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Biological networks display a variety of activity patterns reflecting a web of interactions that is complex both in space and time. Yet inference methods have mainly focused on reconstructing, from the network's activity, the spatial…

Neurons and Cognition · Quantitative Biology 2015-08-19 Cristiano Capone , Carla Filosa , Guido Gigante , Federico Ricci-Tersenghi , Paolo del Giudice

Many natural and artificial networks evolve in time. Nodes and connections appear and disappear at various timescales, and their dynamics has profound consequences for any processes in which they are involved. The first empirical analysis…

Statistical Mechanics · Physics 2012-05-21 Michele Starnini , Andrea Baronchelli , Alain Barrat , Romualdo Pastor-Satorras

Revealing physical interactions in complex systems from observed collective dynamics constitutes a fundamental inverse problem in science. Current reconstruction methods require access to a system's model or dynamical data at a level of…

Physics and Society · Physics 2018-01-18 Mor Nitzan , Jose Casadiego , Marc Timme

In this paper, we consider a tree inference problem motivated by the critical problem in single-cell genomics of reconstructing dynamic cellular processes from sequencing data. In particular, given a population of cells sampled from such a…

Methodology · Statistics 2025-07-16 Elodie Maignant , Tim Conrad , Christoph von Tycowicz

We devise a machine learning technique to solve the general problem of inferring network links that have time-delays. The goal is to do this purely from time-series data of the network nodal states. This task has applications in fields…

Adaptation and Self-Organizing Systems · Physics 2021-07-28 Amitava Banerjee , Joseph D. Hart , Rajarshi Roy , Edward Ott

Understanding the structural complexity and predictability of complex networks is a central challenge in network science. Although recent studies have revealed a relationship between compression-based entropy and link prediction…

Social and Information Networks · Computer Science 2025-10-14 Sebastián Brzovic , Cristóbal Rojas , Andrés Abeliuk

Real-world complex systems such as ecological communities and neuron networks are essential parts of our everyday lives. These systems are composed of units which interact through intricate networks. The ability to predict sudden changes in…

Adaptation and Self-Organizing Systems · Physics 2019-07-05 Deniz Eroglu , Matteo Tanzi , Sebastian van Strien , Tiago Pereira

We investigate the predictive power of recurrent neural networks for oscillatory systems not only on the attractor, but in its vicinity as well. For this we consider systems perturbed by an external force. This allows us to not merely…

Adaptation and Self-Organizing Systems · Physics 2019-07-02 Rok Cestnik , Markus Abel

Cellular mechanism-of-action is of fundamental concern in many biological studies. It is of particular interest for identifying the cause of disease and learning the way in which treatments act against disease. However, pinpointing such…

Methodology · Statistics 2016-10-04 Paula J. Griffin , W. Evan Johnson , Eric D. Kolaczyk

Despite their success and widespread adoption, the opaque nature of deep neural networks (DNNs) continues to hinder trust, especially in critical applications. Current interpretability solutions often yield inconsistent or oversimplified…

Machine Learning · Computer Science 2024-10-10 Alec F. Diallo , Vaishak Belle , Paul Patras

Many complex systems change their structure over time, in these cases dynamic networks can provide a richer representation of such phenomena. As a consequence, many inference methods have been generalized to the dynamic case with the aim to…

Social and Information Networks · Computer Science 2023-10-25 Hadiseh Safdari , Martina Contisciani , Caterina De Bacco

Computational modeling is crucial for understanding and analyzing complex systems. In biology, model creation is a human dependent task that requires reading hundreds of papers and conducting wet lab experiments, which would take days or…

Quantitative Methods · Quantitative Biology 2021-10-22 Yasmine Ahmed , Natasa Miskov-Zivanov

Data-driven dynamic models of cell biology can be used to predict cell response to unseen perturbations. Recent work (CellBox) had demonstrated the derivation of interpretable models with explicit interaction terms, in which the parameters…

Molecular Networks · Quantitative Biology 2021-04-15 Weiqi Ji , Bo Yuan , Ciyue Shen , Aviv Regev , Chris Sander , Sili Deng

The problem of achieving consensus in a network of connected systems arises in many science and engineering applications. In contrast to previous works, we focus on the system reactivity, i.e., the initial amplification of the norm of the…

Systems and Control · Electrical Eng. & Systems 2023-06-21 Amirhossein Nazerian , David Phillips , Hernan A. Makse , Francesco Sorrentino

This study examines long-term trends and shifting behavior in the collaboration network of mathematics literature, using a subset of data from Mathematical Reviews spanning 1985-2009. Rather than modeling the network cumulatively, this…

The inverse statistical problem of finding direct interactions in complex networks is difficult. In the natural sciences, well-controlled perturbation experiments are widely used to probe the structure of complex networks. However, our…

Disordered Systems and Neural Networks · Physics 2019-10-24 Jialong Jiang , David A. Sivak , Matt Thomson

Predicting how the brain can be driven to specific states by means of internal or external control requires a fundamental understanding of the relationship between neural connectivity and activity. Network control theory is a powerful tool…

Neurons and Cognition · Quantitative Biology 2019-08-12 Teresa M. Karrer , Jason Z. Kim , Jennifer Stiso , Ari E. Kahn , Fabio Pasqualetti , Ute Habel , Danielle S. Bassett

The development of chemical reaction models aids understanding and prediction in areas ranging from biology to electrochemistry and combustion. A systematic approach to building reaction network models uses observational data not only to…

Computational Engineering, Finance, and Science · Computer Science 2019-01-23 Nikhil Galagali , Youssef M. Marzouk

With an increasing amount of observations on the dynamics of many complex systems, it is required to reveal the underlying mechanisms behind these complex dynamics, which is fundamentally important in many scientific fields such as climate,…

Neurons and Cognition · Quantitative Biology 2025-03-19 Zhendong Yu , Haiping Huang

One major challenge in neuroscience is the identification of interrelations between signals reflecting neural activity and how information processing occurs in the neural circuits. At the cellular and molecular level, mechanisms of signal…

Applications · Statistics 2019-09-27 Giacomo Aletti , Davide Lonardoni , Giovanni Naldi , Thierry Nieus
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