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Generating high-fidelity and biologically plausible synthetic single-cell RNA sequencing (scRNA-seq) data, especially with conditional control, is challenging due to its high dimensionality, sparsity, and complex biological variations.…

Machine Learning · Computer Science 2025-06-17 Lorenzo Bini , Stephane Marchand-Maillet

To build a flexible and interpretable model for document analysis, we develop deep autoencoding topic model (DATM) that uses a hierarchy of gamma distributions to construct its multi-stochastic-layer generative network. In order to provide…

Machine Learning · Computer Science 2020-06-17 Hao Zhang , Bo Chen , Yulai Cong , Dandan Guo , Hongwei Liu , Mingyuan Zhou

Artificial intelligence (AI) is increasingly used in every stage of drug development. Continuing breakthroughs in AI-based methods for drug discovery require the creation, improvement, and refinement of drug discovery data. We posit a new…

Machine Learning · Computer Science 2024-05-08 Bing Hu , Ashish Saragadam , Anita Layton , Helen Chen

Diffusion models have demonstrated their effectiveness across various generative tasks. However, when applied to medical image segmentation, these models encounter several challenges, including significant resource and time requirements.…

Computer Vision and Pattern Recognition · Computer Science 2024-07-10 Tianyu Lin , Zhiguang Chen , Zhonghao Yan , Weijiang Yu , Fudan Zheng

Generative models can be categorized into two types: explicit generative models that define explicit density forms and allow exact likelihood inference, such as score-based diffusion models (SDMs) and normalizing flows; implicit generative…

Machine Learning · Statistics 2023-07-06 Jingwei Zhang , Han Shi , Jincheng Yu , Enze Xie , Zhenguo Li

As a powerful tool for characterizing cellular subpopulations and cellular heterogeneity, single cell RNA sequencing (scRNA-seq) technology offers advantages of high throughput and multidimensional analysis. However, the process of data…

Machine Learning · Computer Science 2024-11-19 Zhuorui Cui , Shengze Dong , Ding Liu

Synthesising a text-to-image model of high-quality images by guiding the generative model through the Text description is an innovative and challenging task. In recent years, AttnGAN based on the Attention mechanism to guide GAN training…

Computer Vision and Pattern Recognition · Computer Science 2023-07-07 Mingyu Jin , Chong Zhang , Qinkai Yu , Haochen Xue , Xiaobo Jin , Xi Yang

Diffusion Models have become a cornerstone of modern generative AI for their exceptional generation quality and controllability. However, their inherent \textit{multi-step iterations} and \textit{complex backbone networks} lead to…

Influenced by breakthroughs in LLMs, single-cell foundation models are emerging. While these models show successful performance in cell type clustering, phenotype classification, and gene perturbation response prediction, it remains to be…

Data augmentation for domain-specific image classification tasks often struggles to simultaneously address diversity, faithfulness, and label clarity of generated data, leading to suboptimal performance in downstream tasks. While existing…

Computer Vision and Pattern Recognition · Computer Science 2025-05-20 Yixuan Dong , Fang-Yi Su , Jung-Hsien Chiang

Generative models for tabular data have evolved rapidly beyond Generative Adversarial Networks (GANs). While GANs pioneered synthetic tabular data generation, recent advances in diffusion models and large language models (LLMs) have opened…

Machine Learning · Computer Science 2026-04-10 Insaf Ashrapov

Diffusion models have recently shown strong potential in both music generation and music source separation tasks. Although in early stages, a trend is emerging towards integrating these tasks into a single framework, as both involve…

Sound · Computer Science 2024-12-31 Tornike Karchkhadze , Mohammad Rasool Izadi , Shlomo Dubnov

RNA-Seq technology allows for studying the transcriptional state of the cell at an unprecedented level of detail. Beyond quantification of whole-gene expression, it is now possible to disentangle the abundance of individual alternatively…

Genomics · Quantitative Biology 2012-10-11 Barbara Rakitsch , Christoph Lippert , Hande Topa , Karsten Borgwardt , Antti Honkela , Oliver Stegle

Multimodal neuroimaging provides complementary insights for Alzheimer's disease diagnosis, yet clinical datasets frequently suffer from missing modalities. We propose ACADiff, a framework that synthesizes missing brain imaging modalities…

Computer Vision and Pattern Recognition · Computer Science 2026-03-11 Rong Zhou , Houliang Zhou , Yao Su , Brian Y. Chen , Yu Zhang , Lifang He , Alzheimer's Disease Neuroimaging Initiative

Training diffusion models for audiovisual sequences allows for a range of generation tasks by learning conditional distributions of various input-output combinations of the two modalities. Nevertheless, this strategy often requires training…

Computer Vision and Pattern Recognition · Computer Science 2025-06-10 Gwanghyun Kim , Alonso Martinez , Yu-Chuan Su , Brendan Jou , José Lezama , Agrim Gupta , Lijun Yu , Lu Jiang , Aren Jansen , Jacob Walker , Krishna Somandepalli

Anomaly detection (AD) plays a pivotal role across diverse domains, including cybersecurity, finance, healthcare, and industrial manufacturing, by identifying unexpected patterns that deviate from established norms in real-world data.…

Machine Learning · Computer Science 2025-06-12 Yang Liu , Jing Liu , Chengfang Li , Rui Xi , Wenchao Li , Liang Cao , Jin Wang , Laurence T. Yang , Junsong Yuan , Wei Zhou

Recently, diffusion models have emerged as a new paradigm for generative models. Despite the success in domains using continuous signals such as vision and audio, adapting diffusion models to natural language is under-explored due to the…

Computation and Language · Computer Science 2023-02-15 Shansan Gong , Mukai Li , Jiangtao Feng , Zhiyong Wu , Lingpeng Kong

The ability to automatically generate music that appropriately matches an arbitrary input track is a challenging task. We present a novel controllable system for generating single stems to accompany musical mixes of arbitrary length. At the…

Sound · Computer Science 2024-02-05 Marco Pasini , Maarten Grachten , Stefan Lattner

Incremental brain tumor segmentation is critical for models that must adapt to evolving clinical datasets without retraining on all prior data. However, catastrophic forgetting, where models lose previously acquired knowledge, remains a…

Image and Video Processing · Electrical Eng. & Systems 2025-10-09 Sashank Makanaboyina

In many real-world regression tasks, the data distribution is heavily skewed, and models learn predominantly from abundant majority samples while failing to predict minority labels accurately. While imbalanced classification has been…

Machine Learning · Computer Science 2025-09-30 Shayan Alahyari