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Self-supervised learning (SSL) has proven to be a powerful approach for extracting biologically meaningful representations from single-cell data. To advance our understanding of SSL methods applied to single-cell data, we present…

Quantitative Methods · Quantitative Biology 2025-06-13 Olga Ovcharenko , Florian Barkmann , Philip Toma , Imant Daunhawer , Julia Vogt , Sebastian Schelter , Valentina Boeva

Single-cell RNA sequencing (scRNA-seq) has made significant strides in unraveling the intricate cellular diversity within complex tissues. This is particularly critical in the brain, presenting a greater diversity of cell types than other…

Machine Learning · Computer Science 2023-10-05 Gyutaek Oh , Baekgyu Choi , Inkyung Jung , Jong Chul Ye

Recent advancements in single-cell genomics necessitate precision in gene panel selection to interpret complex biological data effectively. Those methods aim to streamline the analysis of scRNA-seq data by focusing on the most informative…

Artificial Intelligence · Computer Science 2024-06-12 Weiliang Zhang , Zhen Meng , Dongjie Wang , Min Wu , Kunpeng Liu , Yuanchun Zhou , Meng Xiao

Graph clustering, which learns the node representations for effective cluster assignments, is a fundamental yet challenging task in data analysis and has received considerable attention accompanied by graph neural networks in recent years.…

Machine Learning · Computer Science 2023-09-12 Si-Yu Yi , Wei Ju , Yifang Qin , Xiao Luo , Luchen Liu , Yong-Dao Zhou , Ming Zhang

Spectral clustering is a leading clustering method. Two of its major shortcomings are the disjoint optimization process and the limited representation capacity. To address these issues, we propose a deep spectral clustering model (named…

Computer Vision and Pattern Recognition · Computer Science 2025-08-07 Wengang Guo , Wei Ye , Chunchun Chen , Xin Sun , Christian Böhm , Claudia Plant , Susanto Rahardja

Change detection, which aims to distinguish surface changes based on bi-temporal images, plays a vital role in ecological protection and urban planning. Since high resolution (HR) images cannot be typically acquired continuously over time,…

Image and Video Processing · Electrical Eng. & Systems 2021-06-24 Mengxi Liu , Qian Shi , Andrea Marinoni , Da He , Xiaoping Liu , Liangpei Zhang

Spatial transcriptomics clustering is pivotal for identifying cell subpopulations by leveraging spatial location information. While recent graph-based methods modeling cell-cell interactions have improved clustering accuracy, they remain…

Machine Learning · Computer Science 2026-01-21 Chenkai Guo , Yikai Zhu , Renxiang Guan , Jinli Ma , Siwei Wang , Ke Liang , Guangdun Peng , Dayu Hu

Many complex systems in the real world can be characterized by attributed networks. To mine the potential information in these networks, deep embedded clustering, which obtains node representations and clusters simultaneously, has been paid…

Machine Learning · Computer Science 2022-05-31 Yimei Zheng , Caiyan Jia , Jian Yu , Xuanya Li

Recent advances in high-resolution sequencing have paved the way for population-scale analysis in single-cell RNA-sequencing (scRNA-seq) data. scRNA-seq data, in particular, have proven to be extremely powerful in profiling a variety of…

Methodology · Statistics 2025-10-30 Hanxuan Ye , Zachary Qian , Hongzhe Li

Graph convolutional network (GCN) is a powerful model studied broadly in various graph structural data learning tasks. However, to mitigate the over-smoothing phenomenon, and deal with heterogeneous graph structural data, the design of GCN…

Machine Learning · Statistics 2024-12-12 Jia Cai , Zhilong Xiong , Shaogao Lv

Single-cell RNA sequencing (scRNA-seq) has revealed complex cellular heterogeneity, but recent studies emphasize that understanding biological function also requires modeling cell-cell communication (CCC), the signaling interactions…

Machine Learning · Computer Science 2025-12-29 Cong Qi , Yeqing Chen , Zhi Wei

ASD is a complicated neurodevelopmental disorder marked by variation in symptom presentation and neurological underpinnings, making early and objective diagnosis extremely problematic. This paper presents a Graph Convolutional Network (GCN)…

Computer Vision and Pattern Recognition · Computer Science 2025-12-01 Adnan Ferdous Ashrafi , Hasanul Kabir

Background: Single-cell RNA sequencing (scRNA-seq) is a powerful profiling technique at the single-cell resolution. Appropriate analysis of scRNA-seq data can characterize molecular heterogeneity and shed light into the underlying cellular…

Applications · Statistics 2019-08-05 Siamak Zamani Dadaneh , Paul de Figueiredo , Sing-Hoi Sze , Mingyuan Zhou , Xiaoning Qian

Repetitive DNA (repeats) poses significant challenges for accurate and efficient genome assembly and sequence alignment. This is particularly true for metagenomic data, where genome dynamics such as horizontal gene transfer, gene…

Machine Learning · Computer Science 2024-02-15 Ali Azizpour , Advait Balaji , Todd J. Treangen , Santiago Segarra

The exploration of cellular heterogeneity within the tumor microenvironment (TME) via single-cell RNA sequencing (scRNA-seq) is essential for understanding cancer progression and response to therapy. Current scRNA-seq approaches, however,…

Genomics · Quantitative Biology 2025-02-06 Yu-An Huang , Yue-Chao Li , Hai-Ru You , Jie Pan , Xiyue Cao , Xinyuan Li , Zhi-An Huang , Zhu-Hong You

Rapid advancements in high-throughput single-cell RNA-seq (scRNA-seq) technologies and experimental protocols have led to the generation of vast amounts of genomic data that populates several online databases and repositories. Here, we…

Genomics · Quantitative Biology 2024-04-17 Mahnoor N. Gondal , Saad Ur Rehman Shah , Arul M. Chinnaiyan , Marcin Cieslik

The high dimensional and semantically complex nature of textual Big data presents significant challenges for text clustering, which frequently lead to suboptimal groupings when using conventional techniques like k-means or hierarchical…

Computation and Language · Computer Science 2025-08-25 Mohammad Wali Ur Rahman , Ric Nevarez , Lamia Tasnim Mim , Salim Hariri

Recent advances in technology have enabled the measurement of RNA levels for individual cells. Compared to traditional tissue-level bulk RNA-seq data, single cell sequencing yields valuable insights about gene expression profiles for…

Applications · Statistics 2019-04-16 Lingxue Zhu , Jing Lei , Bernie Devlin , Kathryn Roeder

Single-cell RNA sequencing (scRNA-seq) provides a high throughput, quantitative and unbiased framework for scientists in many research fields to identify and characterize cell types within heterogeneous cell populations from various…

Quantitative Methods · Quantitative Biology 2022-09-28 Yeganeh Madadi , Aboozar Monavarfeshani , Hao Chen , W. Daniel Stamer , Robert W. Williams , Siamak Yousefi

Channel pruning is a powerful technique to reduce the computational overhead of deep neural networks, enabling efficient deployment on resource-constrained devices. However, existing pruning methods often rely on local heuristics or…

Artificial Intelligence · Computer Science 2025-06-16 Zifan Liu , Yuan Cao , Yanwei Yu , Heng Qi , Jie Gui
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