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Related papers: ADIOS: Antibody Development via Opponent Shaping

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Based on a recent model of evolving viruses competing with an adapting immune system [1], we study the conditions under which a viral quasispecies can maximize its growth rate. The range of mutation rates that allows viruses to thrive is…

Statistical Mechanics · Physics 2007-05-23 Christel Kamp , Claus O. Wilke , Christoph Adami , Stefan Bornholdt

Therapeutic antibody candidates often require extensive engineering to improve key functional and developability properties before clinical development. This can be achieved through iterative design, where starting molecules are optimized…

Machine Learning · Computer Science 2025-09-23 Aniruddh Raghu , Sebastian Ober , Maxwell Kazman , Hunter Elliott

Antibody design is an essential yet challenging task in various domains like therapeutics and biology. There are two major defects in current learning-based methods: 1) tackling only a certain subtask of the whole antibody design pipeline,…

Biomolecules · Quantitative Biology 2023-05-31 Xiangzhe Kong , Wenbing Huang , Yang Liu

Rapid progress is being made in developing large, pretrained, task-agnostic foundational vision models such as CLIP, ALIGN, DINOv2, etc. In fact, we are approaching the point where these models do not have to be finetuned downstream, and…

Computer Vision and Pattern Recognition · Computer Science 2023-08-29 Nathan Inkawhich , Gwendolyn McDonald , Ryan Luley

Adversarial attacks in visual object tracking have significantly degraded the performance of advanced trackers by introducing imperceptible perturbations into images. However, there is still a lack of research on designing adversarial…

Computer Vision and Pattern Recognition · Computer Science 2024-08-06 Zhewei Wu , Ruilong Yu , Qihe Liu , Shuying Cheng , Shilin Qiu , Shijie Zhou

Autonomous vehicles are typical complex intelligent systems with artificial intelligence at their core. However, perception methods based on deep learning are extremely vulnerable to adversarial samples, resulting in security accidents. How…

Computer Vision and Pattern Recognition · Computer Science 2025-09-12 Yuanhao Huang , Yilong Ren , Jinlei Wang , Lujia Huo , Xuesong Bai , Jinchuan Zhang , Haiyan Yu

Adversarial training aims to defend against adversaries: malicious opponents whose sole aim is to harm predictive performance in any way possible. This presents a rather harsh perspective, which we assert results in unnecessarily…

Machine Learning · Computer Science 2025-06-10 Maayan Ehrenberg , Roy Ganz , Nir Rosenfeld

Unsupervised Domain Adaptation (UDA) is a key issue in visual recognition, as it allows to bridge different visual domains enabling robust performances in the real world. To date, all proposed approaches rely on human expertise to manually…

Computer Vision and Pattern Recognition · Computer Science 2021-10-25 Luca Robbiano , Muhammad Rameez Ur Rahman , Fabio Galasso , Barbara Caputo , Fabio Maria Carlucci

The security of object detection systems has attracted increasing attention, especially when facing adversarial patch attacks. Since patch attacks change the pixels in a restricted area on objects, they are easy to implement in the physical…

Computer Vision and Pattern Recognition · Computer Science 2021-03-17 Nan Ji , YanFei Feng , Haidong Xie , Xueshuang Xiang , Naijin Liu

The phenomenon of adversarial examples illustrates one of the most basic vulnerabilities of deep neural networks. Among the variety of techniques introduced to surmount this inherent weakness, adversarial training has emerged as the most…

Machine Learning · Computer Science 2022-09-14 Matan Levi , Idan Attias , Aryeh Kontorovich

Adversarial training and adversarial purification are two widely used defense strategies for enhancing model robustness against adversarial attacks. However, adversarial training requires costly retraining, while adversarial purification…

Computer Vision and Pattern Recognition · Computer Science 2025-09-17 Xuelong Dai , Dong Wang , Xiuzhen Cheng , Bin Xiao

Effective property prediction methods can help accelerate the search for COVID-19 antivirals either through accurate in-silico screens or by effectively guiding on-going at-scale experimental efforts. However, existing prediction tools have…

Quantitative Methods · Quantitative Biology 2020-05-08 Wengong Jin , Regina Barzilay , Tommi Jaakkola

Adversarial attacks, wherein slight inputs are carefully crafted to mislead intelligent models, have attracted increasing attention. However, a critical gap persists between theoretical advancements and practical application, particularly…

Cryptography and Security · Computer Science 2025-06-26 Sabrine Ennaji , Elhadj Benkhelifa , Luigi V. Mancini

Deep learning models, even the-state-of-the-art ones, are highly vulnerable to adversarial examples. Adversarial training is one of the most efficient methods to improve the model's robustness. The key factor for the success of adversarial…

Machine Learning · Computer Science 2023-06-05 Anh Bui , Trung Le , He Zhao , Quan Tran , Paul Montague , Dinh Phung

Vision-language pre-training (VLP) models exhibit remarkable capabilities in comprehending both images and text, yet they remain susceptible to multimodal adversarial examples (AEs). Strengthening attacks and uncovering vulnerabilities,…

Computer Vision and Pattern Recognition · Computer Science 2024-07-16 Sensen Gao , Xiaojun Jia , Xuhong Ren , Ivor Tsang , Qing Guo

Deep learning models are known to be vulnerable to adversarial attacks by injecting sophisticated designed perturbations to input data. Training-time defenses still exhibit a significant performance gap between natural accuracy and robust…

Machine Learning · Computer Science 2025-05-20 Cheng-Han Yeh , Kuanchun Yu , Chun-Shien Lu

The development of therapeutic antibodies heavily relies on accurate predictions of how antigens will interact with antibodies. Existing computational methods in antibody design often overlook crucial conformational changes that antigens…

Quantitative Methods · Quantitative Biology 2025-03-05 Cheng Tan , Yijie Zhang , Zhangyang Gao , Yufei Huang , Haitao Lin , Lirong Wu , Fandi Wu , Mathieu Blanchette , Stan. Z. Li

While adversarial training and its variants have shown to be the most effective algorithms to defend against adversarial attacks, their extremely slow training process makes it hard to scale to large datasets like ImageNet. The key idea of…

Machine Learning · Computer Science 2022-06-07 Zhichao Huang , Yanbo Fan , Chen Liu , Weizhong Zhang , Yong Zhang , Mathieu Salzmann , Sabine Süsstrunk , Jue Wang

Adversarial attacks pose significant challenges in 3D object recognition, especially in scenarios involving multi-view analysis where objects can be observed from varying angles. This paper introduces View-Invariant Adversarial…

Computer Vision and Pattern Recognition · Computer Science 2024-12-19 Christian Green , Mehmet Ergezer , Abdurrahman Zeybey

Adversarial purification is a kind of defense technique that can defend against various unseen adversarial attacks without modifying the victim classifier. Existing methods often depend on external generative models or cooperation between…

Computer Vision and Pattern Recognition · Computer Science 2025-05-28 Erhu Liu , Zonglin Yang , Bo Liu , Bin Xiao , Xiuli Bi
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