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Recent advancements in specialized large-scale architectures for training image and language have profoundly impacted the field of computer vision and natural language processing (NLP). Language models, such as the recent ChatGPT and GPT4…

Biomolecules · Quantitative Biology 2023-05-04 Sergio Romero-Romero , Sebastian Lindner , Noelia Ferruz

Objective: To automatically create large labeled training datasets and reduce the efforts of feature engineering for training accurate machine learning models for clinical information extraction. Materials and Methods: We propose a distant…

Information Retrieval · Computer Science 2018-04-24 Yanshan Wang , Sunghwan Sohn , Sijia Liu , Feichen Shen , Liwei Wang , Elizabeth J. Atkinson , Shreyasee Amin , Hongfang Liu

Biomedical data are widely accepted in developing prediction models for identifying a specific tumor, drug discovery and classification of human cancers. However, previous studies usually focused on different classifiers, and overlook the…

Quantitative Methods · Quantitative Biology 2019-11-05 Shigang Liu , Jun Zhang , Yang Xiang , Wanlei Zhou , Dongxi Xiang

The advent of highly accurate protein structure prediction methods has fueled an exponential expansion of the protein structure database. Consequently, there is a rising demand for rapid and precise structural homolog search. Traditional…

Biomolecules · Quantitative Biology 2023-12-01 Yuan Liu , Hong-Bin Shen

Semantically meaningful sentence embeddings are important for numerous tasks in natural language processing. To obtain such embeddings, recent studies explored the idea of utilizing synthetically generated data from pretrained language…

Computation and Language · Computer Science 2022-08-31 Taehee Kim , ChaeHun Park , Jimin Hong , Radhika Dua , Edward Choi , Jaegul Choo

BACKGROUND: One of the most evident achievements of bioinformatics is the development of methods that transfer biological knowledge from characterised proteins to uncharacterised sequences. This mode of protein function assignment is mostly…

Quantitative Methods · Quantitative Biology 2007-09-28 Emmanuel D. Levy , Christos A. Ouzounis , Walter R. Gilks , Benjamin Audit

Accurately annotating and controlling protein function from sequence data remains a major challenge, particularly within homologous families where annotated sequences are scarce and structural variation is minimal. We present a two-stage…

Quantitative Methods · Quantitative Biology 2025-07-22 Lorenzo Rosset , Martin Weigt , Francesco Zamponi

This study presents a comparative analysis of deep learning methodologies such as BERT, FinBERT and ULMFiT for sentiment analysis of earnings call transcripts. The objective is to investigate how Natural Language Processing (NLP) can be…

Computation and Language · Computer Science 2026-03-24 Umair Zakir , Evan Daykin , Amssatou Diagne , Jacob Faile

Less than 1% of protein sequences are structurally and functionally annotated. Natural Language Processing (NLP) community has recently embraced self-supervised learning as a powerful approach to learn representations from unlabeled text,…

Biomolecules · Quantitative Biology 2020-12-08 Modestas Filipavicius , Matteo Manica , Joris Cadow , Maria Rodriguez Martinez

PURPOSE: The medical literature relevant to germline genetics is growing exponentially. Clinicians need tools monitoring and prioritizing the literature to understand the clinical implications of the pathogenic genetic variants. We…

Deep neural networks are powerful statistical learners. However, their predictions do not come with an explanation of their process. To analyze these models, explanation methods are being developed. We present a novel explanation method,…

Computation and Language · Computer Science 2021-01-29 David Harbecke

In recent years, machine learning has been proposed as a promising strategy to build accurate scoring functions for computational docking finalized to numerically empowered drug discovery. However, the latest studies have suggested that…

Quantitative Methods · Quantitative Biology 2023-02-17 F. Pellicani , D. Dal Ben , A. Perali , S. Pilati

In the digital era, the exponential growth of scientific publications has made it increasingly difficult for researchers to efficiently identify and access relevant work. This paper presents an automated framework for research article…

Information Retrieval · Computer Science 2025-10-08 Shadikur Rahman , Hasibul Karim Shanto , Umme Ayman Koana , Syed Muhammad Danish

Proteins, essential to biological systems, perform functions intricately linked to their three-dimensional structures. Understanding the relationship between protein structures and their amino acid sequences remains a core challenge in…

Quantitative Methods · Quantitative Biology 2024-11-04 Liang He , Peiran Jin , Yaosen Min , Shufang Xie , Lijun Wu , Tao Qin , Xiaozhuan Liang , Kaiyuan Gao , Yuliang Jiang , Tie-Yan Liu

With the yearning for deep learning democratization, there are increasing demands to implement Transformer-based natural language processing (NLP) models on resource-constrained devices for low-latency and high accuracy. Existing BERT…

Computation and Language · Computer Science 2022-06-22 Shaoyi Huang , Ning Liu , Yueying Liang , Hongwu Peng , Hongjia Li , Dongkuan Xu , Mimi Xie , Caiwen Ding

This study is main goal is to provide a comparative comparison of libraries using machine learning methods. Experts in natural language processing (NLP) are becoming more and more interested in sentiment analysis (SA) of text changes. The…

Computation and Language · Computer Science 2023-07-27 Wendy Ccoya , Edson Pinto

This paper compares the performances of three supervised machine learning algorithms in terms of predictive ability and model interpretation on structured or tabular data. The algorithms considered were scikit-learn implementations of…

Machine Learning · Statistics 2022-05-06 Alice J. Liu , Arpita Mukherjee , Linwei Hu , Jie Chen , Vijayan N. Nair

Deep learning has significantly accelerated drug discovery, with 'chemical language' processing (CLP) emerging as a prominent approach. CLP learns from molecular string representations (e.g., Simplified Molecular Input Line Entry Systems…

Biomolecules · Quantitative Biology 2025-01-13 Rıza Özçelik , Francesca Grisoni

Pre-trained models have been successful in many protein engineering tasks. Most notably, sequence-based models have achieved state-of-the-art performance on protein fitness prediction while structure-based models have been used…

Machine Learning · Computer Science 2023-07-25 Antonia Boca , Simon Mathis

Supervised machine learning (ML) algorithms are aimed at maximizing classification performance under available energy and storage constraints. They try to map the training data to the corresponding labels while ensuring generalizability to…

Machine Learning · Computer Science 2020-04-20 Ayten Ozge Akmandor , Jorge Ortiz , Irene Manotas , Bongjun Ko , Niraj K. Jha
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