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The mechanisms driving the collective movement of cells remain poorly understood. To contribute toward resolving this mystery, a model was formulated to theoretically explore the possible functions of polarized cell-cell adhesion in…

Biological Physics · Physics 2018-04-25 Katsuyoshi Matsushita

During cell migration, cells become polarized, change their shape, and move in response to various internal and external cues. Cell polarization is defined through the spatio-temporal organization of molecules such as PI3K or small GTPases,…

Biological Physics · Physics 2016-07-07 Fabian Spill , Vivi Andasari , Michael Mak , Roger D. Kamm , Muhammad H. Zaman

Experimental evidence shows that there is a feedback between cell shape and cell motion. How this feedback impacts the collective behavior of dense cell monolayers remains an open question. We investigate the effect of a feedback that tends…

Cell sorting, the segregation of cells with different properties into distinct domains, is a key phenomenon in biological processes such as embryogenesis. We use a phase-field model of a confluent cell layer to study the role of activity in…

Biological Physics · Physics 2024-03-05 James N. Graham , Guanming Zhang , Julia M. Yeomans

We study polar molecules with long-range dipole-dipole interactions confined to move on a two-leg ladder for different orientations of the molecular dipole moments with respect to the ladder. Matrix product states are employed to calculate…

Quantum Gases · Physics 2014-01-14 Søren Gammelmark , Nikolaj Thomas Zinner

Quantifying the outcomes of cells collisions is a crucial step in building the foundations of a kinetic theory of living matter. Here, we develop a mechanical theory of such collisions by first representing individual cells as extended…

Biological Physics · Physics 2019-12-11 Pierre Recho , Thibaut Putelat , Lev Truskinovsky

Growing experimental evidence shows that cell monolayers can induce long-lived perturbations to their environment, akin to footprints, which in turn influence the global dynamics of the system. Inspired by these observations, we propose a…

Soft Condensed Matter · Physics 2024-09-10 Samuel Bell , Joseph Ackermann , Ananyo Maitra , Raphael Voituriez

We discuss the appareance of ordered structures in assemblies of magnetic particles. The phenomenon occurs when dipolar interactions and the thermal motion of the particles compete, and is mediated by screening and excluded volume effects.…

Soft Condensed Matter · Physics 2009-10-31 R. Pastor-Satorras , J. M. Rubi

Cells perform directed motion in response to external stimuli that they detect by sensing the environment with their membrane protrusions. In particular, several biochemical and biophysical cues give rise to tactic migration in the…

Cell Behavior · Quantitative Biology 2020-07-15 N. Loy , M. Conte

How the cells break symmetry and organize their edge activity to move directionally is a fun- damental question in cell biology. Physical models of cell motility commonly rely on gradients of regulatory factors and/or feedback from the…

In most models of collective motion in animal groups each individual updates its heading based on the current positions and headings of its neighbors. Several authors have investigated the effects of including anticipation into models of…

Quantitative Methods · Quantitative Biology 2021-11-23 Daniel Strömbom , Alice Antia

Cell movement and intercellular signaling occur simultaneously during the development of tissues, but little is known about how movement affects signaling. Previous theoretical studies have shown that faster moving cells favor…

Cell Behavior · Quantitative Biology 2012-05-09 Koichiro Uriu , Saul Ares , Andrew C. Oates , Luis G. Morelli

We investigate in this paper the ground state and the nature of the transition from an orientational ordered phase at low temperature to the disordered state at high temperature in a molecular crystal. Our model is a Potts model which takes…

Statistical Mechanics · Physics 2015-06-03 Danh-Tai Hoang , H. T. Diep

We present a generic framework for describing interacting, spinning, active polar particles, aimed at modelling dense cell aggregates, where cells are treated as polar, rotating objects that interact mechanically with one another and their…

Soft Condensed Matter · Physics 2024-11-01 Quentin Vagne , Guillaume Salbreux

The organization of live cells into tissues and their subsequent biological function involves inter-cell mechanical interactions, which are mediated by their elastic environment. To model this interaction, we consider cells as spherical…

Soft Condensed Matter · Physics 2024-02-20 Roman Golkov , Yair Shokef

Enzymatic molecules that actively support many cellular processes, including transport, cell division and cell motility, are known as motor proteins or molecular motors. Experimental studies indicate that they interact with each other and…

Biological Physics · Physics 2015-05-20 Daniel Celis-Garza , Hamid Teimouri , Anatoly B. Kolomeisky

We study the half filled extended Hubbard model on a two-dimensional square lattice using cluster dynamical mean field theory on clusters of size 8-20. We show that the model exhibits metallic, Mott insulating, and charge ordered phases,…

Strongly Correlated Electrons · Physics 2017-04-28 Hanna Terletska , Tianran Chen , Emanuel Gull

We show that the electric dipole-dipole interaction between a pair of polar molecules undergoes an all-out transformation when superimposed by a far-off resonant optical field. The combined interaction potential becomes tunable by variation…

Atomic Physics · Physics 2015-05-30 Mikhail Lemeshko , Bretislav Friedrich

We present a theory to investigate electro-kinetic behavior, namely, electrorotation and dielectrophoresis under alternating current (AC) applied fields for a pair of touching inhomogeneous colloidal particles and biological cells. These…

Soft Condensed Matter · Physics 2007-05-23 J. P. Huang , Mikko Karttunen , K. W. Yu , L. Dong , G. Q. Gu

Though jamming transitions are long studied in condensed matter physics and granular systems, much less is known about active jamming (or unjamming), which commonly takes place in living materials. In this paper, we explore, by molecular…

Soft Condensed Matter · Physics 2022-11-09 Varun Venkatesh , Chandana Mondal , Amin Doostmohammadi