A Novel Simplified Model for Blood Coagulation: A piecewise dynamical model for thrombin with robust predictive capabilities
Abstract
Realistic description of patient-specific mechanical properties of clotting dynamics presents a major challenge. Available patient-specific data falls short of robustly characterizing myriads of complex dynamic interactions that happen during clotting. We propose a simplified switching model for a key part of the coagulation cascade that describes dynamics of just four variables. The model correctly predicts prolonged activity of thrombin, an important enzyme in the clotting process, in certain plasma factor compositions. The activity sustains beyond the time which is conventionally considered to be the end of clotting. This observation along with the simplified model is hypothesized as a necessary step towards effectively studying patient-specific properties of clotting dynamics in realistic geometries.
Keywords
Cite
@article{arxiv.1705.07182,
title = {A Novel Simplified Model for Blood Coagulation: A piecewise dynamical model for thrombin with robust predictive capabilities},
author = {Jayavel Arumugam and Arun Srinivasa},
journal= {arXiv preprint arXiv:1705.07182},
year = {2017}
}
Comments
20 pages, 15 figues