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The study presents a novel approach for quantifying cellular interactions in digital pathology using deep learning-based image cytometry. Traditional methods struggle with the diversity and heterogeneity of cells within tissues. To address…

Quantitative Methods · Quantitative Biology 2024-09-02 Toru Nagasaka , Kimihiro Yamashita , Mitsugu Fujita

We calculate from first principles the O1s core-level shifts for a variety of atomistic models of the interface between TiO2 and the dye N3 found in dye-sensitized solar cells. A systematic comparison between our calculations and published…

Materials Science · Physics 2013-05-29 Christopher E. Patrick , Feliciano Giustino

The statistical properties of intra-chromosome maps obtained by a genome-wide chromosome conformation capture method (Hi-C) are described in the framework of the hierarchical crumpling model of heteropolymer chain with quenched disorder in…

Genomics · Quantitative Biology 2013-12-02 L. Nazarov , M. V. Tamm , S. K. Nechaev , V. A. Avetisov

Motivation: The application of PacBio HiFi and ultra-long ONT reads have achieved huge progress in the contig-level assembly, but it is still challenging to assemble large contigs into chromosomes with available Hi-C scaffolding software,…

Genomics · Quantitative Biology 2021-12-01 Sen Wang , Hengchao Wang , Fan Jiang , Anqi Wang , Hangwei Liu , Hanbo Zhao , Boyuan Yang , Dong Xu , Yan Zhang , Wei Fan

Human-Object Interaction detection is a holistic visual recognition task that entails object detection as well as interaction classification. Previous works of HOI detection has been addressed by the various compositions of subset…

Computer Vision and Pattern Recognition · Computer Science 2022-04-12 Jihwan Park , SeungJun Lee , Hwan Heo , Hyeong Kyu Choi , Hyunwoo J. Kim

Hyperspectral image (HSI) clustering is gaining considerable attention owing to recent methods that overcome the inefficiency and misleading results from the absence of supervised information. Contrastive learning methods excel at existing…

Computer Vision and Pattern Recognition · Computer Science 2023-12-18 Renxiang Guan , Zihao Li , Xianju Li , Chang Tang

Human object interaction (HOI) detection is an important task in image understanding and reasoning. It is in a form of HOI triplet <human; verb; object>, requiring bounding boxes for human and object, and action between them for the task…

Computer Vision and Pattern Recognition · Computer Science 2020-11-13 Suresh Kirthi Kumaraswamy , Miaojing Shi , Ewa Kijak

Human Object Interaction (HOI) detection is a challenging task that requires to distinguish the interaction between a human-object pair. Attention based relation parsing is a popular and effective strategy utilized in HOI. However, current…

Computer Vision and Pattern Recognition · Computer Science 2022-07-19 Jingjia Huang , Baixiang Yang

Motivation: Genomic data analyses such as Genome-Wide Association Studies (GWAS) or Hi-C studies are often faced with the problem of partitioning chromosomes into successive regions based on a similarity matrix of high-resolution,…

Statistics Theory · Mathematics 2019-02-06 Christophe Ambroise , Alia Dehman , Pierre Neuvial , Guillem Rigaill , Nathalie Vialaneix

Human object interaction (HOI) detection plays a crucial role in human-centric scene understanding and serves as a fundamental building-block for many vision tasks. One generalizable and scalable strategy for HOI detection is to use weak…

Computer Vision and Pattern Recognition · Computer Science 2023-03-03 Bo Wan , Yongfei Liu , Desen Zhou , Tinne Tuytelaars , Xuming He

In recent years, the field of single-cell data analysis has seen a marked advancement in the development of clustering methods. Despite advancements, most of these algorithms still concentrate on analyzing the provided single-cell matrix…

Machine Learning · Computer Science 2023-12-18 Dayu Hu , Ke Liang , Hao Yu , Xinwang Liu

Machine learning models are only as good as the data to which they are fit. As such, it is always preferable to use as much data as possible in training models. What data can be used for fitting a model depends a lot on the formulation of…

Computer Vision and Pattern Recognition · Computer Science 2024-06-27 Marwan Zouinkhi , Jeff L. Rhoades , Aubrey V. Weigel

High-content screening uses large collections of unlabeled cell image data to reason about genetics or cell biology. Two important tasks are to identify those cells which bear interesting phenotypes, and to identify sub-populations enriched…

Machine Learning · Computer Science 2015-01-08 Lee Zamparo , Zhaolei Zhang

Unsupervised cell type identification is crucial for uncovering and characterizing heterogeneous populations in single cell omics studies. Although a range of clustering methods have been developed, most focus exclusively on intrinsic…

Artificial Intelligence · Computer Science 2025-12-12 Liang Peng , Haopeng Liu , Yixuan Ye , Cheng Liu , Wenjun Shen , Si Wu , Hau-San Wong

The detection of genomic regions unusually rich in a given pattern is an important undertaking in the analysis of next generation sequencing data. Recent studies of chromosomal translocations in activated B lymphocytes have identified…

Genomics · Quantitative Biology 2022-02-03 Israel T. Silva , Rafael A. Rosales , Adriano J. Holanda , Michel C. Nussenzweig , Mila Jankovic

Publicly available collections of drug-like molecules have grown to comprise 10s of billions of possibilities in recent history due to advances in chemical synthesis. Traditional methods for identifying "hit" molecules from a large…

Motivation: Identifying interaction clusters of large gene regulatory networks (GRNs) is critical for its further investigation, while this task is very challenging, attributed to data noise in experiment data, large scale of GRNs, and…

Machine Learning · Computer Science 2019-10-22 Yu Chen , Yuanyuan Yang , Yaochu Jin , Xiufen Zou

Massive multiple-input multiple-output (MIMO) with frequency division duplex (FDD) mode is a promising approach to increasing system capacity and link robustness for the fifth generation (5G) wireless cellular systems. The premise of these…

Networking and Internet Architecture · Computer Science 2019-07-30 Chaojin Qing , Bin Cai , Qingyao Yang , Jiafan Wang , Chuan Huang

In this article, we show how the recent statistical techniques developed in Topological Data Analysis for the Mapper algorithm can be extended and leveraged to formally define and statistically quantify the presence of topological…

Computational Geometry · Computer Science 2018-12-05 Mathieu Carriere , Raul Rabadan

In multicellular organisms, cells coordinate their activities through cell-cell communication (CCC), which is crucial for development, tissue homeostasis, and disease progression. Recent advances in single-cell and spatial omics…

Quantitative Methods · Quantitative Biology 2026-03-24 Xiangzheng Cheng , Haili Huang , Ye Su , Qing Nie , Xiufen Zou , Suoqin Jin