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Scientific visualization pipelines encode domain-specific procedural knowledge with strict execution dependencies, making their construction sensitive to missing stages, incorrect operator usage, or improper ordering. Thus, generating…

Graphics · Computer Science 2026-03-30 Guanghui Zhao , Zhe Wang , Yu Dong , Guan Li , GuiHua Shan

Designing novel proteins that bind to small molecules is a long-standing challenge in computational biology, with applications in developing catalysts, biosensors, and more. Current computational methods rely on the assumption that the…

Biomolecules · Quantitative Biology 2024-09-19 Junqi Liu , Shaoning Li , Chence Shi , Zhi Yang , Jian Tang

Learning effective protein representations is critical in a variety of tasks in biology such as predicting protein functions. Recent sequence representation learning methods based on Protein Language Models (PLMs) excel in sequence-based…

Quantitative Methods · Quantitative Biology 2023-10-19 Zuobai Zhang , Chuanrui Wang , Minghao Xu , Vijil Chenthamarakshan , Aurélie Lozano , Payel Das , Jian Tang

Scalar features in time-dependent fluid flow are traditionally visualized using 3D representation, and their topology changes over time are often conveyed with abstract graphs. Using such techniques, however, the structural details of…

Leveraging hypergraph structures to model advanced processes has gained much attention over the last few years in many areas, ranging from protein-interaction in computational biology to image retrieval using machine learning. Hypergraph…

Human-Computer Interaction · Computer Science 2021-12-07 Maximilian T. Fischer , Alexander Frings , Daniel A. Keim , Daniel Seebacher

Protein design is a fundamental challenge in biotechnology, aiming to design novel sequences with specific functions within the vast space of possible proteins. Recent advances in deep generative models have enabled function-based protein…

Machine Learning · Computer Science 2025-10-15 Nuowei Liu , Jiahao Kuang , Yanting Liu , Tao Ji , Changzhi Sun , Man Lan , Yuanbin Wu

Dynamic graph visualization attracts researchers' concentration as it represents time-varying relationships between entities in multiple domains (e.g., social media analysis, academic cooperation analysis, team sports analysis). Integrating…

Human-Computer Interaction · Computer Science 2022-06-13 Baofeng Chang , Sujia Zhu , Qi Jiang , Wang Xia , Jingwei Tang , Lvhan Pan , Ronghua Liang , Guodao Sun

A geometric analysis of protein folding, which complements many of the models in the literature, is presented. We examine the process from unfolded strand to the point where the strand becomes self-interacting. A central question is how it…

Mathematical Physics · Physics 2008-09-13 Walter A. Simmons , Joel L. Weiner

Inferring the structural properties of a protein from its amino acid sequence is a challenging yet important problem in biology. Structures are not known for the vast majority of protein sequences, but structure is critical for…

Machine Learning · Computer Science 2019-10-17 Tristan Bepler , Bonnie Berger

Numerical simulations are commonly used to understand the parameter dependence of given spatio-temporal phenomena. Sampling a multi-dimensional parameter space and running the respective simulations leads to an ensemble of a large number of…

Human-Computer Interaction · Computer Science 2022-05-04 Marina Evers , Lars Linsen

Deep learning is catalyzing a scientific revolution fueled by big data, accessible toolkits, and powerful computational resources, impacting many fields including protein structural modeling. Protein structural modeling, such as predicting…

Biomolecules · Quantitative Biology 2020-07-17 Wenhao Gao , Sai Pooja Mahajan , Jeremias Sulam , Jeffrey J. Gray

Proteins are essential for almost all biological processes and derive their diverse functions from complex 3D structures, which are in turn determined by their amino acid sequences. In this paper, we exploit the rich biological inductive…

Visualization for machine learning (VIS4ML) research aims to help experts apply their prior knowledge to develop, understand, and improve the performance of machine learning models. In conceiving VIS4ML systems, researchers characterize the…

Human-Computer Interaction · Computer Science 2023-08-15 Hariharan Subramonyam , Jessica Hullman

Recent advances in protein function prediction exploit graph-based deep learning approaches to correlate the structural and topological features of proteins with their molecular functions. However, proteins in vivo are not static but…

Biomolecules · Quantitative Biology 2022-11-22 Yuan Chiang , Wei-Han Hui , Shu-Wei Chang

Visual analysis and reconstruction of pipeline inner walls remain challenging in industrial inspection scenarios. This paper presents a dedicated reconstruction system for pipeline inner walls via industrial endoscopes, which is built on…

Computer Vision and Pattern Recognition · Computer Science 2026-05-07 Rui Ma , Yifeng Wang , Ziteng Yang , Jing Guo , Naomi Imali Okanda , Xinghui Li

This paper presents CLIPXPlore, a new framework that leverages a vision-language model to guide the exploration of the 3D shape space. Many recent methods have been developed to encode 3D shapes into a learned latent shape space to enable…

Computer Vision and Pattern Recognition · Computer Science 2023-06-16 Jingyu Hu , Ka-Hei Hui , Zhengzhe liu , Hao Zhang , Chi-Wing Fu

A typical problem in Visual Analytics is that users are highly trained experts in their application domains, but have mostly no experience in using VA systems. Thus, users often have difficulties interpreting and working with visual…

Human-Computer Interaction · Computer Science 2023-08-21 Christina Stoiber , Davide Ceneda , Markus Wagner , Victor Schetinger , Theresia Gschwandtner , Marc Streit , Silvia Miksch , Wolfgang Aigner

Circular genome visualizations are essential for exploring structural variants and gene regulation. However, existing tools often require complex scripting and manual configuration, making the process time-consuming, error-prone, and…

Genomics · Quantitative Biology 2025-07-08 Chi Zhang , Yu Dong , Yang Wang , Yuetong Han , Guihua Shan , Bixia Tang

Graph representation learning is a fast-growing field where one of the main objectives is to generate meaningful representations of graphs in lower-dimensional spaces. The learned embeddings have been successfully applied to perform various…

Machine Learning · Computer Science 2021-12-21 Md. Khaledur Rahman , Ariful Azad

Folded proteins have a modular assembly. They are constructed from regular secondary structures like alpha-helices and beta-strands that are joined together by loops. Here we develop a visualization technique that is adapted to describe…

Biological Physics · Physics 2015-06-11 Martin Lundgren , Antti J. Niemi , Fan Sha
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