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Uncertainty Quantification (UQ) is pivotal in enhancing the robustness, reliability, and interpretability of Machine Learning (ML) systems for healthcare, optimizing resources and improving patient care. Despite the emergence of ML-based…

Machine Learning · Computer Science 2025-05-07 L. Julián Lechuga López , Shaza Elsharief , Dhiyaa Al Jorf , Firas Darwish , Congbo Ma , Farah E. Shamout

Assessing response quality to instructions in language models is vital but challenging due to the complexity of human language across different contexts. This complexity often results in ambiguous or inconsistent interpretations, making…

This paper explores uncertainty quantification (UQ) as an indicator of the trustworthiness of automated deep-learning (DL) tools in the context of white matter lesion (WML) segmentation from magnetic resonance imaging (MRI) scans of…

Uncertainty calibration is essential for the safe deployment of large language models (LLMs), particularly when users rely on verbalized confidence estimates. While prior work has focused on classifiers or short-form generation, confidence…

Computation and Language · Computer Science 2025-06-05 Chaeyun Jang , Moonseok Choi , Yegon Kim , Hyungi Lee , Juho Lee

Neural networks (NNs) are currently changing the computational paradigm on how to combine data with mathematical laws in physics and engineering in a profound way, tackling challenging inverse and ill-posed problems not solvable with…

Machine Learning · Computer Science 2023-02-08 Apostolos F Psaros , Xuhui Meng , Zongren Zou , Ling Guo , George Em Karniadakis

Machine learning (ML) offers promising new approaches to tackle complex problems and has been increasingly adopted in chemical and materials sciences. Broadly speaking, ML models employ generic mathematical functions and attempt to learn…

Materials Science · Physics 2024-08-21 Jin Dai , Santosh Adhikari , Mingjian Wen

In recent years, Large Language Models (LLMs) have become fundamental to a broad spectrum of artificial intelligence applications. As the use of LLMs expands, precisely estimating the uncertainty in their predictions has become crucial.…

Artificial Intelligence · Computer Science 2024-10-29 Mohammad Beigi , Sijia Wang , Ying Shen , Zihao Lin , Adithya Kulkarni , Jianfeng He , Feng Chen , Ming Jin , Jin-Hee Cho , Dawei Zhou , Chang-Tien Lu , Lifu Huang

When using large language models (LLMs) in high-stakes applications, we need to know when we can trust their predictions. Some works argue that prompting high-performance LLMs is sufficient to produce calibrated uncertainties, while others…

Uncertainty quantification (UQ) is essential for assessing the reliability of Earth observation (EO) products. However, the extensive use of machine learning models in EO introduces an additional layer of complexity, as those models…

Machine Learning · Computer Science 2024-12-10 Yuanyuan Wang , Qian Song , Dawood Wasif , Muhammad Shahzad , Christoph Koller , Jonathan Bamber , Xiao Xiang Zhu

Large language models (LLMs) are increasingly employed in information-seeking and decision-making tasks. Despite their broad utility, LLMs tend to generate information that conflicts with real-world facts, and their persuasive style can…

Computation and Language · Computer Science 2024-09-19 Arslan Chaudhry , Sridhar Thiagarajan , Dilan Gorur

In this paper we motivate the causal mechanisms behind sample selection induced collider bias (selection collider bias) that can cause Large Language Models (LLMs) to learn unconditional dependence between entities that are unconditionally…

Computation and Language · Computer Science 2022-09-14 Emily McMilin

In an educational setting, an estimate of the difficulty of multiple-choice questions (MCQs), a commonly used strategy to assess learning progress, constitutes very useful information for both teachers and students. Since human assessment…

Computation and Language · Computer Science 2025-04-21 Leonidas Zotos , Hedderik van Rijn , Malvina Nissim

The recent performance leap of Large Language Models (LLMs) opens up new opportunities across numerous industrial applications and domains. However, erroneous generations, such as false predictions, misinformation, and hallucination made by…

Software Engineering · Computer Science 2025-01-07 Yuheng Huang , Jiayang Song , Zhijie Wang , Shengming Zhao , Huaming Chen , Felix Juefei-Xu , Lei Ma

Unlearning in large language models (LLMs) aims to remove harmful training data while preserving overall utility. However, we find that existing methods often hallucinate, generate abnormal token sequences, or behave inconsistently, raising…

Machine Learning · Computer Science 2026-05-12 Renjie Gu , Jiazhen Du , Yihua Zhang , Sijia Liu

Retrieval-Augmented Generation (RAG) has emerged as a widely adopted approach for enhancing LLMs in scenarios that demand extensive factual knowledge. However, current RAG evaluations concentrate primarily on correctness, which may not…

Computation and Language · Computer Science 2026-03-23 Vinh Nguyen , Cuong Dang , Jiahao Zhang , Hoa Tran , Minh Tran , Trinh Chau , Thai Le , Lu Cheng , Suhang Wang

While neural networks have demonstrated impressive performance across various tasks, accurately quantifying uncertainty in their predictions is essential to ensure their trustworthiness and enable widespread adoption in critical systems.…

Machine Learning · Statistics 2025-11-11 Joseph Wilson , Chris van der Heide , Liam Hodgkinson , Fred Roosta

It is critical that machine learning (ML) model predictions be trustworthy for high-throughput catalyst discovery approaches. Uncertainty quantification (UQ) methods allow estimation of the trustworthiness of an ML model, but these methods…

Machine Learning · Computer Science 2023-02-07 Cameron Gruich , Varun Madhavan , Yixin Wang , Bryan Goldsmith

Large language models (LLMs) are prone to generating factually incorrect outputs. Recent work has applied conformal prediction to provide uncertainty estimates and statistical guarantees for the factuality of LLM generations. However,…

Computation and Language · Computer Science 2026-04-16 Aleksandr Rubashevskii , Dzianis Piatrashyn , Preslav Nakov , Maxim Panov

Large Language Models~(LLMs) are prone to hallucinations, and Retrieval-Augmented Generation (RAG) helps mitigate this, but at a high computational cost while risking misinformation. Adaptive retrieval aims to retrieve only when necessary,…

Large language models (LLMs) could be valuable personal AI agents across various domains, provided they can precisely follow user instructions. However, recent studies have shown significant limitations in LLMs' instruction-following…

Artificial Intelligence · Computer Science 2025-03-31 Juyeon Heo , Miao Xiong , Christina Heinze-Deml , Jaya Narain
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