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The classification performance of the random vector functional link (RVFL), a randomized neural network, has been widely acknowledged. However, due to its shallow learning nature, RVFL often fails to consider all the relevant information…

Machine Learning · Computer Science 2025-02-11 M. Tanveer , R. K. Sharma , M. Sajid , A. Quadir

Multimodal protein features play a crucial role in protein function prediction. However, these features encompass a wide range of information, ranging from structural data and sequence features to protein attributes and interaction…

Machine Learning · Computer Science 2025-11-07 Xiaoling Luo , Peng Chen , Chengliang Liu , Xiaopeng Jin , Jie Wen , Yumeng Liu , Junsong Wang

Neural networks have been successfully employed in various domains such as classification, regression and clustering, etc. Generally, the back propagation (BP) based iterative approaches are used to train the neural networks, however, it…

Neural and Evolutionary Computing · Computer Science 2023-06-23 A. K. Malik , Ruobin Gao , M. A. Ganaie , M. Tanveer , P. N. Suganthan

In this paper, we propose a deep learning framework based on randomized neural network. In particular, inspired by the principles of Random Vector Functional Link (RVFL) network, we present a deep RVFL network (dRVFL) with stacked layers.…

Computer Vision and Pattern Recognition · Computer Science 2019-07-02 Rakesh Katuwal , P. N. Suganthan , M. Tanveer

In this paper, we first introduce batch normalization to the edRVFL network. This re-normalization method can help the network avoid divergence of the hidden features. Then we propose novel variants of Ensemble Deep Random Vector Functional…

Machine Learning · Computer Science 2022-01-24 Qiushi Shi , Ponnuthurai Nagaratnam Suganthan , Rakesh Katuwal

Protein representation learning is critical in various tasks in biology, such as drug design and protein structure or function prediction, which has primarily benefited from protein language models and graph neural networks. These models…

Biomolecules · Quantitative Biology 2024-02-16 Bozhen Hu , Zelin Zang , Cheng Tan , Stan Z. Li

DNA-binding proteins are a class of proteins which have a specific or general affinity to DNA and include three important components: transcription factors; nucleases, and histones. DNA-binding proteins also perform important roles in many…

Computer Vision and Pattern Recognition · Computer Science 2012-07-12 Sokyna Qatawneh , Afaf Alneaimi , Thamer Rawashdeh , Mmohammad Muhairat , Rami Qahwaji , Stan Ipson

Identifying DNA- (DBPs) and RNA-binding proteins (RBPs) is crucial for the understanding of cell function, molecular interactions as well as regulatory functions. Owing to their high similarity, most of the existing approaches face…

Quantitative Methods · Quantitative Biology 2025-10-22 Nimisha Ghosh , Dheeran Sankaran , Rahul Balakrishnan Adhi , Sharath S , Amrut Anand

Proteins are the basic building blocks of life. They usually perform functions by folding to a particular structure. Understanding the folding process could help the researchers to understand the functions of proteins and could also help to…

Computational Engineering, Finance, and Science · Computer Science 2015-10-21 Jianzhu Ma

Predicting protein secondary structure is essential for understanding protein function and advancing drug discovery. However, the intricate sequence-structure relationship poses significant challenges for accurate modeling. To address…

Machine Learning · Computer Science 2026-03-16 Yining Qian , Lijie Su , Meiling Xu , Xianpeng Wang

Protein (receptor)--ligand interaction prediction is a critical component in computer-aided drug design, significantly influencing molecular docking and virtual screening processes. Despite the development of numerous scoring functions in…

Biomolecules · Quantitative Biology 2024-01-22 Haoyu Lin , Shiwei Wang , Jintao Zhu , Yibo Li , Jianfeng Pei , Luhua Lai

Composed of amino acid chains that influence how they fold and thus dictating their function and features, proteins are a class of macromolecules that play a central role in major biological processes and are required for the structure,…

Quantitative Methods · Quantitative Biology 2022-07-15 Aaron Wang

Randomized neural networks (NNs) are an interesting alternative to conventional NNs that are more used for data modeling. The random vector functional-link (RVFL) network is an established and theoretically well-grounded randomized learning…

Computation · Statistics 2018-04-24 Hien D. Nguyen , Dianhui Wang , Geoffrey J. McLachlan

Multi-View Representation Learning (MVRL) aims to derive a unified representation from multi-view data by leveraging shared and complementary information across views. However, when views are irregularly missing, the incomplete data can…

Machine Learning · Computer Science 2025-03-03 Xin Gao , Jian Pu

This paper is concerned with multi-view reinforcement learning (MVRL), which allows for decision making when agents share common dynamics but adhere to different observation models. We define the MVRL framework by extending partially…

Machine Learning · Computer Science 2019-10-21 Minne Li , Lisheng Wu , Haitham Bou Ammar , Jun Wang

Protein-RNA interactions are of vital importance to a variety of cellular activities. Both experimental and computational techniques have been developed to study the interactions. Due to the limitation of the previous database, especially…

Biomolecules · Quantitative Biology 2021-11-24 Junkang Wei , Siyuan Chen , Licheng Zong , Xin Gao , Yu Li

This paper presents a deep learning-based framework for predicting the dynamic performance of suspension systems in multi-axle vehicles, emphasizing the integration of machine learning with traditional vehicle dynamics modeling. A…

Machine Learning · Computer Science 2024-10-04 Kai Chun Lin , Bo-Yi Lin

The performance of video prediction has been greatly boosted by advanced deep neural networks. However, most of the current methods suffer from large model sizes and require extra inputs, e.g., semantic/depth maps, for promising…

Computer Vision and Pattern Recognition · Computer Science 2023-03-27 Xiaotao Hu , Zhewei Huang , Ailin Huang , Jun Xu , Shuchang Zhou

Predicting accurate protein-ligand binding affinity is important in drug discovery but remains a challenge even with computationally expensive biophysics-based energy scoring methods and state-of-the-art deep learning approaches. Despite…

Stochastic processes that involve the creation of objects and relations over time are widespread, but relatively poorly studied. For example, accurate fault diagnosis in factory assembly processes requires inferring the probabilities of…

Artificial Intelligence · Computer Science 2011-09-13 P. Domingos , S. Sanghai , D. Weld
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