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Automated white blood cell (WBC) classification is essential for leukemia screening but remains challenged by extreme class imbalance, long-tail distributions, and domain shift, leading deep models to overfit dominant classes and fail on…

Computer Vision and Pattern Recognition · Computer Science 2026-03-31 Duc T. Nguyen , Hoang-Long Nguyen , Huy-Hieu Pham

Image classification is a well-studied task in computer vision, and yet it remains challenging under high-uncertainty conditions, such as when input images are corrupted or training data are limited. Conventional classification approaches…

Computer Vision and Pattern Recognition · Computer Science 2025-11-26 Omer Belhasin , Shelly Golan , Ran El-Yaniv , Michael Elad

Digital pathology has advanced significantly over the last decade, with Whole Slide Images (WSIs) encompassing vast amounts of data essential for accurate disease diagnosis. High-resolution WSIs are essential for precise diagnosis but…

Image and Video Processing · Electrical Eng. & Systems 2024-08-28 Xuan Xu , Saarthak Kapse , Prateek Prasanna

Accurate morphological classification of white blood cells (WBCs) is an important step in the diagnosis of leukemia, a disease in which nonfunctional blast cells accumulate in the bone marrow. Recently, deep convolutional neural networks…

Computer Vision and Pattern Recognition · Computer Science 2023-04-19 Rao Muhammad Umer , Armin Gruber , Sayedali Shetab Boushehri , Christian Metak , Carsten Marr

Nuclei segmentation and classification is a significant process in pathology image analysis. Deep learning-based approaches have greatly contributed to the higher accuracy of this task. However, those approaches suffer from the imbalanced…

Computer Vision and Pattern Recognition · Computer Science 2023-06-27 Hyun-Jic Oh , Won-Ki Jeong

Recent advances in Diffusion Probabilistic Models (DPMs) have set new standards in high-quality image synthesis. Yet, controlled generation remains challenging, particularly in sensitive areas such as medical imaging. Medical images feature…

Computer Vision and Pattern Recognition · Computer Science 2025-10-09 Sarah Cechnicka , Matthew Baugh , Weitong Zhang , Mischa Dombrowski , Zhe Li , Johannes C. Paetzold , Candice Roufosse , Bernhard Kainz

Medical image segmentation models struggle with rare abnormalities due to scarce annotated pathological data. We propose DiffAug a novel framework that combines textguided diffusion-based generation with automatic segmentation validation to…

Computer Vision and Pattern Recognition · Computer Science 2025-08-26 Maham Nazir , Muhammad Aqeel , Francesco Setti

Bone marrow cytology is required to make a hematological diagnosis, influencing critical clinical decision points in hematology. However, bone marrow cytology is tedious, limited to experienced reference centers and associated with high…

Image and Video Processing · Electrical Eng. & Systems 2021-07-09 Rohollah Moosavi Tayebi , Youqing Mu , Taher Dehkharghanian , Catherine Ross , Monalisa Sur , Ronan Foley , Hamid R. Tizhoosh , Clinton JV Campbell

Swift and accurate blood smear analysis is an effective diagnostic method for leukemia and other hematological malignancies. However, manual leukocyte count and morphological evaluation using a microscope is time-consuming and prone to…

Computer Vision and Pattern Recognition · Computer Science 2024-10-22 Chandravardhan Singh Raghaw , Arnav Sharma , Shubhi Bansal , Mohammad Zia Ur Rehman , Nagendra Kumar

We present a foundation modeling framework that leverages deep learning to uncover latent genetic signatures across the hematopoietic hierarchy. Our approach trains a fully connected autoencoder on multipotent progenitor cells, reducing…

Machine Learning · Computer Science 2025-03-27 Gabriel Bo , Justin Gu , Christopher Sun

Diffusion models are a special type of generative model, capable of synthesising new data from a learnt distribution. We introduce DISPR, a diffusion-based model for solving the inverse problem of three-dimensional (3D) cell shape…

Computer Vision and Pattern Recognition · Computer Science 2023-03-15 Dominik J. E. Waibel , Ernst Röell , Bastian Rieck , Raja Giryes , Carsten Marr

In medical imaging, the diffusion models have shown great potential for synthetic image generation tasks. However, these approaches often lack the interpretable connections between the generated and real images and can create anatomically…

Image and Video Processing · Electrical Eng. & Systems 2026-02-12 Jian-Qing Zheng , Yuanhan Mo , Yang Sun , Jiahua Li , Fuping Wu , Ziyang Wang , Tonia Vincent , Bartłomiej W. Papież

Histology imaging is an essential diagnosis method to finalize the grade and stage of cancer of different tissues, especially for breast cancer diagnosis. Specialists often disagree on the final diagnosis on biopsy tissue due to the complex…

Computer Vision and Pattern Recognition · Computer Science 2019-09-17 Yongxiang Huang , Albert Chi-shing Chung

Graph generation is a critical yet challenging task, as empirical analyses require a deep understanding of complex, non-Euclidean structures. Diffusion models have recently made significant advances in graph generation, but these models are…

Machine Learning · Computer Science 2026-03-13 Yiming Huang , Tolga Birdal

Deep learning is widely applied in computer-aided pathological diagnosis, which alleviates the pathologist workload and provide timely clinical analysis. However, most models generally require large-scale annotated data for training, which…

Computer Vision and Pattern Recognition · Computer Science 2024-03-12 Zeyu Liu , Tianyi Zhang , Yufang He , Yunlu Feng , Yu Zhao , Guanglei Zhang

The accurate classification of white blood cells and related blood components is crucial for medical diagnoses. While traditional manual examinations and automated hematology analyzers have been widely used, they are often slow and prone to…

Image and Video Processing · Electrical Eng. & Systems 2024-07-02 Alexander Kim , Ryan Kim

Blood cell classification and counting are vital for the diagnosis of various blood-related diseases, such as anemia, leukemia, and thrombocytopenia. The manual process of blood cell classification and counting is time-consuming, prone to…

Image and Video Processing · Electrical Eng. & Systems 2024-05-27 Sohag Kumar Mondal , Md. Simul Hasan Talukder , Mohammad Aljaidi , Rejwan Bin Sulaiman , Md Mohiuddin Sarker Tushar , Amjad A Alsuwaylimi

Deep learning models have made significant advances in histological prediction tasks in recent years. However, for adaptation in clinical practice, their lack of robustness to varying conditions such as staining, scanner, hospital, and…

Image and Video Processing · Electrical Eng. & Systems 2025-06-23 David Jacob Drexlin , Jonas Dippel , Julius Hense , Niklas Prenißl , Grégoire Montavon , Frederick Klauschen , Klaus-Robert Müller

Medical professionals, especially those in training, often depend on visual reference materials to support an accurate diagnosis and develop pattern recognition skills. However, existing resources may lack the diversity and accessibility…

Computer Vision and Pattern Recognition · Computer Science 2025-06-03 Kanishk Choudhary

The diagnosis of blood-based diseases often involves identifying and characterizing patient blood samples. Automated methods to detect and classify blood cell subtypes have important medical applications. Automated medical image processing…

Computer Vision and Pattern Recognition · Computer Science 2021-06-24 Sai Sukruth Bezugam