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We study the complexity of the problem of searching for a set of patterns that separate two given sets of strings. This problem has applications in a wide variety of areas, most notably in data mining, computational biology, and in…

Computational Complexity · Computer Science 2016-12-20 Giuseppe Lancia , Luke Mathieson , Pablo Moscato

We show that the signal-processing paradigm known as compressed sensing (CS) is applicable to genome-wide association studies (GWAS) and genomic selection (GS). The aim of GWAS is to isolate trait-associated loci, whereas GS attempts to…

Genomics · Quantitative Biology 2014-05-13 Shashaank Vattikuti , James J. Lee , Christopher C. Chang , Stephen D. H. Hsu , Carson C. Chow

Patterns of biodiversity predicted by the neutral theory rely on a simple phenomenological model of speciation. To further investigate the effect of speciation on neutral biodiversity, we analyze a spatially-explicit neutral model based on…

Populations and Evolution · Quantitative Biology 2012-07-10 Philippe Desjardins-Proulx , Dominique Gravel

This work approaches human chromosome mapping by developing algorithms for ordering markers associated with radiation hybrid data. Motivated by recent work of Boehnke et al. [1], we formulate the ordering problem by developing stochastic…

adap-org · Physics 2009-10-28 C. T. Falk , H. Falk

Large populations may contain numerous simultaneously segregating polymorphisms subject to natural selection. Since selection acts on individuals whose fitness depends on many loci, different loci affect each other's dynamics. This leads to…

Populations and Evolution · Quantitative Biology 2011-08-09 Richard A. Neher , Boris I. Shraiman

The evolution of cooperation often depends upon population structure, yet nearly all models of cooperation implicitly assume that this structure remains static. This is a simplifying assumption, because most organisms possess genetic traits…

Populations and Evolution · Quantitative Biology 2012-08-03 Simon T. Powers , Alexandra S. Penn , Richard A. Watson

Genomic data are rapidly resolving the tree of living species calibrated to time, the timetree of life, which will provide a framework for research in diverse fields of science. Previous analyses of taxonomically restricted timetrees have…

Populations and Evolution · Quantitative Biology 2014-12-16 S. Blair Hedges , Julie Marin , Michael Suleski , Madeline Paymer , Sudhir Kumar

Identification of taxa can significantly be assisted by statistical classification based on trait measurements in two major ways; either individually or by phylogenetic (clustering) methods. In this paper we present a general Bayesian…

Applications · Statistics 2021-09-17 Måns Karlsson , Ola Hössjer

In classification problems, the purpose of feature selection is to identify a small, highly discriminative subset of the original feature set. In many applications, the dataset may have thousands of features and only a few dozens of samples…

Machine Learning · Computer Science 2020-08-28 Ludmila I. Kuncheva , Clare E. Matthews , Álvar Arnaiz-González , Juan J. Rodríguez

We introduce and analyse an individual-based evolutionary model, in which a population of genetically diverse organisms compete with each other for limited resources. Through theoretical analysis and stochastic simulations, we show that the…

Populations and Evolution · Quantitative Biology 2012-11-02 Tim Rogers , Alan J. McKane , Axel G. Rossberg

In the genomic era, the identification of gene signatures associated with disease is of significant interest. Such signatures are often used to predict clinical outcomes in new patients and aid clinical decision-making. However, recent…

Methodology · Statistics 2019-03-27 Naim U. Rashid , Quefeng Li , Jen Jen Yeh , Joseph G. Ibrahim

We identify the genetic signature of a selective sweep in a population described by a birth-and-death process with density dependent competition. We study the limit behaviour for large K, where K scales the population size. We focus on two…

Probability · Mathematics 2014-12-30 Charline Smadi

Speciation is driven by many different factors. Among those are trade-offs between different ways an organism utilizes resources, and these trade-offs can constrain the manner in which selection can optimize traits. Limited migration among…

Populations and Evolution · Quantitative Biology 2014-08-12 Bjørn Østman , Randall Lin , Christoph Adami

This paper develops a simplified set of models describing asexual and sexual replication in unicel- lular diploid organisms. The models assume organisms whose genomes consist of two chromosomes, where each chromosome is assumed to be…

Populations and Evolution · Quantitative Biology 2007-09-11 Emmanuel Tannenbaum

Current theories about mechanisms promoting species co-existence in diverse communities assume that species only interact ecologically. Species are treated as discrete evolutionary entities, even though abundant empirical evidence indicates…

Populations and Evolution · Quantitative Biology 2013-11-13 Charles Cannon , Manuel Lerdau

Genetic nurture effects and assortative mating (AM) occur across many human behaviors and can bias estimates from traditional genetic models. These influences are typically studied univariately, within the same trait. However, estimation of…

Quantitative Methods · Quantitative Biology 2025-10-09 Xuanyu Lyu , Jared Balbona , Tong Chen , Matthew C. Keller

We present a spectral study of the evolution matrix of the totally asymmetric exclusion process on a ring at half filling. The natural symmetries (translation, charge conjugation combined with reflection) predict only two fold degeneracies.…

Statistical Mechanics · Physics 2009-11-10 O. Golinelli , K. Mallick

The ways in which natural selection can allow the proliferation of cooperative behavior have long been seen as a central problem in evolutionary biology. Most of the literature has focused on interactions between pairs of individuals and on…

Populations and Evolution · Quantitative Biology 2013-10-01 Roberto H. Schonmann , Renato Vicente , Nestor Caticha

We compare and contrast the long-time dynamical properties of two individual-based models of biological coevolution. Selection occurs via multispecies, stochastic population dynamics with reproduction probabilities that depend nonlinearly…

Populations and Evolution · Quantitative Biology 2011-11-10 Per Arne Rikvold

We construct a model of speciation from evolution in an ecosystem consisting of a limited amount of energy recources. The species posses genetic information, which is inherited according to the rules of the Penna model of genetic evolution.…

Soft Condensed Matter · Physics 2007-05-23 Aleksandra Nowicka , Artur Duda , Miroslaw R. Dudek