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Conventional and deep learning-based methods have shown great potential in the medical imaging domain, as means for deriving diagnostic, prognostic, and predictive biomarkers, and by contributing to precision medicine. However, these…

Regularization-based image restoration has remained an active research topic in computer vision and image processing. It often leverages a guidance signal captured in different fields as an additional cue. In this work, we present a general…

Computer Vision and Pattern Recognition · Computer Science 2016-12-21 Youngjung Kim , Hyungjoo Jung , Dongbo Min , Kwanghoon Sohn

The Segment Anything Model (SAM) has achieved remarkable successes in the realm of natural image segmentation, but its deployment in the medical imaging sphere has encountered challenges. Specifically, the model struggles with medical…

Computer Vision and Pattern Recognition · Computer Science 2024-08-02 Shreyank N Gowda , David A. Clifton

The Sharpness Aware Minimization (SAM) optimization algorithm has been shown to control large eigenvalues of the loss Hessian and provide generalization benefits in a variety of settings. The original motivation for SAM was a modified loss…

Machine Learning · Computer Science 2023-02-20 Atish Agarwala , Yann N. Dauphin

Deep learning has become a popular tool for medical image analysis, but the limited availability of training data remains a major challenge, particularly in the medical field where data acquisition can be costly and subject to privacy…

Image and Video Processing · Electrical Eng. & Systems 2024-06-11 Aghiles Kebaili , Jérôme Lapuyade-Lahorgue , Su Ruan

Classic zeroth-order optimization approaches typically optimize for a smoothed version of the original function, i.e., the expected objective under randomly perturbed model parameters. This can be interpreted as encouraging the loss values…

Machine Learning · Computer Science 2025-10-21 Xuchen Gong , Tian Li

The introduction of saliency map algorithms as an approach for assessing the interoperability of images has allowed for a deeper understanding of current black-box models with Artificial Intelligence. Their rise in popularity has led to…

Image and Video Processing · Electrical Eng. & Systems 2023-06-29 Evan Kellener , Ihina Nath , An Ngo , Thomas Nguyen , Joshua Schuman , Coen Adler , Arnav Kartikeya

Flat regions of the neural network loss landscape have long been hypothesized to correlate with better generalization properties. A closely related but distinct problem is training models that are robust to internal perturbations to their…

Machine Learning · Computer Science 2026-02-10 Philip Jacobson , Ben Feinberg , Suhas Kumar , Sapan Agarwal , T. Patrick Xiao , Christopher Bennett

Image normalization is a building block in medical image analysis. Conventional approaches are customarily utilized on a per-dataset basis. This strategy, however, prevents the current normalization algorithms from fully exploiting the…

Machine Learning · Computer Science 2020-10-06 Pierre-Luc Delisle , Benoit Anctil-Robitaille , Christian Desrosiers , Herve Lombaert

Deep learning has revolutionized neuroimage analysis by delivering unprecedented speed and accuracy. However, the narrow scope of many training datasets constrains model robustness and generalizability. This challenge is particularly acute…

Image and Video Processing · Electrical Eng. & Systems 2025-12-08 Malte Hoffmann

Recently, we have witnessed great progress in the field of medical imaging classification by adopting deep neural networks. However, the recent advanced models still require accessing sufficiently large and representative datasets for…

Computer Vision and Pattern Recognition · Computer Science 2020-10-30 Haoliang Li , YuFei Wang , Renjie Wan , Shiqi Wang , Tie-Qiang Li , Alex C. Kot

Recent advancements in foundation models, such as the Segment Anything Model (SAM), have shown strong performance in various vision tasks, particularly image segmentation, due to their impressive zero-shot segmentation capabilities.…

Computer Vision and Pattern Recognition · Computer Science 2025-05-12 Pengfei Gu , Haoteng Tang , Islam A. Ebeid , Jose A. Nunez , Fabian Vazquez , Diego Adame , Marcus Zhan , Huimin Li , Bin Fu , Danny Z. Chen

Normalization layers (e.g., Batch Normalization, Layer Normalization) were introduced to help with optimization difficulties in very deep nets, but they clearly also help generalization, even in not-so-deep nets. Motivated by the long-held…

Machine Learning · Computer Science 2023-01-18 Kaifeng Lyu , Zhiyuan Li , Sanjeev Arora

Data augmentation has proved extremely useful by increasing training data variance to alleviate overfitting and improve deep neural networks' generalization performance. In medical image analysis, a well-designed augmentation policy usually…

Computer Vision and Pattern Recognition · Computer Science 2021-03-31 Yunhe Gao , Zhiqiang Tang , Mu Zhou , Dimitris Metaxas

Neural networks trained by empirical risk minimization often suffer from overfitting, especially to specific samples or domains, which leads to poor generalization. Curriculum Learning (CL) addresses this issue by selecting training samples…

Computer Vision and Pattern Recognition · Computer Science 2025-08-27 Hiroaki Aizawa , Yoshikazu Hayashi

Despite the successes of deep neural networks on many challenging vision tasks, they often fail to generalize to new test domains that are not distributed identically to the training data. The domain adaptation becomes more challenging for…

Computer Vision and Pattern Recognition · Computer Science 2021-03-08 Devavrat Tomar , Manana Lortkipanidze , Guillaume Vray , Behzad Bozorgtabar , Jean-Philippe Thiran

Over the years, the paradigm of medical image analysis has shifted from manual expertise to automated systems, often using deep learning (DL) systems. The performance of deep learning algorithms is highly dependent on data quality.…

Image and Video Processing · Electrical Eng. & Systems 2022-10-04 Sidra Aleem , Teerath Kumar , Suzanne Little , Malika Bendechache , Rob Brennan , Kevin McGuinness

Data augmentation is a widely used and effective technique to improve the generalization performance of deep neural networks. Yet, despite often facing limited data availability when working with medical images, it is frequently…

Image and Video Processing · Electrical Eng. & Systems 2025-07-21 Adam Tupper , Christian Gagné

Developing a deep learning method for medical segmentation tasks heavily relies on a large amount of labeled data. However, the annotations require professional knowledge and are limited in number. Recently, semi-supervised learning has…

Image and Video Processing · Electrical Eng. & Systems 2023-12-05 Wanqin Ma , Huifeng Yao , Yiqun Lin , Jiarong Guo , Xiaomeng Li

The Segment Anything Model (SAM) is widely used for segmenting a diverse range of objects in natural images from simple user prompts like points or bounding boxes. However, SAM's performance decreases substantially when applied to…

Computer Vision and Pattern Recognition · Computer Science 2025-04-24 Tristan Piater , Björn Barz , Alexander Freytag