · Physics 2018-06-21 Qing Lyu , Ge Wang

Scanner drift is a well-known magnetic resonance imaging (MRI) artifact characterized by gradual signal degradation and scan intensity changes over time. In addition, hardware and software updates may imply abrupt changes in signal. The…

Computer Vision and Pattern Recognition · Computer Science 2017-12-25 Erik B Dam

There has been significant progress in machine learning algorithms for human pose estimation that may provide immense value in rehabilitation and movement sciences. However, there remain several challenges to routine use of these tools for…

Computer Vision and Pattern Recognition · Computer Science 2022-03-17 R. James Cotton

In this work it is proposed a medical image segmentation pipeline for accurate bone segmentation from CT imaging. It is a two-step methodology, with a pre-segmentation step and a segmentation refinement step. First, the user performs a…

Medical Physics · Physics 2015-05-13 Manuel Pinheiro , J. L. Alves

Simulation of post-prandial pharmacokinetics, such as muscle protein synthesis (MPS) through mTORC1 and insulin-induced glucose uptake, is often challenging due to the computational intensity of the multi-compartmental approach. In this…

Other Quantitative Biology · Quantitative Biology 2026-05-28 Alberto Calderone

Magnetic resonance (MR) imaging is essential for evaluating central nervous system (CNS) tumors, guiding surgical planning, treatment decisions, and assessing postoperative outcomes and complication risks. While recent work has advanced…

Osteoarthritis is a degenerative condition affecting bones and cartilage, often leading to osteophyte formation, bone density loss, and joint space narrowing. Treatment options to restore normal joint function vary depending on the severity…

Image and Video Processing · Electrical Eng. & Systems 2024-10-17 Luca Marsilio , Davide Marzorati , Matteo Rossi , Andrea Moglia , Luca Mainardi , Alfonso Manzotti , Pietro Cerveri

The burgeoning complexity and scale of 3D geometry models pose significant challenges for deployment on resource-constrained platforms. While Post-Training Quantization (PTQ) enables efficient inference without retraining, conventional…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Sicheng Pan , Chen Tang , Shuzhao Xie , Ke Yang , Weixiang Zhang , Jiawei Li , Bin Chen , Shu-Tao Xia , Zhi Wang

Skeletonization extracts thin representations from images that compactly encode their geometry and topology. These representations have become an important topological prior for preserving connectivity in curvilinear structures, aiding…

Image and Video Processing · Electrical Eng. & Systems 2025-03-11 Luis D. Reyes Vargas , Martin J. Menten , Johannes C. Paetzold , Nassir Navab , Mohammad Farid Azampour

Precise segmentation of knee tissues from magnetic resonance imaging (MRI) is critical in quantitative imaging and diagnosis. Convolutional neural networks (CNNs), which are state of the art, have limitations owing to the lack of…

Image and Video Processing · Electrical Eng. & Systems 2021-09-30 Sheheryar Khan , Basim Azam , Yongcheng Yao , Weitian Chen

Timely and adequate rehabilitation is critical in facilitating post-stroke recovery. However, the organization and delivery of rehabilitation are resource-demanding, and are only available to approximately 25% of stroke survivors in…

Human-Computer Interaction · Computer Science 2024-02-13 Elton H. L. Yeung , Yingxian Chen , Wilton W. T. Fok , Gary K. K. Lau

$\textbf{Purpose}$: Automatic quantification of longitudinal changes in PET scans for lymphoma patients has proven challenging, as residual disease in interim-therapy scans is often subtle and difficult to detect. Our goal was to develop a…

Purpose: Automatic methods are required for the early detection of hepatic steatosis to avoid progression to cirrhosis and cancer. Here, we developed a fully automated deep learning pipeline to quantify hepatic steatosis on non-contrast…

Quantitative Methods · Quantitative Biology 2022-02-08 Zhongyi Zhang , Jakob Weiss , Jana Taron , Roman Zeleznik , Michael T. Lu , Hugo J. W. L. Aerts