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Designing biological sequences that satisfy multiple, often conflicting, functional and biophysical criteria remains a central challenge in biomolecule engineering. While discrete flow matching models have recently shown promise for…

Machine Learning · Computer Science 2025-05-15 Tong Chen , Yinuo Zhang , Sophia Tang , Pranam Chatterjee

Multiresolution Matrix Factorization (MMF) is unusual amongst fast matrix factorization algorithms in that it does not make a low rank assumption. This makes MMF especially well suited to modeling certain types of graphs with complex…

Machine Learning · Computer Science 2024-08-20 Truong Son Hy , Thieu Khang , Risi Kondor

Modeling real-world distributions can often be challenging due to sample data that are subjected to perturbations, e.g., instrumentation errors, or added random noise. Since flow models are typically nonlinear algorithms, they amplify these…

Machine Learning · Computer Science 2022-10-11 Sameera Ramasinghe , Kasun Fernando , Salman Khan , Nick Barnes

We introduce Flux Matching, a new paradigm for generative modeling that generalizes existing score-based models to a broader family of vector fields that need not be conservative. Rather than requiring the model to equal the data score, the…

Machine Learning · Computer Science 2026-05-11 Peter Pao-Huang , Xiaojie Qiu , Stefano Ermon

We present Functional Mean Flow (FMF) as a one-step generative model defined in infinite-dimensional Hilbert space. FMF extends the one-step Mean Flow framework to functional domains by providing a theoretical formulation for Functional…

Machine Learning · Computer Science 2025-11-18 Zhiqi Li , Yuchen Sun , Greg Turk , Bo Zhu

Modeling stochastic and irregularly sampled time series is a challenging problem found in a wide range of applications, especially in medicine. Neural stochastic differential equations (Neural SDEs) are an attractive modeling technique for…

Machine Learning · Computer Science 2025-02-05 Xi Zhang , Yuan Pu , Yuki Kawamura , Andrew Loza , Yoshua Bengio , Dennis L. Shung , Alexander Tong

Optical flow is a classical task that is important to the vision community. Classical optical flow estimation uses two frames as input, whilst some recent methods consider multiple frames to explicitly model long-range information. The…

Computer Vision and Pattern Recognition · Computer Science 2024-04-09 Qiaole Dong , Yanwei Fu

Deep generative models have recently been applied to physical systems governed by partial differential equations (PDEs), offering scalable simulation and uncertainty-aware inference. However, enforcing physical constraints, such as…

Machine Learning · Computer Science 2025-11-27 Utkarsh Utkarsh , Pengfei Cai , Alan Edelman , Rafael Gomez-Bombarelli , Christopher Vincent Rackauckas

Generative models that can model and predict sequences of future events can, in principle, learn to capture complex real-world phenomena, such as physical interactions. However, a central challenge in video prediction is that the future is…

Computer Vision and Pattern Recognition · Computer Science 2020-02-13 Manoj Kumar , Mohammad Babaeizadeh , Dumitru Erhan , Chelsea Finn , Sergey Levine , Laurent Dinh , Durk Kingma

Variational inference often struggles with the posterior geometry exhibited by complex hierarchical Bayesian models. Recent advances in flow-based variational families and Variationally Inferred Parameters (VIP) each address aspects of this…

Machine Learning · Computer Science 2025-11-06 Joohwan Ko , Justin Domke

Mean-field games (MFGs) study the Nash equilibrium of systems with a continuum of interacting agents, which can be formulated as the fixed-point of optimal control problems. They provide a unified framework for a variety of applications,…

Machine Learning · Statistics 2025-12-02 Jiajia Yu , Junghwan Lee , Yao Xie , Xiuyuan Cheng

We provide a theoretical analysis for end-to-end training Discrete Flow Matching (DFM) generative models. DFM is a promising discrete generative modeling framework that learns the underlying generative dynamics by training a neural network…

Machine Learning · Computer Science 2025-09-29 Maojiang Su , Mingcheng Lu , Jerry Yao-Chieh Hu , Shang Wu , Zhao Song , Alex Reneau , Han Liu

The particle-flow (PF) algorithm is used in general-purpose particle detectors to reconstruct a comprehensive particle-level view of the collision by combining information from different subdetectors. A graph neural network (GNN) model,…

Data Analysis, Statistics and Probability · Physics 2021-11-29 Farouk Mokhtar , Raghav Kansal , Daniel Diaz , Javier Duarte , Joosep Pata , Maurizio Pierini , Jean-Roch Vlimant

We propose \emph{Euler Mean Flows (EMF)}, a flow-based generative framework for one-step and few-step generation that enforces long-range trajectory consistency with minimal sampling cost. The key idea of EMF is to replace the trajectory…

Machine Learning · Computer Science 2026-02-04 Zhiqi Li , Yuchen Sun , Duowen Chen , Jinjin He , Bo Zhu

Classifier-free guidance is a key component for enhancing the performance of conditional generative models across diverse tasks. While it has previously demonstrated remarkable improvements for the sample quality, it has only been…

Machine Learning · Computer Science 2023-12-11 Qinqing Zheng , Matt Le , Neta Shaul , Yaron Lipman , Aditya Grover , Ricky T. Q. Chen

Inferring spatial transcriptomics (ST) from histology enables scalable histogenomic profiling, yet current methods are largely restricted to single-tissue models. This fragmentation fails to leverage biological principles shared across…

Machine Learning · Computer Science 2026-05-13 Susu Hu , Stefanie Speidel

The task of conditional generation is one of the most important applications of generative models, and numerous methods have been developed to date based on the celebrated flow-based models. However, many flow-based models in use today are…

Machine Learning · Computer Science 2024-07-08 Noboru Isobe , Masanori Koyama , Jinzhe Zhang , Kohei Hayashi , Kenji Fukumizu

A machine learning method to predict steady external fluid flows using elliptic input features is introduced. Using data from as few as one high-fidelity simulation, the proposed method produces models generalizable under changes to…

We propose a novel learning framework using neural mean-field (NMF) dynamics for inference and estimation problems on heterogeneous diffusion networks. Our new framework leverages the Mori-Zwanzig formalism to obtain an exact evolution…

Machine Learning · Computer Science 2021-06-07 Shushan He , Hongyuan Zha , Xiaojing Ye

We present Masked Frequency Modeling (MFM), a unified frequency-domain-based approach for self-supervised pre-training of visual models. Instead of randomly inserting mask tokens to the input embeddings in the spatial domain, in this paper,…

Computer Vision and Pattern Recognition · Computer Science 2023-04-26 Jiahao Xie , Wei Li , Xiaohang Zhan , Ziwei Liu , Yew Soon Ong , Chen Change Loy
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