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Gene expression datasets consist of thousand of genes with relatively small samplesizes (i.e. are large-$p$-small-$n$). Moreover, dependencies of various orders co-exist in the datasets. In the Undirected probabilistic Graphical Model (UGM)…

Molecular Networks · Quantitative Biology 2022-12-21 Catharina Elisabeth Graafland , José Manuel Gutiérrez

There have been several attempts to develop Feature Selection (FS) algorithms capable of identifying features that are relevant in a dataset. Although in certain applications the FS algorithms can be seen to be successful, they have similar…

Machine Learning · Computer Science 2025-03-18 Andrew Starkey , Uduak Idio Akpan , Omaimah AL Hosni , Yaseen Pullissery

Motivated by high-throughput single-cell cytometry data with applications to vaccine development and immunological research, we consider statistical clustering in large-scale data that contain multiple rare clusters. We propose a new…

Methodology · Statistics 2016-06-30 Lin Lin , Jia Li

Object re-identification method is made up of backbone network, feature aggregation, and loss function. However, most backbone networks lack a special mechanism to handle rich scale variations and mine discriminative feature…

Computer Vision and Pattern Recognition · Computer Science 2022-11-11 Fei Shen , Mengwan Wei , Junchi Ren

In this paper, we present novel variations of an earlier approach called homogeneous clustering algorithm for reducing dataset size. The intuition behind the approaches proposed in this paper is to partition the dataset into homogeneous…

Machine Learning · Computer Science 2022-08-30 Shril Mody , Janvi Thakkar , Devvrat Joshi , Siddharth Soni , Rohan Patil , Nipun Batra

We consider the analysis of high dimensional data given in the form of a matrix with columns consisting of observations and rows consisting of features. Often the data is such that the observations do not reside on a regular grid, and the…

Machine Learning · Statistics 2017-08-22 Gal Mishne , Ronen Talmon , Israel Cohen , Ronald R. Coifman , Yuval Kluger

Clustering genotypes based upon their phenotypic characteristics is used to obtain diverse sets of parents that are useful in their breeding programs. The Hierarchical Clustering (HC) algorithm is the current standard in clustering of…

Machine Learning · Computer Science 2020-09-22 Aditya A. Shastri , Kapil Ahuja , Milind B. Ratnaparkhe , Yann Busnel

Spectral clustering is a powerful technique for clustering high-dimensional data, utilizing graph-based representations to detect complex, non-linear structures and non-convex clusters. The construction of a similarity graph is essential…

Machine Learning · Computer Science 2025-01-27 Kamal Berahmand , Farid Saberi-Movahed , Razieh Sheikhpour , Yuefeng Li , Mahdi Jalili

This paper focuses on density-based clustering, particularly the Density Peak (DP) algorithm and the one based on density-connectivity DBSCAN; and proposes a new method which takes advantage of the individual strengths of these two methods…

Machine Learning · Computer Science 2024-01-30 Ye Zhu , Kai Ming Ting , Yuan Jin , Maia Angelova

We propose a novel method, scTree, for single-cell Tree Variational Autoencoders, extending a hierarchical clustering approach to single-cell RNA sequencing data. scTree corrects for batch effects while simultaneously learning a…

Machine Learning · Computer Science 2024-07-11 Moritz Vandenhirtz , Florian Barkmann , Laura Manduchi , Julia E. Vogt , Valentina Boeva

Interpretability is a key issue when applying deep learning models to longitudinal brain MRIs. One way to address this issue is by visualizing the high-dimensional latent spaces generated by deep learning via self-organizing maps (SOM). SOM…

Computer Vision and Pattern Recognition · Computer Science 2023-10-03 Jiahong Ouyang , Qingyu Zhao , Ehsan Adeli , Wei Peng , Greg Zaharchuk , Kilian M. Pohl

Hierarchical clustering is a fundamental task often used to discover meaningful structures in data, such as phylogenetic trees, taxonomies of concepts, subtypes of cancer, and cascades of particle decays in particle physics. Typically…

Data Structures and Algorithms · Computer Science 2020-10-23 Craig S. Greenberg , Sebastian Macaluso , Nicholas Monath , Ji-Ah Lee , Patrick Flaherty , Kyle Cranmer , Andrew McGregor , Andrew McCallum

Classification in the dissimilarity space has become a very active research area since it provides a possibility to learn from data given in the form of pairwise non-metric dissimilarities, which otherwise would be difficult to cope with.…

We consider joint estimation of multiple graphical models arising from heterogeneous and high-dimensional observations. Unlike most previous approaches which assume that the cluster structure is given in advance, an appealing feature of our…

Machine Learning · Statistics 2018-01-16 Botao Hao , Will Wei Sun , Yufeng Liu , Guang Cheng

Glioblastoma is a highly aggressive form of brain cancer characterized by rapid progression and poor prognosis. Despite advances in treatment, the underlying genetic mechanisms driving this aggressiveness remain poorly understood. In this…

Quantitative Methods · Quantitative Biology 2025-05-20 Ahmad Berjaoui , Louis Roussel , Eduardo Hugo Sanchez , Elizabeth Cohen-Jonathan Moyal

Unsupervised semantic segmentation aims to discover groupings within and across images that capture object and view-invariance of a category without external supervision. Grouping naturally has levels of granularity, creating ambiguity in…

Computer Vision and Pattern Recognition · Computer Science 2022-04-26 Tsung-Wei Ke , Jyh-Jing Hwang , Yunhui Guo , Xudong Wang , Stella X. Yu

Finding a set of nested partitions of a dataset is useful to uncover relevant structure at different scales, and is often dealt with a data-dependent methodology. In this paper, we introduce a general two-step methodology for model-based…

Computation · Statistics 2021-04-22 Etienne Côme , Nicolas Jouvin , Pierre Latouche , Charles Bouveyron

The human visual perception system demonstrates exceptional capabilities in learning without explicit supervision and understanding the part-to-whole composition of objects. Drawing inspiration from these two abilities, we propose…

Computer Vision and Pattern Recognition · Computer Science 2024-02-06 Shengcao Cao , Dhiraj Joshi , Liang-Yan Gui , Yu-Xiong Wang

Over the last decade, a large variety of clustering algorithms have been developed to detect coregulatory relationships among genes from microarray gene expression data. Model based clustering approaches have emerged as statistically well…

Quantitative Methods · Quantitative Biology 2008-01-15 Anagha Joshi , Yves Van de Peer , Tom Michoel

Semantic segmentation of electron microscopy (EM) images of biological samples remains a challenge in the life sciences. EM data captures details of biological structures, sometimes with such complexity that even human observers can find it…

Computer Vision and Pattern Recognition · Computer Science 2025-11-03 Sheida Rahnamai Kordasiabi , Damian Dalle Nogare , Florian Jug
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