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Large Language Models (LLMs) have recently garnered significant attention, primarily for their capabilities in text-based interactions. However, natural human interaction often relies on speech, necessitating a shift towards voice-based…

Computation and Language · Computer Science 2025-08-08 Wenqian Cui , Dianzhi Yu , Xiaoqi Jiao , Ziqiao Meng , Guangyan Zhang , Qichao Wang , Yiwen Guo , Irwin King

Large Language Models (LLMs) have become instrumental across various applications, with the customization of these models to specific scenarios becoming increasingly critical. System message, a fundamental component of LLMs, is consist of…

Computation and Language · Computer Science 2024-10-23 Yanzhao Qin , Tao Zhang , Tao Zhang , Yanjun Shen , Wenjing Luo , Haoze Sun , Yan Zhang , Yujing Qiao , Weipeng Chen , Zenan Zhou , Wentao Zhang , Bin Cui

Large language models (LLMs) have recently demonstrated state-of-the-art performance across various natural language processing (NLP) tasks, achieving near-human levels in multiple language understanding challenges and aligning closely with…

Signal Processing · Electrical Eng. & Systems 2025-07-08 Zhenyi Wang , Li Zou , Shengyun Wei , Kai Li , Feifan Liao , Haibo Mi , Rongxuan Lai

The unprecedented advancements in Large Language Models (LLMs) have profoundly impacted natural language processing but have yet to fully embrace the realm of scalable vector graphics (SVG) generation. While LLMs encode partial knowledge of…

Computer Vision and Pattern Recognition · Computer Science 2025-03-26 Ximing Xing , Juncheng Hu , Guotao Liang , Jing Zhang , Dong Xu , Qian Yu

Travel choice analysis is crucial for understanding individual travel behavior to develop appropriate transport policies and recommendation systems in Intelligent Transportation Systems (ITS). Despite extensive research, this domain faces…

Artificial Intelligence · Computer Science 2024-06-25 Xuehao Zhai , Hanlin Tian , Lintong Li , Tianyu Zhao

Large language models (LLMs) have significantly advanced in various fields and intelligent agent applications. However, current LLMs that learn from human or external model supervision are costly and may face performance ceilings as task…

Computation and Language · Computer Science 2024-06-04 Zhengwei Tao , Ting-En Lin , Xiancai Chen , Hangyu Li , Yuchuan Wu , Yongbin Li , Zhi Jin , Fei Huang , Dacheng Tao , Jingren Zhou

Large Language Models (LLMs) are rapidly reshaping machine translation (MT), particularly by introducing instruction-following, in-context learning, and preference-based alignment into what has traditionally been a supervised…

Computation and Language · Computer Science 2026-04-29 Baban Gain , Dibyanayan Bandyopadhyay , Asif Ekbal , Trilok Nath Singh

Protein Language Models (PLMs) have emerged as performant and scalable tools for predicting the functional impact and clinical significance of protein-coding variants, but they still lag experimental accuracy. Here, we present a novel…

Large Language Models (LLMs) are central to the one-for-all intelligent paradigm, but they face a fundamental challenge when dealing with heterogeneous scientific data such as molecules: the inherent gap between discrete linguistic symbols…

Artificial Intelligence · Computer Science 2026-05-22 Yuxuan Chen , Changwei Lv , Yunduo Xiao , Zhongjing Du , Daquan Zhou , Yukun Yan , Zheni Zeng , Zhiyuan Liu

The applications of large language models (LLMs) are promising for biomedical and healthcare research. Despite the availability of open-source LLMs trained using a wide range of biomedical data, current research on the applications of LLMs…

Machine Learning · Computer Science 2024-09-25 Tianyu Liu , Yijia Xiao , Xiao Luo , Hua Xu , W. Jim Zheng , Hongyu Zhao

Proteins perform their biological functions through three-dimensional structures encoded by amino acid sequences, and ligand-binding protein co-design requires models that generate sequence-structure compatible proteins under explicit…

Biomolecules · Quantitative Biology 2026-05-28 Chen Wei , Fanding Xu , Minghao Sun , Zhiyuan Liu , Lin Wang , Tianrui Jia , Yihang Zhou , Yang Zhang

Protein language models (PLMs) have emerged as powerful tools to detect complex patterns of protein sequences. However, the capability of PLMs to fully capture information on protein sequences might be limited by focusing on single…

Machine Learning · Computer Science 2025-05-27 Hazem Alsamkary , Mohamed Elshaffei , Mohamed Elkerdawy , Ahmed Elnaggar

We present MiMo-7B, a large language model born for reasoning tasks, with optimization across both pre-training and post-training stages. During pre-training, we enhance the data preprocessing pipeline and employ a three-stage data mixing…

Language models are powerful tools for molecular design. Currently, the dominant paradigm is to parse molecular graphs into linear string representations that can easily be trained on. This approach has been very successful, however, it is…

Machine Learning · Computer Science 2023-05-11 Daniel Flam-Shepherd , Alán Aspuru-Guzik

The evolving requirements of Internet of Things (IoT) applications are driving an increasing shift toward bringing intelligence to the edge, enabling real-time insights and decision-making within resource-constrained environments. Tiny…

Software Engineering · Computer Science 2025-04-08 Guanghan Wu , Sasu Tarkoma , Roberto Morabito

While protein language models (pLMs) have transformed biological research, the scaling laws governing their improvement remain underexplored. By adapting methodologies from NLP scaling laws, we investigated the optimal ratio between model…

Biomolecules · Quantitative Biology 2024-06-27 Yaiza Serrano , Álvaro Ciudad , Alexis Molina

Deep learning has been widely used for protein engineering. However, it is limited by the lack of sufficient experimental data to train an accurate model for predicting the functional fitness of high-order mutants. Here, we develop SESNet,…

Quantitative Methods · Quantitative Biology 2023-04-10 Mingchen Li , Liqi Kang , Yi Xiong , Yu Guang Wang , Guisheng Fan , Pan Tan , Liang Hong

Large language models (LLMs) are capable of emulating reasoning and using tools, creating opportunities for autonomous agents that execute complex scientific tasks. Protein design provides a natural testbed: although machine learning (ML)…

Large language models (LLMs) offer new opportunities for automated data extraction and property prediction across materials science, yet their use in superconductivity research remains limited. Here we construct a large experimental…

Materials Science · Physics 2025-12-12 Suman Itani , Yibo Zhang , Ranjit Itani , Jiadong Zang
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