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Machine Learning Force Fields (MLFFs) are a promising alternative to expensive ab initio quantum mechanical molecular simulations. Given the diversity of chemical spaces that are of interest and the cost of generating new data, it is…

Machine Learning · Computer Science 2025-05-30 Tobias Kreiman , Aditi S. Krishnapriyan

In this paper we present a new machine learning workflow with unsupervised learning techniques to identify domains within atomic force microscopy images obtained from polymer films. The goal of the workflow is to identify the spatial…

Image and Video Processing · Electrical Eng. & Systems 2024-09-23 Aanish Paruchuri , Yunfei Wang , Xiaodan Gu , Arthi Jayaraman

We present a complete set of chemo-structural descriptors to significantly extend the applicability of machine-learning (ML) in material screening and mapping energy landscape for multicomponent systems. These new descriptors allow…

Materials Science · Physics 2018-08-08 Kamal Choudhary , Brian DeCost , Francesca Tavazza

Predicting the adsorption affinity of a small molecule to a target surface is of importance to a range of fields, from catalysis to drug delivery and human safety, but a complex task to perform computationally when taking into account the…

Chemical Physics · Physics 2022-11-16 Ian Rouse , Vladimir Lobaskin

Deploying deep learning models for plant disease detection on edge devices such as IoT sensors, smartphones, and embedded systems is severely constrained by limited computational resources and energy budgets. To address this challenge, we…

Computer Vision and Pattern Recognition · Computer Science 2026-01-27 Weloday Fikadu Moges , Jianmei Su , Amin Waqas

Developing physics-based models for molecular simulation requires fitting many unknown parameters to diverse experimental datasets. Traditionally, this process is piecemeal and difficult to reproduce, leading to a fragmented landscape of…

Biological Physics · Physics 2025-04-10 Ryan K. Krueger , Megan C. Engel , Ryan Hausen , Michael P. Brenner

Machine learning force fields (MLFFs), which employ neural networks to map atomic structures to system energies, effectively combine the high accuracy of first-principles calculation with the computational efficiency of empirical force…

Machine Learning · Computer Science 2025-11-17 Guangyi Dong , Zhihui Wang

We introduce HyperDiffusionFields (HyDiF), a framework that models 3D molecular conformers as continuous fields rather than discrete atomic coordinates or graphs. At the core of our approach is the Molecular Directional Field (MDF), a…

Machine Learning · Computer Science 2025-10-22 Sudarshan Babu , Phillip Lo , Xiao Zhang , Aadi Srivastava , Ali Davariashtiyani , Jason Perera , Michael Maire , Aly A. Khan

The increasing number of protein-based metamaterials demands reliable and efficient theoretical and computational methods to study the physicochemical properties they may display. In this regard, we develop a simulation strategy based on…

Soft Condensed Matter · Physics 2020-06-23 J. A. Campos Gonzalez Angulo , G. Wiesehan , R. F. Ribeiro , J. Yuen-Zhou

Atomic force microscopy (AFM) is a key tool for characterising nanoscale structures, with functionalised tips now offering detailed images of the atomic structure. In parallel, AFM simulations using the particle probe model provide a…

Materials Science · Physics 2025-09-03 Jie Huang , Niko Oinonen , Fabio Priante , Filippo Federici Canova , Lauri Kurki , Chen Xu , Adam S. Foster

This study employed an artificial intelligence-enhanced molecular simulation framework to enable efficient Path Integral Molecular Dynamics (PIMD) simulations. Owing to its modular architecture and high-throughput capabilities, the…

Chemical Physics · Physics 2025-04-01 Cheng Fan , Maodong Li , Sihao Yuan , Zhaoxin Xie , Dechin Chen , Yi Isaac Yang , Yi Qin Gao

We present a Data-Driven (DD) paradigm that enables molecular dynamics calculations to be performed directly from sampled force-field data such as obtained, e.g., from ab initio calculations, thereby eschewing the conventional step of…

Chemical Physics · Physics 2022-08-11 J. Bulin , J. Hamaekers , M. P. Ariza , M. Ortiz

Transition Metal Complexes (TMCs) have wide-ranging practical utility in chemistry, with possible applications that range from catalysis to medicinal chemistry. The study of TMCs and their properties is thus a field rich with potential, one…

Chemical Physics · Physics 2026-02-10 Luca Cibinel , Trond Linjordet , Johan Pensar , David Balcells , Riccardo De Bin , Basil Ell

Atomic force microscopy (AFM) is one of the most promising methods for investigating the structure of materials at the micro and nanoscale levels, as well as their local physical-mechanical properties. The experimental data obtained with…

Materials Science · Physics 2018-05-07 Oleg K. Garishin , Roman I. Izyumov , Alexander L. Svistkov

Forming a molecular candidate set that contains a wide range of potentially effective compounds is crucial to the success of drug discovery. While most databases and machine-learning-based generation models aim to optimize particular…

Computational Engineering, Finance, and Science · Computer Science 2023-03-08 Yutong Xie , Ziqiao Xu , Jiaqi Ma , Qiaozhu Mei

Deep neural networks (DNNs) have been used to successfully predict molecular properties calculated based on the Kohn--Sham density functional theory (KS-DFT). Although this prediction is fast and accurate, we believe that a DNN model for…

Chemical Physics · Physics 2020-11-17 Masashi Tsubaki , Teruyasu Mizoguchi

Density Functional Tight Binding (DFTB) is an attractive method for accelerated quantum simulations of condensed matter due to its enhanced computational efficiency over standard Density Functional Theory approaches. However, DFTB models…

Extreme mechanical processes such as strong lattice distortion and bond breakage during fracture are ubiquitous in nature and engineering, which often lead to catastrophic failure of structures. However, understanding the nucleation and…

Materials Science · Physics 2024-07-23 Pengjie Shi , Zhiping Xu

Computational chemistry has become an indispensable tool for generating data and insights, pervading all branches of experimental chemistry. Its most central concept is the potential energy hypersurface, key to all chemistry and materials…

Chemical Physics · Physics 2026-04-03 Raphael T. Husistein , Markus Reiher

The atomic force microscope (AFM) is a versatile, high-resolution tool used to characterize the topography and material properties of a large variety of specimens at nano-scale. The interaction of the micro-cantilever tip with the specimen…

Materials Science · Physics 2011-09-05 David Busch , Qingze Zou , Baskar Ganapathysubramanian