Related papers: Electron FLASH platform for pre-clinical research:…
FLASH radiotherapy (FLASH-RT) achieves tumor control comparable to conventional dose-rate irradiation (CONV-RT) while significantly reducing radiation damage to normal tissues. However, the physical conditions triggering the FLASH sparing…
The differential sparing of normal tissues relative to tumor control observed at ultra-high dose rates, referred to as the FLASH effect, has recently gained considerable attention. The therapeutic advantages of FLASH radiotherapy are…
The FLASH effect refers to a lower normal tissue damage for an equivalent tumour response, potentially widening the therapeutic window for radiotherapy. Although this effect has been demonstrated in various experiments using different types…
Recently, shoot-through proton FLASH has been proposed where the highest energy is extracted from the cyclotron to maximize the dose rate (DR). Even though our proton pencil beam scanning system can deliver 250 MeV (the highest energy), it…
SPARC_LAB is a high-brightness electron photoinjector dedicated to FEL radiation production and research on novel acceleration techniques. It has been in operation at LNF since 2005. It is composed of a newly designed brazeless 1.6-cell…
The electron and positron accelerator complex at KEK offers unique experimental opportunities in the fields of elementary particle physics with SuperKEKB collider and photon science with two light sources. In order to maximize the…
Standard 6 megavolt (MV) radiotherapy is limited by source size and secondary electron range to minimum radiological penumbra widths of ~2-3 mm. This study investigates sharper beams via upright radiotherapy with lower energies and extended…
An S-band linear accelerator is the source of particles and the front end of the Advanced Photon Source injector. In addition, it supports a low-energy undulator test line (LEUTL) and drives a free-electron laser (FEL). A…
Objective: This study aims to investigate the influence of organ architecture (specifically the distinction between serial and parallel tissue) on the protective FLASH effect when organs are irradiated with inhomogeneous dose distributions.…
Charged particle therapy, or so-called hadrontherapy, is developing very rapidly. There is large pressure on the scientific community to deliver dedicated accelerators, providing the best possible treatment modalities at the lowest cost. In…
Recent results from animal irradiation studies have rekindled interest in the potential of ultra-high dose rate irradiation (also known as FLASH) for reducing normal tissue toxicity. However, despite mounting evidence of a "FLASH effect", a…
In this paper, we proposed a method to optimize adaptive proton FLASH therapy (ADP FLASH) using modularized pin ridge filters (pRFs) by recycling module pins from the initial plan while reducing pRF adjustments in adaptive FLASH planning.…
Modern data science relies on data analytic pipelines to organize interdependent computational steps. Such analytic pipelines often involve different algorithms across multiple steps, each with its own hyperparameters. To achieve the best…
Proton FLASH therapy leverages ultra-high dose-rate radiation to enhance the sparing of organs at risk without compromising tumor control probability. To prepare for the delivery of high doses to targets, we aim to develop a deep…
Magnetic resonance imaging-guided linear accelerators (MRI-Linacs) are an emerging treatment technology that enable online soft-tissue visualisation and adaptive radiotherapy. The Australian 1.0 T MRI-Linac employs a fixed, inline beamline,…
Radiotherapy is part of the treatment of over 50% of cancer patients. Its efficacy is limited by the radiotoxicity to the healthy tissue. FLASH-RT is based on the biological effect that ultra-high dose rates (UHDR) and very short treatment…
We consider physics behind the FLASH modality of cancer radiation treatment where extremely short treatment times are achieved with ultra high dose rates maintaining the conventional antitumor effectiveness and yet substantially reducing…
FLASH-RT has proven beneficial in preclinical studies. However, the lack of accurate real time 2D dosimetry is a limiting factor. In this work, an innovative solution for 2D real time dosimetry in UHDR electron beams is presented. The…
Commercial treatment planning systems for electron FLASH radiotherapy are unavailable, and the dosimetric precision required for ultra-high dose rate delivery makes Monte Carlo (MC) simulation the gold standard approach. This work…
Manual annotation of pathology slides for cancer diagnosis is laborious and repetitive. Therefore, much effort has been devoted to develop computer vision solutions. Our approach, (FLASH), is based on a Deep Convolutional Neural Network…