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Automated protein function prediction is a challenging problem with distinctive features, such as the hierarchical organization of protein functions and the scarcity of annotated proteins for most biological functions. We propose a…

Machine Learning · Statistics 2019-04-09 Marco Frasca , Nicolò Cesa Bianchi

In the domain of network biology, the interactions among heterogeneous genomic and molecular entities are represented through networks. Link prediction (LP) methodologies are instrumental in inferring missing or prospective associations…

Molecular Networks · Quantitative Biology 2023-12-05 Ahmad F. Al Musawi , Satyaki Roy , Preetam Ghosh

During the recent years, correlation filters have shown dominant and spectacular results for visual object tracking. The types of the features that are employed in these family of trackers significantly affect the performance of visual…

Computer Vision and Pattern Recognition · Computer Science 2018-03-13 Erhan Gundogdu , A. Aydin Alatan

Deep learning models have driven significant progress in predicting protein function and interactions at the protein level. While these advancements have been invaluable for many biological applications such as enzyme engineering and…

Machine Learning · Computer Science 2025-05-20 Yang Tan , Wenrui Gou , Bozitao Zhong , Liang Hong , Huiqun Yu , Bingxin Zhou

Identifying protein-protein interactions (PPI) is crucial for gaining in-depth insights into numerous biological processes within cells and holds significant guiding value in areas such as drug development and disease treatment. Currently,…

Quantitative Methods · Quantitative Biology 2025-01-30 Jiang Li , Yuan-Ting Li

We propose a simple approach which combines the strengths of probabilistic graphical models and deep learning architectures for solving the multi-label classification task, focusing specifically on image and video data. First, we show that…

Machine Learning · Computer Science 2023-02-07 Shivvrat Arya , Yu Xiang , Vibhav Gogate

Motivation: Protein secondary structure prediction can provide important information for protein 3D structure prediction and protein functions. Deep learning, which has been successfully applied to various research fields such as image…

Quantitative Methods · Quantitative Biology 2017-09-20 Chao Fang , Yi Shang , Dong Xu

Biological networks provide insight into the complex organization of biological processes in a cell at the system level. They are an effective tool for understanding the comprehensive map of functional interactions, finding the functional…

Molecular Networks · Quantitative Biology 2017-09-14 Somaye Hashemifar

Deep reinforcement learning (DRL) has shown remarkable performance on complex control problems in systems and networking, including adaptive video streaming, wireless resource management, and congestion control. For safe deployment,…

Networking and Internet Architecture · Computer Science 2026-04-07 Mohammad Zangooei , Jannis Weil , Amr Rizk , Mina Tahmasbi Arashloo , Raouf Boutaba

Protein language models (pLMs) pre-trained on vast protein sequence databases excel at various downstream tasks but often lack the structural knowledge essential for some biological applications. To address this, we introduce a method to…

Data selection is one of the fundamental problems in neural network training, particularly for multi-layer perceptrons (MLPs) where identifying the most valuable training samples from massive, multi-source, and heterogeneous data sources…

Machine Learning · Computer Science 2025-10-27 Xiyang Zhang , Chen Liang , Haoxuan Qiu , Hongzhi Wang

Neural Networks (GNNs) have revolutionized the molecular discovery to understand patterns and identify unknown features that can aid in predicting biophysical properties and protein-ligand interactions. However, current models typically…

Machine Learning · Computer Science 2022-12-21 Carter Knutson , Gihan Panapitiya , Rohith Varikoti , Neeraj Kumar

Human action recognition remains an important yet challenging task. This work proposes a novel action recognition system. It uses a novel Multiple View Region Adaptive Multi-resolution in time Depth Motion Map (MV-RAMDMM) formulation…

Computer Vision and Pattern Recognition · Computer Science 2019-04-15 Mahmoud Al-Faris , John P. Chiverton , Yanyan Yang , David L. Ndzi

Signaling proteins are an important topic in drug development due to the increased importance of finding fast, accurate and cheap methods to evaluate new molecular targets involved in specific diseases. The complexity of the protein…

Quantitative Methods · Quantitative Biology 2019-04-11 Carlos Fernandez-Lozano , Ruben F. Cuinas , Jose A. Seoane , Enrique Fernandez-Blanco , Julian Dorado , Cristian R. Munteanu

The quest for biologically plausible deep learning is driven, not just by the desire to explain experimentally-observed properties of biological neural networks, but also by the hope of discovering more efficient methods for training…

Machine Learning · Computer Science 2017-11-22 Zuozhu Liu , Tony Q. S. Quek , Shaowei Lin

High-dimensional images, known for their rich semantic information, are widely applied in remote sensing and other fields. The spatial information in these images reflects the object's texture features, while the spectral information…

Computer Vision and Pattern Recognition · Computer Science 2023-11-21 Daixun Li , Weiying Xie , Jiaqing Zhang , Yunsong Li

Proteins are the main workhorses of biological functions in a cell, a tissue, or an organism. Identification and quantification of proteins in a given sample, e.g. a cell type under normal/disease conditions, are fundamental tasks for the…

Computational Engineering, Finance, and Science · Computer Science 2017-10-10 Ngoc Hieu Tran , Zachariah Levine , Lei Xin , Baozhen Shan , Ming Li

Reliable seed yield estimation is an indispensable step in plant breeding programs geared towards cultivar development in major row crops. The objective of this study is to develop a machine learning (ML) approach adept at soybean…

Protein-ligand binding affinity (PLBA) prediction is the fundamental task in drug discovery. Recently, various deep learning-based models predict binding affinity by incorporating the three-dimensional structure of protein-ligand complexes…

Biomolecules · Quantitative Biology 2023-12-21 Jiaxian Yan , Zhaofeng Ye , Ziyi Yang , Chengqiang Lu , Shengyu Zhang , Qi Liu , Jiezhong Qiu

In 3D shape recognition, multi-view based methods leverage human's perspective to analyze 3D shapes and have achieved significant outcomes. Most existing research works in deep learning adopt handcrafted networks as backbones due to their…

Computer Vision and Pattern Recognition · Computer Science 2020-12-11 Zhaoqun Li , Hongren Wang , Jinxing Li