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The ability to dynamically extend a model to new data and classes is critical for multiple organ and tumor segmentation. However, due to privacy regulations, accessing previous data and annotations can be problematic in the medical domain.…

Image and Video Processing · Electrical Eng. & Systems 2023-07-24 Yixiao Zhang , Xinyi Li , Huimiao Chen , Alan Yuille , Yaoyao Liu , Zongwei Zhou

Causal inference across multiple data sources offers a promising avenue to enhance the generalizability and replicability of scientific findings. However, data integration methods for time-to-event outcomes, common in biomedical research,…

Methodology · Statistics 2025-05-16 Yi Liu , Alexander W. Levis , Ke Zhu , Shu Yang , Peter B. Gilbert , Larry Han

Technological advances in medical data collection, such as high-throughput genomic sequencing and digital high-resolution histopathology, have contributed to the rising requirement for multimodal biomedical modelling, specifically for…

Machine Learning · Computer Science 2024-10-29 Konstantin Hemker , Nikola Simidjievski , Mateja Jamnik

Accurate and interpretable survival analysis remains a core challenge in oncology. With growing multimodal data and the clinical need for transparent models to support validation and trust, this challenge increases in complexity. We propose…

Artificial Intelligence · Computer Science 2025-09-29 Mafalda Malafaia , Peter A. N. Bosman , Coen Rasch , Tanja Alderliesten

In the field of lung cancer research, particularly in the analysis of overall survival (OS), artificial intelligence (AI) serves crucial roles with specific aims. Given the prevalent issue of missing data in the medical domain, our primary…

Machine Learning · Computer Science 2026-03-13 Camillo Maria Caruso , Valerio Guarrasi , Sara Ramella , Paolo Soda

In the early stages of drug discovery, decisions regarding which experiments to pursue can be influenced by computational models. These decisions are critical due to the time-consuming and expensive nature of the experiments. Therefore, it…

Machine Learning · Computer Science 2024-09-09 Emma Svensson , Hannah Rosa Friesacher , Susanne Winiwarter , Lewis Mervin , Adam Arany , Ola Engkvist

In real-world applications, as data availability increases, obtaining labeled data for machine learning (ML) projects remains challenging due to the high costs and intensive efforts required for data annotation. Many ML projects,…

Machine Learning · Computer Science 2024-12-24 Ismail Hakki Karaman , Gulser Koksal , Levent Eriskin , Salih Salihoglu

Conventional approaches to statistical inference preclude structures that facilitate incorporation of supplemental information acquired from similar circumstances. For example, the analysis of data obtained using perfusion computed…

Applications · Statistics 2015-11-18 Thomas A. Murray , Brian P. Hobbs , Bradley P. Carlin

As in many fields of medical research, survival analysis has witnessed a growing interest in the application of deep learning techniques to model complex, high-dimensional, heterogeneous, incomplete, and censored medical data. Current…

Machine Learning · Computer Science 2023-12-25 Patricia A. Apellániz , Juan Parras , Santiago Zazo

Learning multimodal representations from medical images and other data sources can provide richer information for decision-making. While various multimodal models have been developed for this, they overlook learning features that are both…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Boyu Chen , Weiye Bao , Junjie Liu , Michael Shen , Bo Peng , Paul Taylor , Zhu Li , Mengyue Yang

Pseudo-Labeling is a simple and effective approach to semi-supervised learning. It requires criteria that guide the selection of pseudo-labeled data. The latter have been shown to crucially affect pseudo-labeling's generalization…

Machine Learning · Computer Science 2023-09-27 Julian Rodemann

Computational capability often falls short when confronted with massive data, posing a common challenge in establishing a statistical model or statistical inference method dealing with big data. While subsampling techniques have been…

Methodology · Statistics 2024-10-31 Yixiao Ruan , Zan Li , Zhaohui Li , Dennis K. J. Lin , Qingpei Hu , Dan Yu

Liver tumour ablation presents a significant clinical challenge: whilst tumours are clearly visible on pre-operative MRI, they are often effectively invisible on intra-operative CT due to minimal contrast between pathological and healthy…

Image and Video Processing · Electrical Eng. & Systems 2026-02-24 Budhaditya Mukhopadhyay , Chirag Mandal , Pavan Tummala , Naghmeh Mahmoodian , Andreas Nürnberger , Soumick Chatterjee

This paper develops a unified identification framework for counterfactual analysis in incomplete models characterized by support and moment restrictions. I demonstrate that identifying structural parameters and conducting counterfactual…

Econometrics · Economics 2026-03-10 Lixiong Li

Morphological attributes from histopathological images and molecular profiles from genomic data are important information to drive diagnosis, prognosis, and therapy of cancers. By integrating these heterogeneous but complementary data, many…

Machine Learning · Computer Science 2022-02-28 Kaiwen Tan , Weixian Huang , Xiaofeng Liu , Jinlong Hu , Shoubin Dong

Multi-label learning predicts a subset of labels from a given label set for an unseen instance while considering label correlations. A known challenge with multi-label classification is the long-tailed distribution of labels. Many studies…

Machine Learning · Computer Science 2021-12-06 Vithya Yogarajan , Bernhard Pfahringer , Tony Smith , Jacob Montiel

Training a neural network with a large labeled dataset is still a dominant paradigm in computational histopathology. However, obtaining such exhaustive manual annotations is often expensive, laborious, and prone to inter and Intra-observer…

Computer Vision and Pattern Recognition · Computer Science 2021-11-03 Chetan L. Srinidhi , Seung Wook Kim , Fu-Der Chen , Anne L. Martel

This paper challenges the cross-domain semantic segmentation task, aiming to improve the segmentation accuracy on the unlabeled target domain without incurring additional annotation. Using the pseudo-label-based unsupervised domain…

Computer Vision and Pattern Recognition · Computer Science 2021-12-02 Kai Zhang , Yifan Sun , Rui Wang , Haichang Li , Xiaohui Hu

Applications of machine learning in healthcare often require working with time-to-event prediction tasks including prognostication of an adverse event, re-hospitalization or death. Such outcomes are typically subject to censoring due to…

Machine Learning · Computer Science 2022-08-04 Chirag Nagpal , Willa Potosnak , Artur Dubrawski

Multimodal survival analysis aims to combine heterogeneous data sources (e.g., clinical, imaging, text, genomics) to improve the prediction quality of survival outcomes. However, this task is particularly challenging due to high…

Machine Learning · Computer Science 2024-12-03 Ling Huang , Yucheng Xing , Qika Lin , Su Ruan , Mengling Feng