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When a blood vessel ruptures or gets inflamed, the human body responds by rapidly forming a clot to restrict the loss of blood. Platelets aggregation at the injury site of the blood vessel occurring via platelet-platelet adhesion, tethering…

Tissues and Organs · Quantitative Biology 2015-06-18 Ziheng Wu , Zhiliang Xu , Oleg Kim , Mark Alber

Microfluidic technology has emerged as a powerful tool for studying complex biological processes with enhanced precision and control. A microfluidic chip was designed to emulate human-like microvascular networks with precise control over…

Biological Physics · Physics 2025-02-18 Shobhit Das , Shilpi Pandey , Oliver Hayden

Realistic description of patient-specific mechanical properties of clotting dynamics presents a major challenge. Available patient-specific data falls short of robustly characterizing myriads of complex dynamic interactions that happen…

Molecular Networks · Quantitative Biology 2017-05-23 Jayavel Arumugam , Arun Srinivasa

Occlusive thrombosis in arteries causes heart attacks and strokes. The rapid growth of thrombus at elevated shear rates (~10,000 1/s) relies on shear-induced platelet aggregation (SIPA) thought to come about from the entanglement of von…

Biological Physics · Physics 2021-03-04 Zixiang L Liu , David N Ku , Cyrus K Aidun

Containment measures implemented by some countries to suppress the spread of COVID-19 have resulted in a slowdown of the epidemic characterized by time series of daily infections plateauing over extended periods of time. We prove that such…

Physics and Society · Physics 2020-11-17 Filippo Radicchi , Ginestra Bianconi

Modeling epidemic dynamics plays an important role in studying how diseases spread, predicting their future course, and designing strategies to control them. In this letter, we introduce a model of SIR (susceptible-infected-removed) type…

Populations and Evolution · Quantitative Biology 2013-12-17 Li Chen , Fakhteh Ghanbarnejad , Weiran Cai , Peter Grassberger

The last decade saw the advent of increasingly realistic epidemic models that leverage on the availability of highly detailed census and human mobility data. Data-driven models aim at a granularity down to the level of households or single…

Populations and Evolution · Quantitative Biology 2011-08-10 Nicola Perra , Duygu Balcan , Bruno Gonçalves , Alessandro Vespignani

In this paper we consider a model for the spread of a stochastic SIR (Susceptible $\to$ Infectious $\to$ Recovered) epidemic on a network of individuals described by a random intersection graph. Individuals belong to a random number of…

Probability · Mathematics 2014-04-29 Frank G. Ball , David J. Sirl , Pieter Trapman

Subclinical leaflet thrombosis (SLT) is a potentially serious complication of aortic valve replacement with a bioprosthetic valve in which blood clots form on the replacement valve. SLT is associated with increased risk of transient…

In the context of a pandemic like COVID-19, and until most people are vaccinated, proactive testing and interventions have been proved to be the only means to contain the disease spread. Recent academic work has offered significant evidence…

This paper proposes a general model for synchronized crowding behavior. An order parameter is introduced to quantify the level of synchronization which is shown a function of percentage of agents in reactive state. Further, synchronization…

General Finance · Quantitative Finance 2016-12-06 Jake J. Xia

Sepsis is a major public health concern due to its high morbidity, mortality, and cost. Its clinical outcome can be substantially improved through early detection and timely intervention. By leveraging publicly available datasets, machine…

Machine Learning · Computer Science 2026-02-04 Yin Jin , Tucker R. Stewart , Deyi Zhou , Chhavi Gupta , Arjita Nema , Scott C. Brakenridge , Grant E. O'Keefe , Juhua Hu

We propose a simple SIR model in order to investigate the impact of various confinement strategies on a most virulent epidemic. Our approach is motivated by the current COVID-19 pandemic. The main hypothesis is the existence of two…

Populations and Evolution · Quantitative Biology 2020-12-30 G. Nakamura , B. Grammaticos , M. Badoual

Using a probability of novel encounter derived from a physical model, we augment the SIR compartmental model for disease spread. Scenarios with the same initial trajectories and identical $R_0$ values can diverge greatly depending on the…

Populations and Evolution · Quantitative Biology 2020-06-15 Peter Cotton

In a collection of particles performing independent random walks on $\mathbb Z^d$ we study the spread of an infection with SIR dynamics. Susceptible particles become infected when they meet an infected particle. Infected particles heal and…

Probability · Mathematics 2022-09-14 Duncan Dauvergne , Allan Sly

Signal-based early detection of illnesses has been a key topic in research and hospital settings; it reduces technological costs and paves the way for quick and effective patient-care operations. Elementary machine learning and signal…

Other Quantitative Biology · Quantitative Biology 2020-11-04 Camille Dunning

In this work, the spread of a contagious disease on a society where the individuals may take precautions is modeled. The primary assumption is that the infected individuals transmit the infection to the susceptible members of the community…

Physics and Society · Physics 2021-03-16 Semra Gunduc

Red blood cells are known to form aggregates in the form of rouleaux. This aggregation process is believed to be reversible, but there is still no full understanding on the binding mechanism. There are at least two competing models, based…

Biological Physics · Physics 2015-06-17 C. Wagner , P. Steffen , S. Svetina

We study the susceptible-infective-recovered (SIR) epidemic on a random graph chosen uniformly subject to having given vertex degrees. In this model infective vertices infect each of their susceptible neighbours, and recover, at a constant…

Probability · Mathematics 2014-09-24 Svante Janson , Malwina Luczak , Peter Windridge

The susceptible-infected-recovered (SIR) model and its variants form the foundation of our understanding of the spread of diseases. Here, each agent can be in one of three states (susceptible, infected, or recovered), and transitions…

Disordered Systems and Neural Networks · Physics 2023-12-25 Claudia Merger , Jasper Albers , Carsten Honerkamp , Moritz Helias
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