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A broad range of scientific and industrial disciplines require precise optical measurements at very low light levels. Single-photon detectors combining high efficiency and high time resolution are pivotal in such experiments. By using…

Diffraction-before-destruction imaging with single ultrashort X-ray pulses has the potential to visualise non-equilibrium processes, such as chemical reactions, at the nanoscale with sub-femtosecond resolution in the native environment…

Fundamental understanding of biological pathways requires minimally invasive nanoscopic optical resolution imaging. Many approaches to high-resolution imaging rely on localization of single emitters, such as fluorescent molecule or quantum…

Quantum Physics · Physics 2022-04-05 Shuo Li , Wenchao Li , Vladislav V. Yakovlev , Allison Kealy , Andrew D. Greentree

Common methods to achieve photon number resolution rely on fast on-off single-photon detectors in conjunction with temporal or spatial mode multiplexing. Yet, these methods suffer from an inherent trade-off between the efficiency of photon…

Quantum Physics · Physics 2024-11-21 Anton N. Vetlugin , Filippo Martinelli , Shuyu Dong , Cesare Soci

When x-rays penetrate soft matter, their phase changes more rapidly than their amplitude. In- terference effects visible with high brightness sources creates higher contrast, edge enhanced images. When the object is piecewise smooth (made…

X-ray phase-contrast imaging (XPCI) is a versatile technique with wide-ranging applications, particularly in the fields of biology and medicine. Where X-ray absorption radiography requires high density ratios for effective imaging, XPCI is…

Optical detection of nanoscale objects without relying on fluorescence is a current challenge due to their extremely weak interaction with light. Resonator-enhanced absorption microscopy is a novel tool to heavily boost the light-matter…

Small-angle X-ray scattering (SAXS) technique enables convenient nanoscopic characterization for various systems and conditions. Nonetheless, lab-based SAXS systems intrinsically suffer from insufficient x-ray flux and limited angular…

Instrumentation and Detectors · Physics 2020-09-30 Benjamin Gutman , Michael Mrejen , Gil Shabat , Ram Avinery , Yoel Shkolnisky , Roy Beck

This paper describes the development of a novel medical Xray imaging system adapted to the needs and constraints of low and middle income countries. The developed system is based on an indirect conversion chain: a scintillator plate…

A number of applications in basic science and technology would benefit from high fidelity photon number resolving photodetectors. While some recent experimental progress has been made in this direction, the requirements for true photon…

Quantum Physics · Physics 2020-05-21 Steve M. Young , Mohan Sarovar , François Léonard

The phosphor nanoparticles made of doped semiconductors, pre-excited by well-collimated X-ray radiation, were recently reported for their light emission upon NIR light stimulation. The characteristics of X-ray energy storage and NIR…

Biological Physics · Physics 2015-06-17 Wenxiang Cong , Chao Wang , Ge Wang

We present a structured-illumination technique for full-field super-resolution transmission X-ray microscopy, which employs Fourier spectral decomposition inspired by established methods in visible-light microscopy. A 2D grating creating…

The problem of optimization of propagation-based phase-contrast imaging setups is considered in the case of projection X-ray imaging and three-dimensional tomography with phase retrieval. For two-dimensional imaging, a simple model for a…

Medical Physics · Physics 2026-03-03 T. E. Gureyev , D. M. Paganin , H. M. Quiney

Structural studies of biological macromolecules are severely limited by radiation damage. Traditional crystallography curbs the effects of damage by spreading damage over many copies of the molecule of interest. X-ray lasers, such as the…

Motion management is a critical component of image guidance radiotherapy for lung cancer. We previously proposed a scheme using kV scattered x-ray photons for marker-less real-time image guidance in lung cancer radiotherapy. This study…

Medical Physics · Physics 2020-09-11 Yanqi Huang , Kai Yang , Youfang Lai , Huan Liu , Chenyang Shen , Yuncheng Zhong , Yiping Shao , Xinhua Li , Bob Liu , Xun Jia

Superconducting resonators have to date been used for photon detection in a non-equilibrium manner. In this paper, we demonstrate that such devices can also be used in a thermal quasi-equilibrium manner to detect X-ray photons. We have used…

Superconductivity · Physics 2015-06-15 Orlando Quaranta , Thomas Cecil , Lisa Gades , Benjamin Mazin , Antonino Miceli

The performance of hybrid GaAs pixel detectors as X-ray imaging sensors were investigated at room temperature. These hybrids consist of 300 mu-m thick GaAs pixel detectors, flip-chip bonded to a CMOS Single Photon Counting Chip (PCC). This…

We lay the foundations for a new fast method to reconstruct the electron density in x-ray scanning applications using measurements in the dark field. This approach is applied to a type of machine configuration with fixed energy sensitive…

Numerical Analysis · Mathematics 2015-05-08 James Webber

Scintillators convert ionizing radiation into visible photons, enabling applications from cosmic ray detection to medical imaging. Two independent strategies for improving scintillator performance via nanoscale patterning have recently been…

Progress in high-resolution x-ray microtomography has provided us with a practical approach to determining three-dimensional (3D) structures of opaque samples at micrometer to submicrometer resolution. In this review, we give an…

Biological Physics · Physics 2016-09-09 Ryuta Mizutani , Yoshio Suzuki
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