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Graphs with abundant attributes are essential in modeling interconnected entities and enhancing predictions across various real-world applications. Traditional Graph Neural Networks (GNNs) often require re-training for different graph tasks…

Computation and Language · Computer Science 2026-05-26 Yanchao Tan , Hang Lv , Pengxiang Zhan , Shiping Wang , Carl Yang

Predicting molecular properties with data-driven methods has drawn much attention in recent years. Particularly, Graph Neural Networks (GNNs) have demonstrated remarkable success in various molecular generation and prediction tasks. In…

Quantitative Methods · Quantitative Biology 2021-10-19 Zaixi Zhang , Qi Liu , Hao Wang , Chengqiang Lu , Chee-Kong Lee

The industry and academia have proposed many distributed graph processing systems. However, the existing systems are not friendly enough for users like data analysts and algorithm engineers. On the one hand, the programing models and…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-08-05 Zhaokang Wang , Junhong Li , Yifan Qi , Guanghui Zhu , Chunfeng Yuan , Yihua Huang

Molecular generation plays an important role in drug discovery and materials science, especially in data-scarce scenarios where traditional generative models often struggle to achieve satisfactory conditional generalization. To address this…

Machine Learning · Computer Science 2025-05-13 Zimo Yan , Jie Zhang , Zheng Xie , Chang Liu , Yizhen Liu , Yiping Song

Recent advances in machine learning for molecules exhibit great potential for facilitating drug discovery from in silico predictions. Most models for molecule generation rely on the decomposition of molecules into frequently occurring…

Chemical Physics · Physics 2023-11-08 Leon Hetzel , Johanna Sommer , Bastian Rieck , Fabian Theis , Stephan Günnemann

Controllable molecular graph generation is essential for material and drug discovery, where generated molecules must satisfy diverse property constraints. While recent advances in graph diffusion models have improved generation quality,…

Machine Learning · Computer Science 2025-09-30 Anjie Qiao , Zhen Wang , Chuan Chen , DeFu Lian , Enhong Chen

We tackle the common challenge of inter-concept visual confusion in compositional concept generation using text-guided diffusion models (TGDMs). It becomes even more pronounced in the generation of customized concepts, due to the scarcity…

Computer Vision and Pattern Recognition · Computer Science 2024-05-14 Wang Lin , Jingyuan Chen , Jiaxin Shi , Yichen Zhu , Chen Liang , Junzhong Miao , Tao Jin , Zhou Zhao , Fei Wu , Shuicheng Yan , Hanwang Zhang

Well-designed prompts have demonstrated the potential to guide text-to-image models in generating amazing images. Although existing prompt engineering methods can provide high-level guidance, it is challenging for novice users to achieve…

Multimedia · Computer Science 2026-03-27 Nailei Hei , Qianyu Guo , Zihao Wang , Yan Wang , Haofen Wang , Wenqiang Zhang

Sign language transition generation seeks to convert discrete sign language segments into continuous sign videos by synthesizing smooth transitions. However,most existing methods merely concatenate isolated signs, resulting in poor visual…

Computer Vision and Pattern Recognition · Computer Science 2025-06-17 Jiashu He , Jiayi He , Shengeng Tang , Huixia Ben , Lechao Cheng , Richang Hong

We propose a hierarchical normalizing flow model for generating molecular graphs. The model produces new molecular structures from a single-node graph by recursively splitting every node into two. All operations are invertible and can be…

Chemical Physics · Physics 2021-06-11 Maksim Kuznetsov , Daniil Polykovskiy

Text-to-Image (T2I) diffusion models have shown impressive results in generating visually compelling images following user prompts. Building on this, various methods further fine-tune the pre-trained T2I model for specific tasks. However,…

Computer Vision and Pattern Recognition · Computer Science 2025-04-24 Tsu-Jui Fu , Yusu Qian , Chen Chen , Wenze Hu , Zhe Gan , Yinfei Yang

Recent advances in generative diffusion models have enabled text-controlled synthesis of realistic and diverse images with impressive quality. Despite these remarkable advances, the application of text-to-image generative models in computer…

Computer Vision and Pattern Recognition · Computer Science 2024-03-19 Yulu Gan , Sungwoo Park , Alexander Schubert , Anthony Philippakis , Ahmed M. Alaa

Graph generation techniques are increasingly being adopted for drug discovery. Previous graph generation approaches have utilized relatively small molecular building blocks such as atoms or simple cycles, limiting their effectiveness to…

Machine Learning · Computer Science 2020-04-21 Wengong Jin , Regina Barzilay , Tommi Jaakkola

Designing protein sequences with specific biological functions and structural stability is crucial in biology and chemistry. Generative models already demonstrated their capabilities for reliable protein design. However, previous models are…

Machine Learning · Computer Science 2024-02-28 Lin Zongying , Li Hao , Lv Liuzhenghao , Lin Bin , Zhang Junwu , Chen Calvin Yu-Chian , Yuan Li , Tian Yonghong

Existing text-to-image diffusion models primarily generate images from text prompts. However, the inherent conciseness of textual descriptions poses challenges in faithfully synthesizing images with intricate details, such as specific…

Computer Vision and Pattern Recognition · Computer Science 2024-06-07 Wei Li , Xue Xu , Jiachen Liu , Xinyan Xiao

Text-conditioned molecular generation aims to translate natural-language descriptions into chemical structures, enabling scientists to specify functional groups, scaffolds, and physicochemical constraints without handcrafted rules.…

Machine Learning · Computer Science 2025-11-18 Lingxiao Li , Haobo Zhang , Bin Chen , Jiayu Zhou

Removing various degradations from damaged documents greatly benefits digitization, downstream document analysis, and readability. Previous methods often treat each restoration task independently with dedicated models, leading to a…

Computer Vision and Pattern Recognition · Computer Science 2025-08-07 Fangmin Zhao , Weichao Zeng , Zhenhang Li , Dongbao Yang , Binbin Li , Xiaojun Bi , Yu Zhou

Inverse molecular design with diffusion models holds great potential for advancements in material and drug discovery. Despite success in unconditional molecular generation, integrating multiple properties such as synthetic score and gas…

Machine Learning · Computer Science 2024-10-04 Gang Liu , Jiaxin Xu , Tengfei Luo , Meng Jiang

Molecular dynamics is a powerful simulation tool to explore material properties. Most of the realistic material systems are too large to be simulated with first-principles molecular dynamics. Classical molecular dynamics has lower…

Computational Physics · Physics 2021-01-11 Zun Wang , Chong Wang , Sibo Zhao , Shiqiao Du , Yong Xu , Bing-Lin Gu , Wenhui Duan

Diffusion models have shown great promise in data generation, yet generating time series data remains challenging due to the need to capture complex temporal dependencies and structural patterns. In this paper, we present \textit{TSGDiff},…

Machine Learning · Computer Science 2025-11-18 Lifeng Shen , Xuyang Li , Lele Long