English
Related papers

Related papers: TrialSynth: Generation of Synthetic Sequential Cli…

200 papers

Data scarcity remains a significant challenge in the field of emotion recognition using physiological signals, as acquiring comprehensive and diverse datasets is often prevented by privacy concerns and logistical constraints. This…

Neural and Evolutionary Computing · Computer Science 2025-01-29 S. Muhammad Hossein Mousavi

Synthesizing clinical evidence largely relies on systematic reviews of clinical trials and retrospective analyses from medical literature. However, the rapid expansion of publications presents challenges in efficiently identifying,…

Computation and Language · Computer Science 2024-10-30 Zifeng Wang , Lang Cao , Benjamin Danek , Qiao Jin , Zhiyong Lu , Jimeng Sun

As in many fields of medical research, survival analysis has witnessed a growing interest in the application of deep learning techniques to model complex, high-dimensional, heterogeneous, incomplete, and censored medical data. Current…

Machine Learning · Computer Science 2023-12-25 Patricia A. Apellániz , Juan Parras , Santiago Zazo

In settings requiring synthetic data generation based on a clinical cohort, e.g., due to data protection regulations, heterogeneity across individuals might be a nuisance that we need to control or faithfully preserve. The sources of such…

Machine Learning · Computer Science 2023-12-14 Kiana Farhadyar , Federico Bonofiglio , Maren Hackenberg , Daniela Zoeller , Harald Binder

Synthetic data is becoming an increasingly promising technology, and successful applications can improve privacy, fairness, and data democratization. While there are many methods for generating synthetic tabular data, the task remains…

Machine Learning · Computer Science 2023-02-27 Alexander Norcliffe , Bogdan Cebere , Fergus Imrie , Pietro Lio , Mihaela van der Schaar

The generation of synthetic clinical trial data offers a promising approach to mitigating privacy concerns and data accessibility limitations in medical research. However, ensuring that synthetic datasets maintain high fidelity, utility,…

Machine Learning · Computer Science 2025-12-16 Waldemar Hahn , Jan-Niklas Eckardt , Christoph Röllig , Martin Sedlmayr , Jan Moritz Middeke , Markus Wolfien

We focus on the problem of generating high-quality, private synthetic glucose traces, a task generalizable to many other time series sources. Existing methods for time series data synthesis, such as those using Generative Adversarial…

Machine Learning · Computer Science 2023-11-01 Josephine Lamp , Mark Derdzinski , Christopher Hannemann , Joost van der Linden , Lu Feng , Tianhao Wang , David Evans

We propose a sequential variational autoencoder to learn disentangled representations of sequential data (e.g., videos and audios) under self-supervision. Specifically, we exploit the benefits of some readily accessible supervisory signals…

Computer Vision and Pattern Recognition · Computer Science 2020-05-26 Yizhe Zhu , Martin Renqiang Min , Asim Kadav , Hans Peter Graf

Preservation of private user data is of paramount importance for high Quality of Experience (QoE) and acceptability, particularly with services treating sensitive data, such as IT-based health services. Whereas anonymization techniques were…

Machine Learning · Computer Science 2024-03-04 Navid Ashrafi , Vera Schmitt , Robert P. Spang , Sebastian Möller , Jan-Niklas Voigt-Antons

High-quality synthetic data can support the development of effective predictive models for biomedical tasks, especially in rare diseases or when subject to compelling privacy constraints. These limitations, for instance, negatively impact…

Machine Learning · Computer Science 2023-01-24 Lorenzo Simone , Davide Bacciu

Clinical data usually cannot be freely distributed due to their highly confidential nature and this hampers the development of machine learning in the healthcare domain. One way to mitigate this problem is by generating realistic synthetic…

Large and well-annotated datasets are essential for advancing deep learning applications, however often costly or impossible to obtain by a single entity. In many areas, including the medical domain, approaches relying on data sharing have…

Machine Learning · Computer Science 2024-08-02 Francesco Di Salvo , David Tafler , Sebastian Doerrich , Christian Ledig

Access to individual-level health data is essential for gaining new insights and advancing science. In particular, modern methods based on artificial intelligence rely on the availability of and access to large datasets. In the health…

Access to genomic data is highly regulated due to its sensitive nature. While safeguards are essential, cumbersome data access processes pose a significant barrier to the development of AI methods for genomics. Synthetic data generation can…

Cryptography and Security · Computer Science 2026-05-01 Daniil Filienko , Martine De Cock , Sikha Pentyala

Synthetic data generation creates data based on real-world data using generative models. In health applications, generating high-quality data while maintaining fairness for sensitive attributes is essential for equitable outcomes. Existing…

Machine Learning · Computer Science 2025-06-25 Nitish Nagesh , Ziyu Wang , Amir M. Rahmani

The switch from a Model-Centric to a Data-Centric mindset is putting emphasis on data and its quality rather than algorithms, bringing forward new challenges. In particular, the sensitive nature of the information in highly regulated…

Machine Learning · Computer Science 2022-04-14 Giorgio Visani , Giacomo Graffi , Mattia Alfero , Enrico Bagli , Davide Capuzzo , Federico Chesani

The biomedical field is among the sectors most impacted by the increasing regulation of Artificial Intelligence (AI) and data protection legislation, given the sensitivity of patient information. However, the rise of synthetic data…

Machine Learning · Computer Science 2024-04-26 Eric Macias-Fassio , Aythami Morales , Cristina Pruenza , Julian Fierrez

Artificial intelligence (AI) is increasingly used in every stage of drug development. Continuing breakthroughs in AI-based methods for drug discovery require the creation, improvement, and refinement of drug discovery data. We posit a new…

Machine Learning · Computer Science 2024-05-08 Bing Hu , Ashish Saragadam , Anita Layton , Helen Chen

Single-cell perturbation prediction aims to infer how cells respond to unseen interventions and to achieve out-of-distribution (OOD) generalization, providing a computational route to understanding how perturbations reshape cellular…

Machine Learning · Computer Science 2026-05-26 Wenkang Jiang , Yuhang Liu , Erdun Gao , Ehsan Abbasnejad , Lina Yao , Javen Qinfeng Shi

Generation of realistic synthetic data has garnered considerable attention in recent years, particularly in the health research domain due to its utility in, for instance, sharing data while protecting patient privacy or determining optimal…

Other Statistics · Statistics 2025-01-30 Niki Z. Petrakos , Erica E. M. Moodie , Nicolas Savy