Related papers: Electron FLASH platform for pre-clinical research:…

Objectives. This study develops and validates a vacuum-based alpha irradiation platform to support preclinical radiobiology. We aim to demonstrate precise, independent control over incident energy, fluence rate, and spatiotemporal patterns,…

FLASH radiotherapy necessitates the development of advanced Quality Assurance methods and detectors for accurate and online monitoring of the radiation field. This study introduces enhanced time-resolution detection systems and methods…

FLASH Radiotherapy (RT) is a potentially new cancer radiotherapy technique where an entire therapeutic dose is delivered in about 0.1 s and at ~1000 times higher dose rate than in conventional RT. For clinical trials to be conducted safely,…

The successful operation of X-ray free-electron lasers (FELs), like the Linac Coherent Light Source or the Free-Electron Laser in Hamburg (FLASH), makes unprecedented research on matter at atomic length and ultrafast time scales possible.…

Ultra high dose rate electron beams also known as FLASH radiotherapy is becoming of importance in several preclinial cancer treatment studies. However, due to the dose rate used during the irradiation sessions, no real time dose monitoring…

Radiotherapy with Very High Energy Electron (VHEE) beams is being extensively investigated for the treatment of deep-seated tumours, even in view of novel protocols based on the so-called FLASH effect. Laser WakeField Acceleration (LWFA)…

Configuring clinical linear accelerators (linacs) for ultra-high dose rate (UHDR) electron experiments typically requires invasive hardware manipulation and/or irreversible manufacturer modifications, limiting broader implementation. We…

The FLASHForward experimental facility is a high-performance test-bed for precision plasma-wakefield research, aiming to accelerate high-quality electron beams to GeV-levels in a few centimetres of ionised gas. The plasma is created by…

Conventional cancer therapies include surgery, radiation therapy, chemotherapy, and, more recently, immunotherapy. These modalities are often combined to improve the therapeutic index. The general concept of radiation therapy is to increase…

Irradiations at Ultra High Dose Rate (UHDR) regimes, exceeding 40 Gy/s in single fractions lasting less than 200 ms, have shown an equivalent antitumor effect compared to conventional radio-therapy with reduced harm to normal tissues. This…

The FLASH effect, characterized by potential sparing of organs at risk (OAR) through ultra-high dose rate irradiation, has garnered significant attention for its capability to address indications previously untreatable at conventional dose…

Objective: In this study, a fast imaging technique was developed for the first in vivo Cherenkov emission imaging from an ultra-high dose rate (UHDR) electron beam source at single pulse (360 Hz) submillimeter resolution. Approach: A CMOS…

FLASH radiotherapy (FLASH-RT) is a new modality of radiotherapy by delivering doses with ultra-high dose rates. FLASH-RT has the ability to suppress tumor growth while sparing normal tissues, known as the FLASH effect. Although FLASH effect…

Background: Use of a linear accelerator in ultra-high dose rate (UHDR) mode can provide a conduit for wider access to UHDR FLASH effects, sparing normal tissue, but care needs to be taken in the use of such systems to ensure errors are…

Background: The normal tissue sparing effect of ultra-high dose rate irradiation (>40 Gy/s, UHDR), as compared to conventional dose rate (CONV), has attracted significant research interest for FLASH radiotherapy (RT). Accurate, dose rate…

We previously developed a FLASH planning framework for streamlined pin-ridge-filter (pin-RF) design, demonstrating its feasibility for single-energy proton FLASH planning. In this study, we refined the pin-RF design for easy assembly using…

Ultra-high dose rate radiation therapy (FLASH) based on proton irradiation is of major interest for cancer treatments but creates new challenges for dose monitoring. Amorphous hydrogenated silicon is known to be one of the most…

Experimental results, supported by precise modelling, demonstrate optimisation of a plasma-based injector with intermediate laser pulse energy ($<1$ J), corresponding to a normalised vector potential $a_0 = 2.15$, using ionisation injection…

Background and Objective: Recent experimental studies using ultra-high dose rate radiation therapy (FLASH-RT) have shown improved normal tissue sparing and comparable tumor control compared to conventional dose rate RT. Pencil beam scanning…

Purpose: This study aims to investigate the impact of the beam temporal profile on the radical dynamics and inter-track interactions of FLASH radiotherapy, supporting parameter optimization for the equipment development and clinical…