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Accurate segmentation of 3-D cell nuclei in microscopy images is essential for the study of nuclear organization, gene expression, and cell morphodynamics. Current image segmentation methods are challenged by the complexity and variability…

Image and Video Processing · Electrical Eng. & Systems 2022-03-18 Sundaresh Ram , Jeffrey J. Rodriguez

Segmentation of objects in microscopy images is required for many biomedical applications. We introduce object-centric embeddings (OCEs), which embed image patches such that the spatial offsets between patches cropped from the same object…

Machine Learning · Computer Science 2023-10-13 Steffen Wolf , Manan Lalit , Henry Westmacott , Katie McDole , Jan Funke

Nuclei instance segmentation in hematoxylin and eosin (H&E)-stained images plays an important role in automated histological image analysis, with various applications in downstream tasks. While several machine learning and deep learning…

Computer Vision and Pattern Recognition · Computer Science 2026-01-29 Nima Torbati , Anastasia Meshcheryakova , Ramona Woitek , Sepideh Hatamikia , Diana Mechtcheriakova , Amirreza Mahbod

Breast tumor segmentation is a critical task in computer-aided diagnosis (CAD) systems for breast cancer detection because accurate tumor size, shape and location are important for further tumor quantification and classification. However,…

Image and Video Processing · Electrical Eng. & Systems 2020-09-29 Bryar Shareef , Alex Vakanski , Min Xian , Phoebe E. Freer

Segmenting object instances is a key task in machine perception, with safety-critical applications in robotics and autonomous driving. We introduce a novel approach to instance segmentation that jointly leverages measurements from multiple…

Computer Vision and Pattern Recognition · Computer Science 2022-10-18 Alex Zihao Zhu , Vincent Casser , Reza Mahjourian , Henrik Kretzschmar , Sören Pirk

Imaging assays of cellular function, especially those using fluorescent stains, are ubiquitous in the biological and medical sciences. Despite advances in computer vision, such images are often analyzed using only manual or rudimentary…

Computer Vision and Pattern Recognition · Computer Science 2017-06-06 Lena R. Bartell , Lawrence J. Bonassar , Itai Cohen

Most state-of-the-art instance segmentation methods have to be trained on densely annotated images. While difficult in general, this requirement is especially daunting for biomedical images, where domain expertise is often required for…

Computer Vision and Pattern Recognition · Computer Science 2022-04-05 Adrian Wolny , Qin Yu , Constantin Pape , Anna Kreshuk

The accurate segmentation and tracking of cells in microscopy image sequences is an important task in biomedical research, e.g., for studying the development of tissues, organs or entire organisms. However, the segmentation of touching…

Computer Vision and Pattern Recognition · Computer Science 2020-12-10 Tim Scherr , Katharina Löffler , Moritz Böhland , Ralf Mikut

In computational pathology, nuclear instance segmentation is a fundamental task with many downstream clinical applications. With the advent of deep learning, many approaches, including convolutional neural networks (CNNs) and vision…

Computer Vision and Pattern Recognition · Computer Science 2026-05-06 Amirreza Mahbod , Ramona Woitek , Jeanne Shen

Efficient single instance segmentation is essential for unlocking features in the mobile imaging applications, such as capture or editing. Existing on-the-fly mobile imaging applications scope the segmentation task to portraits or the…

Computer Vision and Pattern Recognition · Computer Science 2025-08-28 Mingyuan Wu , Zichuan Liu , Haozhen Zheng , Hongpeng Guo , Bo Chen , Xin Lu , Klara Nahrstedt

We study the problem of instance segmentation in biological images with crowded and compact cells. We formulate this task as an integer program where variables correspond to cells and constraints enforce that cells do not overlap. To solve…

Computer Vision and Pattern Recognition · Computer Science 2017-09-22 Chong Zhang , Shaofei Wang , Miguel A. Gonzalez-Ballester , Julian Yarkony

3D instance segmentation methods often require fully-annotated dense labels for training, which are costly to obtain. In this paper, we present ClickSeg, a novel click-level weakly supervised 3D instance segmentation method that requires…

Computer Vision and Pattern Recognition · Computer Science 2023-07-20 Leyao Liu , Tao Kong , Minzhao Zhu , Jiashuo Fan , Lu Fang

Current state-of-the-art instance segmentation methods are not suited for real-time applications like autonomous driving, which require fast execution times at high accuracy. Although the currently dominant proposal-based methods have high…

Computer Vision and Pattern Recognition · Computer Science 2019-08-05 Davy Neven , Bert De Brabandere , Marc Proesmans , Luc Van Gool

We present a simple and effective framework for simultaneous semantic segmentation and instance segmentation with Fully Convolutional Networks (FCNs). The method, called BiSeg, predicts instance segmentation as a posterior in Bayesian…

Computer Vision and Pattern Recognition · Computer Science 2017-07-19 Viet-Quoc Pham , Satoshi Ito , Tatsuo Kozakaya

We present Q-Seg, a novel unsupervised image segmentation method based on quantum annealing, tailored for existing quantum hardware. We formulate the pixel-wise segmentation problem, which assimilates spectral and spatial information of the…

Computer Vision and Pattern Recognition · Computer Science 2024-09-06 Supreeth Mysore Venkatesh , Antonio Macaluso , Marlon Nuske , Matthias Klusch , Andreas Dengel

Promptable segmentation foundation models have emerged as a transformative approach to addressing the diverse needs in medical images, but most existing models require expensive computing, posing a big barrier to their adoption in clinical…

The segmentation of cell nuclei in tissue images stained with the blood dye hematoxylin and eosin (H$\&$E) is essential for various clinical applications and analyses. Due to the complex characteristics of cellular morphology, a large…

Image and Video Processing · Electrical Eng. & Systems 2024-07-26 Ziwei Cui , Jingfeng Yao , Lunbin Zeng , Juan Yang , Wenyu Liu , Xinggang Wang

Instance segmentation in remote sensing images is a long-standing challenge. Since horizontal bounding boxes introduce many interference objects, oriented bounding boxes (OBBs) are usually used for instance identification. However, based on…

Computer Vision and Pattern Recognition · Computer Science 2025-12-01 Zhen Zhou , Junfeng Fan , Yunkai Ma , Sihan Zhao , Fengshui Jing , Min Tan

Object segmentation is an important step in the workflow of computational pathology. Deep learning based models generally require large amount of labeled data for precise and reliable prediction. However, collecting labeled data is…

Computer Vision and Pattern Recognition · Computer Science 2020-07-08 Navid Alemi Koohbanani , Mostafa Jahanifar , Neda Zamani Tajadin , Nasir Rajpoot

Recently, automated medical image segmentation methods based on deep learning have achieved great success. However, they heavily rely on large annotated datasets, which are costly and time-consuming to acquire. Few-shot learning aims to…

Artificial Intelligence · Computer Science 2024-08-20 Jiayu Huo , Ruiqiang Xiao , Haotian Zheng , Yang Liu , Sebastien Ourselin , Rachel Sparks